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Picture of a river in the Blue Mountain area, Jamaica.
Research Interests
Natural product isolation for drug discovery especially from endemic plant species and microorganisms aided by bioassay-guided fractionation and dereplication procedures.
Structure elucidation of novel compounds using NMR, X-Ray, LCMS, and other technologies.
Biocatalysis of xenobiotics by microorganisms (bacteria and fungi) for enzyme and biochemical mechanism discovery.
Genetic and metabolic engineering of novel enzymes and organisms for the overproduction of proteins or metabolites using advanced biotechnology techniques.
Bacterial identification and taxonomy as a means of discovering new taxa and uncovering their potential.
Selected Publications
A. Collins Fairclough, C. Spröer, J. Swiderski, B. Bunk, and A. S. Lamm, Complete Genome Sequence of Nocardia iowensis DSM 45197T (= NRRL 5646T). Microbiology Resource Announcements, 2023, 12, Issue 1, e00581-222023. https://doi.org/10.1128/mra.00581-22.
J. Watson, D. Picking, A. S. Lamm, R. Delgoda. CYP450 activity inhibition by Guazuma ulmifolia and major phytochemical constituent, procyanidin β2 in vitro: assessing the potential for drug interactions. Planta Medica, 2019, 85, 1564.
A. S. Lamm, O. K. Brown and D. Gordon Smith. Antimicrobial Assay and Phytochemical Analysis of Verbesina karsticola Proctor. Jamaica Journal of Science and Technology, 2017, 27, 27.
A. S. Lamm. Using the Canadian ELAP Fellowship to expand and foster growth: My experience on Prince Edward Island. Jamaica Journal of Science and Technology, 2017, 27, 34.
J. Murray, D. Picking, A. Lamm, J. McKenzie, S. Hartley, C. Watson, L. Williams, H. Lowe, R. Delgoda. Significant inhibitory impact of dibenzyl trisulfide and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes in vitro: An assessment of the potential for medicinal plant-drug interactions. Fitoterapia 2016, 111, 138–146.
H. I. C. Lowe, D. Daley, C. Watson, S. Powell, K. N. N. Ayeah, N. J. Toyang, J. Bryant, and A. S. Lamm. Anticancer activity of three Jamaican macroalgae against prostate, pancreatic and skin cancers. European Journal of Medicinal Plants. 2016, 13, 1-5.
A. S. Lamm and P. B. Reese. Phytochemical investigation of Jamaican Capparis ferruginea. Journal of Arts, Science, and Technology. 2015, 8, 19-25.
A. S. Lamm, O. K. Brown and D. Gordon Smith. Endemic Plants in the Cockpit Country: Jamaica’s Treasure, Jamaica Journal of Science and Technology, 2014, 25, 14.
A. S. Lamm. Analysis and preservation of endemic plants in the Cockpit Country region of Jamaica. Planta Medica. 2012, 78, 1245.
S. Das, A. S. Lamm and J. P. N. Rosazza. Microbial Transformation of (+)-catechin and (-)-epicatechin: novel B-ring fission lactones. Organic Process Research and Development. 2011, 15, 231–235.
A. S. Lamm, A. Khare, P. Conville, P. C. K. Lau, H. Bergeron and J. P. N. Rosazza. Nocardia iowensis sp. nov.: An organism rich in biocatalytically important enzymes and nitric oxide synthase. International Journal of Systematic and Evolutionary Microbiology. 2009, 59, 2408-2414.
A. S. Lamm, A. R. M. Chen, W. F. Reynolds and P. B. Reese. Fungal hydroxylation of (-)-Santonin. Journal of Molecular Catalysis B: Enzymatic. 2009, 59, 292-296.
R. Seshadri, A. S. Lamm, A. Khare and J. P. N. Rosazza. Oxidation of Isoeugenol by Nocardia iowensis. Enzyme and Microbial Technology. 2008, 43, 486-494.
P. Venkitasubramanian, L. Daniels, S. Das, A. S. Lamm and J. P. N. Rosazza. Aldehyde Oxidoreductase as a biocatalyst: Reductions of vanillic acid. Enzyme and Microbial Technology. 2008, 42, 130-137.
A. S. Lamm, A. R. M. Chen, W. F. Reynolds and P. B. Reese. Steroid hydroxylation by Mucor plumbeus, Whetzelinia sclerotiorum, and Phanerochaete chrysosporium. Steroids. 2007, 72, 713-722.
A. S. Lamm, W. F. Reynolds and P. B. Reese. Bioconversion of Stemodia maritima diterpenes and derivatives by Cunninghamella echinulata var. elegans and Phanerochaete chrysosporium. Phytochemistry. 2006, 67, 1088-1093.
A. R. M. Chen, P. L. D. Ruddock, A. S. Lamm, W. F. Reynolds and P. B. Reese. Stemodane and stemarane diterpenoid hydroxylation by Mucor plumbeus and Whetzelinia sclerotiorum. Phytochemistry. 2005, 66, 1898-1902.
Book Chapters:
A. S. Lamm, P. Venkitasubramanian and J. P. N. Rosazza. Carboxylic Acid Reductase. In Science of Synthesis. Biocatalysis in Organic Synthesis 2. Thieme, Stuttgart. ISBN: 978-3-13-174161-5 (Softcover, 636 pages, 2015)
A. S. Lamm, A. Khare and J. P. N. Rosazza. Reduction of Carboxylic Acids by Carboxylic Acid Reductase (Car) heterologously expressed in E. coli. In, Practical Methods in Biocatalysis and Biotransformation. VCH-Wiley. ISBN: 978-0-470-51927-1 (Hardcover, 432 pages, 2010).
A. Khare, A. S. Lamm and J. P. N. Rosazza. Biotransformations of naphthalene to 4-hydroxy-1-tetralone by Streptomyces griseus NRRL 8090. In, Practical Methods in Biocatalysis and Biotransformation. VCH-Wiley. ISBN: 978-0-470-51927-1 (Hardcover, 432 pages, 2010)
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