Publication

• The ABCF proteins in Escherichia coli individually cope with ‘hard-to-translate’ nascent peptide sequences
  *Yuhei Chadani, Shun Yamanouchi, Eri Uemura, Kohei Yamasaki, Tatsuya Niwa, Toma Ikeda, Miku Kurihara, Wataru Iwasaki, *Hideki Taguchi
  Nucleic Acids Research, gkae309 (2024)

プレスリリース

• Mechanistic dissection of premature translation termination induced by acidic residues-enriched nascent peptide
  *Yuhei Chadani, Takashi Kanamori, Tatsuya Niwa, Kazuya Ichihara, Keiichi I. Nakayama, Akinobu Matsumoto, *Hideki Taguchi
  Cell Reports 42(12) 113569-113569 (2023)

プレスリリース

• Nascent chain-mediated translation regulation in bacteria: translation arrest and intrinsic ribosome destabilization
  Shinobu Chiba, Keigo Fujiwara, Yuhei Chadani, Hideki Taguchi
  The Journal of Biochemistry 173(4) 227-236 (2023)

• A method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell.
  Ayako Yamakawa#, *Tatsuya Niwa#, *Yuhei Chadani#, Akinao Kobo, *Hideki Taguchi
  Nucleic Acids Research 51(5):e30 (2023)

• Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes.
  Yosuke Ito#, *Yuhei Chadani#, Tatsuya Niwa, Ayako Yamakawa, Kodai Machida, Hiroaki Imataka, *Hideki Taguchi
  Nature Communications 13(1) 7451-7451 (2022)

• Prophage excision switches the primary ribosome rescue pathway and rescue-associated gene regulations in Escherichia coli.
  Haruka Onodera, Tatsuya Niwa, *Hideki Taguchi, *Yuhei Chadani
  Molecular Microbiology 119(1) 44-58  (2022)

• Shotgun Proteomics Revealed Preferential Degradation of Misfolded In Vivo Obligate GroE Substrates by Lon Protease in Escherichia coli.
  Tatsuya Niwa, Yuhei Chadani, Hideki Taguchi
  Molecules (Basel, Switzerland) 27(12) (2022)

• Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation.
  *Yuhei Chadani, Nobuyuki Sugata, Tatsuya Niwa, Yosuke Ito, Shintaro Iwasaki, Hideki Taguchi*
  The EMBO Journal 40(23) e108299 (2021)

• Transcription-translation of the Escherichia coli genome within artificial cells. 

Tatsuki Deyama, Yukino Matsui, Yuhei Chadani, Yasuhiko Sekine, Nobuhide Doi, Kei Fujiwara

Chemical communications (Cambridge, England) 57(80) 10367-10370 (2021)

• Escherichia coli small heat shock protein IbpA is an aggregation-sensor that self-regulates its own expression at posttranscriptional levels.
  Tsukumi Miwa, Yuhei Chadani, Hideki Taguchi
  Molecular Microbiology 115(1) 142-156 (2020)

• Intrinsic Ribosome Destabilization Underlies Translation and Provides an Organism with a Strategy of Environmental Sensing.
  Yuhei Chadani, Tatsuya Niwa, Takashi Izumi, Nobuyuki Sugata, Asuteka Nagao, Tsutomu Suzuki, Shinobu Chiba, Koreaki Ito, Hideki Taguchi
  Molecular Cell 68(3) 528-539 (2017)

• Integrated in vivo and in vitro nascent chain profiling reveals widespread translational pausing.
  Yuhei Chadani, Tatsuya Niwa, Shinobu Chiba, Hideki Taguchi, Koreaki Ito
  Proceedings of the National Academy of Sciences of the United States of America 113(7) E829-38 (2016)

• ArfA recognizes the lack of mRNA in the mRNA channel after RF2 binding for ribosome rescue.
  Daisuke Kurita, Yuhei Chadani, Akira Muto, Tatsuhiko Abo, Hyouta Himeno
  Nucleic Acids Research 42(21) 13339-52 (2014)

• The fail-safe system to rescue the stalled ribosomes in Escherichia coli. 

Tatsuhiko Abo, Yuhei Chadani

Frontiers in microbiology 5 156-156 (2014)

• ArfA recruits release factor 2 to rescue stalled ribosomes by peptidyl-tRNA hydrolysis in Escherichia coli.
  Yuhei Chadani, Koreaki Ito, Kazuhiro Kutsukake, Tatsuhiko Abo
  Molecular Microbiology 86(1) 37-50 (2012)

• Escherichia coli YaeJ protein mediates a novel ribosome-rescue pathway distinct from SsrA- and ArfA-mediated pathways.
  Yuhei Chadani, Katsuhiko Ono, Kazuhiro Kutsukake, Tatsuhiko Abo
  Molecular Microbiology 80(3) 772-785 (2011)

• trans-translation-mediated tight regulation of the expression of the alternative ribosome-rescue factor ArfA in Escherichia coli. 

Yuhei Chadani, Emi Matsumoto, Hiroaki Aso, Takeo Wada, Kazuhiro Kutsukake, Shizuyo Sutou, Tatsuhiko Abo

Genes & Genetic Systems 86(3) 151-163 (2011) 

• Nascentome analysis uncovers futile protein synthesis in Escherichia coli.
  Koreaki Ito, Yuhei Chadani, Kenta Nakamori, Shinobu Chiba, Yoshinori Akiyama, Tatsuhiko Abo
  PloS One 6(12) e28413 (2011)

• Ribosome rescue by Escherichia coli ArfA (YhdL) in the absence of trans-translation system.
  Yuhei Chadani, Katsuhiko Ono, Shin-Ichiro Ozawa, Yuichiro Takahashi, Kazuyuki Takai, Hideaki Nanamiya, Yuzuru Tozawa, Kazuhiro Kutsukake, Tatsuhiko Abo
  Molecular Microbiology 78(4) 796-808 (2010) 

• 翻訳初期の合成失敗リスクは生物に普遍的でアミノ酸使用頻度に影響を及ぼす

実験医学 41, 1341-1344 (2023)

• 翻訳途上で機能するタンパク質

細胞 53, 13-16 (2021)

• 翻訳伸長ダイナミクスと新生鎖フォールディング

生物物理　59, 137-140 (2019)

• 終止コドンに依らず翻訳を途中終了させる酸性アミノ酸の連続配列

バイオサイエンスとインダストリー 76, 239-241 (2018)

• 翻訳途上の新生ポリペプチド鎖が引き起こすリボソームの不安定化とその生理的意義

実験医学 36, 1364-1367 (2018)

• タンパク質は合成のされ方にも個性〜緩急リズム〜がある

バイオサイエンスとインダストリー 74, 428-430 (2016)