Role of Membrane Proteins in Health and Disease
Our laboratory focuses on understanding the structure-function of membrane bound enzymes in their native-like lipid bilayer environment of Nanodiscs.
Research in our laboratory is highly interdisciplinary and collaborative. We have two primary research directions in our laboratory:
(1) Our primary research focus is elucidating the biochemical mechanism of eicosanoid synthesizing epoxygenases involved in converting omega-3 and omega-6 fatty acids into signaling molecules (eicosanoids). These molecules have been implicated in inflammation, cancer and cardiovascular diseases.
(2) We are also developing new biochemical and biophysical methodologies to identify osteosarcoma biomarkers in human, canine (pet dogs) and rats (collaboration Prof. Timothy Fan).
We also have collaboration with industry focusing on redesigning diterpinoid cytochrome P450s for natural product biosynthesis in simple biological systems.
All the above projects are empowered by the use of biochemical and biophysical techniques, basic bioengineering principles and Nanodiscs methodology.
We are a cohesive team of four graduate students and three undergraduates.
Our PI, Dr. Das obtained her Ph.D at Princeton University with Prof. Michael Hecht and post-doctoral training with Prof. Stephen G. Sligar at the University of Illinois Urbana Champaign. As a team we have published several papers in high impact journals that use an array of biochemical, spectroscopic, molecular biology and physical methodologies to study membrane-bound proteins that play key role in health and disease.
We acknowledge the funding from UIUC ICR funds, Research Board, American Heart Association and our industrial collaborators.
GROUP MEETING TIME
EVERY FRIDAY AT 3.30 PM at Veterinary Medicine Basic Sciences Building. Join us!!