Lipid Metabolism by Cytochrome P450 epoxygenases

Three pathways of eicosanoid synthesis.

(Modified from Dr. Guodong Zhang’s laboratory website)

Dietary consumption of ω-3 and ω-6 fatty acids changes the overall physiology in animals and humans. One of the pathways to change the overall physiology is the conversion of ω-3 and ω-6 fatty acids into epoxide derivatives via the enzymes in the cytochrome P450 epoxygenase (EPOX) pathway. Most of these epoxides are anti-inflammatory and vasodilatory in nature. The prime research direction in our laboratory is to elucidate the biochemical mechanism of the enzymes in the EPOX pathway (Work is funded by NIH R01 from National Institute of General Medical Sciences (NIGMS) and American Heart Association grant.

Another important research direction in the laboratory is the study of endocannabinoid metabolism by EPOX enzymes leading to the discovery of novel endocannabinoid epoxides that are anti-inflammatory and vasodilatory. (Work is funded by NIH R01 grant NIGMS and NIH R03 grant from NIDA (National Institute of Drug Abuse)).

Recent research directions in the laboratory is to study the metabolism of phytocannabinoids by cytochrome P450s to give rise to novel oxy-cannabinoids with altered and novel pharmacological properties. (Work is funded by NIH R21 grant from NIDA, NIH R21 grant from NCCIH)


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