RNA Biology Laboratory

Faculty of Pharmaceutical Sciences, Hokkaido University 


2024年 4月


2023年 12

M2の中山くんとB4の野村さんが参加した研究の成果がMolecular Cellに出版されました。




2022年 8月



卒業生の高橋くんの論文がGenes to Cellsに出版されました。


修士1年の田中豪くんが第27回小型魚類研究会にて、Excellent Presentation Awardを受賞しました。


修士2年の井ノ上俊太郎くんが第26回小型魚類研究会にて、Best Presentation Awardを受賞しました。

A huge number of non-protein-coding (noncoding) transcripts have recently been identified by a series of large-scale transcriptome studies, and "long noncoding RNA (lncRNA)" has been arbitrarily defined as transcripts longer than 200 nt lacking protein-coding capacity. The lncRNAs constitute at least one-third of the genes in the human genome and exhibit more tissue- and temporal-specific expression patterns compared with protein-coding genes. Interestingly, many lncRNAs are mammalian-specific and are exclusively expressed in the brain, and a large fraction of lncRNAs associate with chromatin-modifying complexes and regulate epigenetic gene expression. Aside from the transcriptional regulators, another group of lncRNAs is abundantly expressed and accumulates in the nucleus, forming distinct structures or "nuclear bodies" in the nucleus. We are especially interested in the function of abundant nuclear lncRNAs, such as Nuclear paraspeckle assembly transcript 1 (Neat1), Metastasis-associated lung adenocarcinoma transcript 1 (Malat1), and Gomafu (Gomafu means speckled pattern in Japanese), all of which are specific to higher vertebrate species.