Omega-3 Fatty Acid Derived Anti-Inflammatory Lipid Metabolites

Three pathways of eicosanoid synthesis. 
(Modified from Dr. Guodong Zhang’s laboratory website)

Dietary consumption of ω-3 and ω-6 fatty acids changes the overall physiology in animals and humans. One of the pathways to change the overall physiology is the conversion of ω-3 and ω-6 fatty acids into epoxide derivatives via the enzymes in the epoxygenase (EPOX) pathway. Most of these epoxides are anti-inflammatory in nature. The biochemistry of epoxygenases with respect to their complex interactions with ω-3 and ω-6 fatty acids is largely unknown. The prime research direction in our laboratory is to elucidate the biochemical function of the enzymes in the EPOX pathway and to study the biological role of the novel  anti-inflammatory ω-3 and ω-6 fatty acid epoxides. Another important research direction is the discovery of novel ω-3 fatty acid epoxides that are anti-inflammatory in nature. 



• National Scientist Development Award, American Heart Association (2015)

• Editorial Board, ChemistrySelect 2016

• Lightening Talk Speaker - LIPID MAPS Meeting 2014, 2015 and 2016

• NIEHS Travel Award - Winter Eicosanoid Meeting 2014

• Moog Lecture Series, Hauptman-Woodward Medical Research Institute

• ACS Travel Award

• Outstanding researched award for postdoctoral research by NSF-NU-NSEC

• FMC Corporation Graduate Fellowship, Princeton

• Dean's List for Honorific Fellowship, Princeton

• Science and Engineering First Year Princeton Graduate Fellowship

• CSIR-JRF Fellowship, India


Aditi received her undergraduate degree in chemistry from St. Stephen College, Delhi, followed by masters at Indian Institute of Technology (I.I.T.) Kanpur. She received her Ph.D in Chemistry with Dr. Michael Hecht at Princeton University. She further did her postdoctoral research with Dr. Stephen Sligar at University of Illinois Urbana Champaign (UIUC). In 2012, Aditi started her own research group in the Department of Comparative Biosciences at UIUC. She is also an affiliate faculty in the Department of Biochemistry, Department of Bioengineering, Center for Biophysics and Quantitative Biology, Neuroscience Program, Division of Nutritional Sciences and Beckman Institute for Advanced Science and Technology. 


Subpages (1): Outreach