Das Lab News


Das Laboratory 2021

Dr. Roy, Prof. Das, Kendall, Ghaith, Angel, Justin

Das lab is committed to fostering a supportive research environment that prioritizes the well-being and professional development of everyone who works in the laboratory. WE PLEDGE!!

Prof. Das gives invited talk to the Department of Chemistry at University of New South Wales in Sydney, Australia

Thanks to Prof. Kris Kilian for the invitation!!

Kris is a long-term friend and collaborator of Das Lab.

Das Lab has invited Prof. Heather Bradshaw from Indiana University Bloomington to give a seminar on the following topic.

"Regulation of endocannabinoids and related lipids by THC and CBD: effects of sex, enzymes, and development?"

Date Sep 28, 2021 Time 4:00 pm

Location https://illinois.zoom.us/j/83566081431?pwd=VllERlduN0hrUUYzQ1p0YTk2U2xKZz09

Das Group was awarded the El Sohly Award 2022 by the American Chemical Society for molecular research on cannabinoid metabolism by cytochrome P450s.

Das Lab Welcomes Kendall Blackenberg and Sathvik Pai as project students

Kendall is a sophomore in Chemical Engineering

Sathvik is a sophomore in Material Engineering

CYP2D6 paper on phytocannabinoid metabolism and inhibition is accepted in ACS Biochemistry.

It is a collaborative effort with Emad Tajkhorshid's group led by Archit Vasan. Congratulations to Dr. Hannah Huff, the first author!!.

Deepest thanks to Dr. Pritam Roy who single handedly managed the review of this paper which made the paper stronger!!

Crystal Lake Park Canoeing

Laboratory generates trash. In this brilliant video (starring Das Lab researchers), Dr. Pritam Roy shows that ........ See for yourself.

First Summer Laboratory Get Together 2021 ( We recruit them young)

(From Left) Daphne, Dr. Deo, Dr. Roy, AJ, Justin, Mark, Beckah, Marko

Greetings from a former student: Ms. Susan Zelasko

Susan Zelasko always wanted her work to help others. It wasn’t until college though, when she realized that research could be another powerful avenue to help others. During Zelasko’s undergrad at UIUC, she worked with Dr. Aditi Das. “She really opened up my eyes to how research can be a great tool for addressing some of the big issues in medicine,” Zelasko said. Instead of deciding between medicine and research, Zelasko is pursuing both in the joint MD/PhD Program at UW-Madison.

Prof. Das will serve as a permanent study section member in Biochemistry and Biophysics of Membranes Study Section – BBM starting September 2021. This study section reviews research applications concerned with all biochemical and biophysical aspects of membrane structure and function, and with their constituent protein and lipid components. Emphasis is on the molecular details of processes that occur on or within membranes. Areas include use of biochemical and biophysical techniques to understand the structure and function of membranes and membrane-proteins.​

Quotation from NIH about being appointed as permanent study section “Membership on a study section represents a major commitment of professional time and energy, as well as a unique opportunity to contribute to the national biomedical research effort.”

Das Lab welcomes Ms. Kendall Blankenburg as a sophomore in Fall 2021. She is an undergraduate in the Chemical and Biomolecular Engineering Program at UIUC. She is a member of the Cancer Scholars Program with the CCIL, and she is interested in molecular pharmacology of omega-3 fatty acids and cannabinoids.

Minor Cannabinoid Research Group: David Dennis (Sarlah group), Mark, Pritam and Daphne (Das group). Looking forward to publishing papers together on minor cannabinoids.

Das Laboratory welcomes Mr. Angel Lopez as a Research Specialist to work on the Minor Cannabinoid in Cancer project.

Prof. Das gave an invited talk to Department of Chemical Biology and Pharmacology at Emory University.

Special Thanks to Prof. Edward Morgan (fellow P450 researcher) for the kind invitation.

Das Laboratory welcomes Ms. Yi-Chien (Tiffany) Tang as a graduate student from Neuroscience Program. Tiffany has a B.S. in Biochemistry from UCLA and has deep interest in Lipid Biochemistry.

Prof. Das gave an invited talk to Department of Chemistry and Biochemistry at Purdue University. Prof. Das was excited to meet several membrane protein enthusiasts.

Thanks to Prof. Angeline Lyon for hosting her.


Congratulations to Daphne Anand!! She will joining MCB as a graduate student in Fall 2021.

Das Laboratory was recently awarded the American Society of Nutrition (ASN) ELR Stokstad Award. Dr. Das will receive the award at the ASN Scientific Sessions and Annual Meeting, 2021. The award is given for outstanding fundamental research in nutrition. It is supported by an endowment from the family of ELR Stokstad. Dr. Das will receive $2,500 and an engraved plaque at the National Meeting. Dr. Das wants to thank Division of Nutritional Sciences (DNS) for the nomination.

Das Lab Welcomes Mr. Hossein Omidi-Ardali as a new graduate student from DNS. Hossein has MS degree from Tehran University of Medical Sciences (TUMS) in Clinical Biochemistry. He graduated with top honors.

INVITED TALK:

Prof. Das gave an invited talk to the Department of Chemistry and Biochemistry at Georgia Tech.

Thanks to Prof. Amit Reddi and Prof. M.G. Finn for this kind invitation.

Prof. Emily Scott was invited by Das Lab to deliver a talk at the Department of Biochemistry on using structural biology to develop better drugs for CYP17A1.

Cytochrome P450 17A1 with the prostate cancer drug abiraterone (Zytiga®).

INVITED TALK:

Prof. Das is giving an invited talk to the Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences

Thanks to Prof. Jed Lampe for his kind invitation.

Congratulations to Justin Kim who passed his preliminary exam in DNS.

Justin Kim is awarded the Margin of Excellence Grants to study effect of endocannabinoids on T-cells

Margin of Excellence Grants

Lipid epoxides target pain and inflammatory pathways

When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much more powerful effects than the molecules from which they are derived, which also regulate pain and inflammation. Reported in the Nature Communications, the study opens a new avenue of research in the effort to find alternatives to potentially addictive opioid pain killers, researchers say.

Congratulations to William Arnold and Lauren Carnevale who lead the study!!

Special thanks to Dr. Zili Xie, Javier Baylon, Dr. Josephine Lauderdale, Prof. Emad Tajkhorshid and Prof. Hongzhen Hu for all the scientific support.

https://www.nature.com/articles/s41467-021-20946-6

Justin Kim has been awarded William C. Rose Endowed Award from DNS.

William C Rose was an American biochemist and nutritionist. He discovered the amino acid threonine, and his research determined the necessity for essential amino acids in diet and the minimum daily requirements of all amino acids for optimal growth.

Dr. Roy made a Das Lab Video

Prof. Das comments for an Alzoforum article on a new excellent article on the use of sEH inhibitors in Alzheimer disease

https://www.alzforum.org/news/research-news/epoxide-hydrolase-fat-new-target-alzheimers-therapy

Astrocytes Agitated, Becalmed. [Science Translational Medicine, 2020.]

Aayush Kaul joins Das Laboratory as a research specialist

Aayush Kaul from Das Laboratory receives high distinction in his Undergraduate Thesis Work. Since the lab started, every year undergraduate students have received highest or high distinction in their thesis. Congratulations to Dr. Hannah Huff who mentored him.

Das Lab welcomes Dr. Pritam Roy as a postdoc from IIT Kharagpur

Welcome Ms. Annie Hooper (GS, Chemistry, Sarlah lab) as a Visiting Researcher

Das Lab is featured in Cancer Center News with our collaborators and colleagues

INVITED TALK:

Prof. Das gives invited talk to University of Michigan, Scott, Lampe and Estrada laboratory groups on Endocannabinoid and phytocannabinoid metabolism by P450s

Thank you Prof. Emily Scott for the kind invitation

Justin Kim, fourth year graduate student in our laboratory is representing DNS in the College of ACES

Wonderful joint presentation of Das Lab and Steelman Lab

At ILSI - Nutrition

Das Lab welcomes Dr. Pritam Roy as a new postdoctoral associate. Dr. Roy obtained his Ph.D. from IIT Kharagpur an have used several spectroscopic tools to do research on Dityrosine (DT) and nitrotyrosine (NT) formation in various proteins. ,

Swapnil Shah Class of 2020 is recipient of several awards and honors.

Here are some of them.

Class of 2020 Senior Honorary 100 award. A 2-time recipient of the Outstanding Leadership Award on behalf of McKinley Health Center and the University.

May 2020

We published a review paper on the structure-function studies of CYP2J2 epoxygenase in Pharmacology & Therapeutics (impact factor 11).

We want to thank Dr. Zeldin for inviting us to write this review. Congratulations to Austin and William who put major effort in writing this paper. We also thank Justin and Hannah and former Das lab members for working hard on this paper. This review is very long and comprehensive.

May 2020

Swapnil Shah who is a talented undergraduate was awarded High Distinction for this thesis. He is keeping the tradition of Das Lab alive . Congratulations and we wish you all the best!!

May 22nd 2020: CCIL SEED funding of 250K to DAS LAB, FAN LAB & SARLAH LAB Elucidating the Role of Minor Cannabinoids on Immune Cell Activation Involved in Lung Cancer Metastatic Progression

31st MARCH 2020

CONGRATULATIONS TO DR. HANNAH HUFF

March 2020

The laboratory welcomes Ms. Daphne Shravanthi Anand as a research specialist to Das Lab!!

Daphne has MS in Biochemistry from Karnataka and many years of diverse research experience at NIMHANS (National Institute of Mental Health and Neuroscience)

Hannah Huff purified COX-1 enzyme from sheep seminal vesicles that was used by a recent study from Chan Lab that was published in Angew Chem. 2020

Dr. Darryl Meling and Aditi Das

Opening the graduation non-alcoholic champagne bottle

Mark, Darryl, Hannah and Aditi Das

Better Late Than Never

Hannah and Brad's Wedding Celebration

Playing Chess at Holiday Party 2020

Dr. Das was awarded Zoetis Research Excellence Award by the College of Veterinary Medicine

William Arnold Hooding Ceremony 2019

Jahnabi Roy Hooding Ceremony 2018

November 2019

Mark Eschbach joins as a Research Specialist Chemistry

Profs. Panigrahy, Das and Ann-Skulas at the Eicosanoid Research Foundation (ERF) Florida

2019 National Award

ERF awarded Prof. Das, Young Investigator Award (Biochemistry & Molecular Pharmacology)

Our book chapter was released at the meeting by Springer

Group Trip to Curtis Orchard

Anonymous Assignment to Characters

NIH R21 funding to DAS LAB & SARLAH LAB to systematically evaluate the interaction of minor cannabinoids with pain receptors.

Gut Brain Axis (GBA) Fellowship

Justin Kim from Das Lab has received GBA fellowship from DNS. Dr. Das is also a preceptor of the USDA GBA fellowship grant from USDA. Congrats to Justin and the Das lab!!

CONGRATULATIONS TO JUSTIN KIM FOR PASSING HIS QUALS AT FIRST SHOT WITH FLYING COLORS

Lunch at Destihl to celebrate Summer 2019

National Award 2019

Prof. Das was awarded Mary Swartz Rose Award from American Society of Nutrition for Outstanding work n Bioactive Dietary Compounds

Celebrating the end of Spring semester 2019

Prof. Das meet Prof. Makris at CANBIC 2019 after many years.

Prof. Das is promoted to Associate professor with tenure

Justin Kim wins the best speaker award at the VetMed Research Day 2019 for this talk on "Endocannabinoid dysregulation in Multiple Sclerosis"

Lots of Good News and Awards and Recognitions!!

Congratulations to Insup Hong and Demetri Maroutsos for receiving High Distinction for their thesis

Congratulations to Justin Kim and Asma Albakri for winning Division of Nutritional Sciences Margin of Excellence Award

Congratulations to Aayush Kaul and Diane Wei for winning MCB summer fellowship!!

Congratulations to Benjamin Ray for winning Oliver J. Bell Merit Scholarship!!

Congratulations to Benjamin Ray for winning 2019 Berkowitz Summer Fellow

Das Lab wins several awards at MCB ceremony

Cayman chemicals is selling 19,20-EDP-EA (DHEA-epoxides), the newly discovered endocannabinoid epoxides reported in PNAS 2017.

Congratulations to Hannah Huff for publishing her first author paper on the challenging system where she showed that macromolecular crowding accelerates the metabolism of drugs by membrane bound cytochrome P450s. The paper was published in Protein Science !!

Congratulations to Prof. Aditi Das ! She has been selected to receive the National 2019 Mary Swartz Rose Young Investigator Award from the American Society for Nutrition (ASN) and its Foundation. This award is given to an investigator for outstanding research on the safety and efficacy of bioactive compounds for human health.

MIB Agents Osteosarcoma Alliance

Mission: The Mission of M.I.B. Agents is to Make It Better for children with osteosarcoma, bone cancer. Finally, M.I.B. Agents is dedicated to increasing research for better treatments and outcomes for those with osteosarcoma.

Dr. Das gives a talk on the involvement of the cannabinoid system in Osteosarcoma.


Prof. Das has been invited to give a talk on endocannabinoids in Osteosarcoma. The MIB FACTOR OS conference is the beautiful Ritz Carlton Miami.

Prof. Das was elected to the editorial board of Frontiers in Pharmacology and Current Drug Metabolism

This year's first paper is published in Journal of Lipid Research. This is the first paper from the collaboration with Sinha Lab and Fan Lab to use bioinformatics tools to do global lipidomics analysis. Congratulations to Dr. Jahnabi Roy who led the effort.

Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

Jahnabi Roy, Payam Dibaeinia, Timothy M. Fan, Saurabh Sinha, and Aditi Das* J. Lipid Res. 2019 60 (2)

Happy New Year 2019 From Das Laboratory

Das Lab Welcomes TJ Oh from Biochemistry as a Ph.D. student

November 2018

William Arnold defends his thesis and becomes Dr. William Arnold. The first minority graduate student from the laboratory. Will has accepted a post-doctoral position in Prof. David Julius and Yifan Chen's laboratory at UCSF and will be working on lipid modulation of pain channels. Good luck Will!!

November 2018

The Cancer center of Illinois had their annual meeting. Dr. Das was invited to present her work on the anti-cancer properties of the endocannabinoid epoxides

October 2018

Congratulations to Das Lab, Josh Gulley Lab and Nu-Chu Liang for getting NIH R21 Grant from NIDA"Effect of co-use of Alcohol and Cannabis on Rat Behavior!!" Thanks Lauren Carnevale for generating the THC metabolites Data for this project!!

September 2018

September 12th 2018 - Congratulations to Das Lab and Steelman Lab for getting DNS 20/20 Vision Award from the Division of Nutritional Sciences!!

August 2018

Aug 31st 2018 - Congratulations to the Das and Steelman Lab for obtaining a High Risk- High reward grant from NMSS (NATIONAL MULTIPLE SCLEROSIS SOCIETY) to study the role of endocannabinoid epoxides in MS patients.

Aug 27th 2018

Das Lab welcomes MCB rotation student Dylan Blaha from Kranz Lab to study the cross-talk of cancer cells with T-Cell and role of lipid mediators in this cross-talk.

July 2018

July 30th 2018, Congratulations to Das Lab for obtaining Instrument Grant Supplement from NIGMS to buy a much needed new HPLC machine for the laboratory. Thanks Josephine for helping me to put together the supplement.

Supplements for Equipment Purchases for NIGMS Awardees, NOT-GM-18-022.

July 17th 2018, Congratulations to Dr. Jahnabi Roy for publishing her paper in J. Med. Chem. Her paper has received a lot of press and has been highlighted in almost 25 news outlet.


Highlighted in Illinois News Bureau

Highlighted in Eureka Alert

Highlighted in many other sources

July 15th 2018, Das Lab Welcomes Daniel Castro as a rotation student from MCB. Welcome Dan!! Dan has previous research experience in HPLC-MS based separation of various compounds.

May 2018

May 15th 2018, Das Lab receives USDA - Future Interdisciplinary Research Explorations (FIRE) grant along with Andrew Steelman to study lipidomics changes in myelin sheath during infection. Congrats to Justin!! He generated the preliminary data for the project.

April 2018

April 13th 2018 - Dr. Das gives an invited talk at the Gill Center at Indian Bloomington. She deeply thanks Prof. Heather Bradshaw for inviting her and being a wonderful host.

April 2018 - William Arnold gives a talk at the Biochemistry department annual award meeting. He won the Colin Wraight best paper award for his paper in Biochemistry.

April 2018 - Dr. Das and Will are featured at Beckman Institute News.

https://beckman.illinois.edu/news/2018/04/doxorubicin-and-cardiotoxicity

March 2018

March 2018- Dr. Das and William Arnold present their work at the Winter Eicosanoid Meeting at Washington DC.

February 2018

Feb 9th 2018- Das Lab welcome Ms. Asma'a Alkabri from the Division of Nutritional Sciences. She will work on the link between endocannabinoids and Diabetes.

Feb 1st 2018- Dr. Das went to MSFA study section at Dallas.

December 2017

December 14th 2017- William Arnold biochemistry paper has been featured in F1000 prime. Thanks to John Imig for recommendation.

December 7th 2017- Dr. Das has been invited to deliver a talk at Winter Eicosanoid Meeting in the role of endocannabinoid epoxides in cancer.

December 5th 2017- Dr. Das gave an invited talk at UIC medical school, Division of Endocrinology, Diabetes and Metabolism. Special Thanks to Prof. Brian Layden for hosting her.



Holiday Cheers from Das Lab - Made by Austin W.

November 2017

November 30th 2017 - William Arnold wins competitive Travel Award to attend Winter Eicosanoid Meeting at Baltimore!!

November 30th 2017 - William Arnold's DOX paper was accepted in Biochemistry. CONGRATULATIONS WILLIAM!!

November 13th 2017 - Dr. Das hosted Prof. John Imig, from Medical College of Wisconsin. He is one of the leading experts of the Epoxide-Hypertension field.

November 10th 2017 - Jahnabi Roy defends her thesis. CONGRATULATIONS Jahnabi!!!

The first woman Ph.D. of the lab. She with her favorite molecule 10,11-EDP-EA.

She is joining scientist position at U.S. ARMY INSTITUTE OF SURGICAL RESEARCH.

November 3rd 2017- Santanu Ghosh from MCB has started rotation in the laboratory. Santanu has done his training in Presidency College and IIT Bombay in Biotechnology. Welcome Santanu!!

November 1st 2017- Das Lab welcomes Mr. Austin Weigle as a new Ph.D. student in the lab. Austin is a chemistry graduate student (chemical-biology track). He is going to work on plant cannabinoids.

September 19th 2017- Das Lab is hosting Prof. Ken Mackie from Indiana University Bloomington to give a seminar at the Neuroscience Program. Prof. Mackie is a leader in the field of cannabinoid receptors.


Left: Das Lab Group with Prof. Ken Mackie(From Left) Insup, Will, Demetri, Jos, Jahnabi, Lauren, Brendan, Ken Mackie, Aditi, Austin, Hannah and Justin

September 2017

September 14th 2017- Congratulations to Jahnabi!! Das Lab collaborative work with Fan Lab was published in PLOS One. This study compared the proteome of canine and human osteosarcoma. The paper was a work of almost three years of dedicated effort.

September 1st 2017- Dr. Das gave invited talk at the 20th International Conference of Cytochrome P450 at Dusseldorf, Germany. She had the pleasure of meeting Prof. Omura.

http://20iccp450.hhu.de/

August 2017

August 24th 2017- Brendan Sullivan from MCB is starting his rotation in Das Lab. Brendan is from ASU and has a lot of research experience working on various projects ranging from immunology, nuclear proteins to biophysics. He is interested in the link of endocannabinoids to inflammation resolution. Welcome Brendan!!

Aug 15th 2017- Das Lab welcome Justin Kim as a new Ph.D. student from the Division of Nutritional Sciences. Welcome Justin!!

August 15th 2017- Jahnabi published her recent work in PLOS one. This is our first collaborative paper with Prof. Tim Fan's Lab on Osteosarcoma. Congrats Jahnabi!

July 2017

July 19th 2017- Our lab's research is featured in several news articles.

Highlighted in Forbes

Highlighted in Bioscience Technology

Highlighted in Nutrition Insight

Highlighted in New Medical Life Sciences

Highlighted in Eurekalert

Many other places

July 17th 2017 - Mr. Austin Weigle from Department of Chemistry is going to rotate in Das Lab. Austin is a plant biologist with a minor in chemistry with interest in natural product synthesis. He is interested to work on the cannabinoid and endocannabinoid project.

June 8th 2017 - Big News!!!

The lab published in PNAS (Direct Submission).

Congratulations to Dan McDougle who lead the effort from conception to execution. We also want to congratulate Josephine who handled all the reviews and developed the in house PRESTO-Tango assay for receptor activation. The was a team effort and we collaborated with Kilian Lab, Johnson Lab and Holinstat Lab. We also want to thank Ko Lab and Campbell Lab for sharing their expertise on DMT-Myograph. Thank you for all the help!!

May 2017

May 31st 2017- Dr. Das is giving oral presentation at 20th International Conference on Cytochrome P450: Biochemistry, Biophysics and Biotechnology. The Conference will be held 27-31 August 2017 at the Heinrich-Heine University Düsseldorf.

May 30th 2017- William Arnold from Dr. Aditi Das’s research group for receiving the 2nd Colin A. Wraight Memorial Award for an Outstanding Paper.

Arnold WR, Baylon JL, Tajkhorshid E, and Das A. (2016) Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. Biochemistry 55:6969-6980.

May 8th 2017- Das Lab gets second NIH Grant from National Institute on Drug Abuse (NIDA) to elucidate the pharmacology of novel endocannabinoid epoxides.

Special Thanks to Dan McDougle who initiated this project and to Josephine Watson and Jahnabi Ray for producing the preliminary data for this work.

May 1st 2017

Celebration of the following events at Allerton Park- NIH R01 grant, John's graduation and Highest Distinction, Jos prelim exam and Hannah's prelim exam


(From Left) Demetri, John, Will, Lauren, Aditi, Jose, Jahnabi, Hannah

April 2017

April 25th 2017- Dr. Das's MCB150 interview has been posted here.

https://drive.google.com/file/d/0B8OUK_omPD_-dllWVXBOajN5cFk/view

April 24th 2017

Ms. Josepine Watson passed her prelim exam in the Department of Biochemistry.

Congrats Jose!!

April 10th 2017 - Mr. Insup Hong and Demetri Maroutsos has been award MCB summer fellowship. Congrats!!

March 2017

March 21st 2017 - Mr. Justin Kim has been selected for the Nutritional Sciences Research Excellence Assistantship given to the top entering student in the program. Congrats Justin!!

March 20th 2017 - Das lab welcomes Mr. Justin Kim as a new Ph.D student to the lab from the Division of Nutritional Sciences. Justin has majored in Biology from UMass Amherst and has published two papers. He has lot of interest in Biochemical and Molecular Nutrition. Welcome Justin!!

March 13 2017 - Dr. Das is giving invited talk at Department of Pharmacology, NYU medical school. Her host is Prof. Austin Guo (cancelled due to NY blizzard)

March 14th 2017 - Dr. Das is giving invited talk at the Department of Biology, Yeshiva University. Her host is Prof. Josefa Steinhauer.

February 2017

Feb 27th 2017 - Ms. Hannah Huff passed her prelim exam in the Department of Chemistry. Congrats Hannah!! Welcome to the second phase of Ph.D.

Feb 2nd 2017- Das Lab welcomes Mr. Insup Hong as an undergraduate researcher