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Julian A. Abrams, MD Harris H. Wang, PhD Michael Quante, MD, PhD
Contact-PI: Julian A. Abrams, MD, Co-PI: Harris H. Wang, PhD, Michael Quante, MD, PhD
Julian A. Abrams, MD
Associate Professor of Medicine and Epidemiology, CUIMC
Co-Director, Clinical Biospecimen and Research Core, Columbia University Digestive and Liver Disease Research Center
Director of Clinical Research, Division of Digestive and Liver Diseases
PROJECT NARRATIVE
Deaths from cancers arising from the gastro-esophageal junction represent a major public health burden, yet the factors that drive early changes in this region remain poorly understood. We aim to gain a clearer understanding of the effects of secondary bile acids produced by bacteria in the gut on stem cells in gastro-esophageal region. This knowledge can in turn be translated to future efforts to target the gut microbiome to prevent gastro- esophageal cancer.
Link to Publications
Sandra Ryeom, PhD
Silas Maniatis, PhD
Karol P. Nowicki-Osuch, PhD
Contact PI: Sandra Ryeom, PhD, Co-PI: Silas Maniatis, PhD, Karol P. Nowicki-Osuch, PhD
Sandra Ryeom, PhD
Associate Professor
Division of Surgical Sciences in Surgery, CUIMC
Associate Dean for Postdoctoral Affairs and New Master’s Degree ProgramsVagelos College of Physicians and Surgeons, CUIMC
PROJECT NARRATIVE
To address fundamental questions regarding the cell-of-origin of distinct classes of gastric cancer, we will integrate novel mouse models, organotypic cultures of human and mouse cells using state- of-the-art single cell profiling and spatial transcriptional analyses. We will also explore the related issue of disease development by defining key transcriptional mediators of the progression to gastric cancer and then perform experimental validation. Taken together, our studies will address and resolve longstanding debates over the origins of gastric cancer while also defining possible targets to prevent cancer initiation.
Link to Publications
Anil K. Rustgi, MD
Marcia Cruz-Correa, MD, PhD
James (Jim) M. Wells, PhD
Contact PI: Anil K. Rustgi, MD, Co-PI: Marcia Cruz-Correa, MD, PhD, James M. Wells, PhD
Anil K. Rustgi, MD
Herbert and Florence Irving Professor of Medicine, CUIMC
Associate Dean of Oncology, Vagelos College of Physicians and Surgeons
Chief, Cancer Services, New York Presbyterian Hospital/CUIMC
Herbert and Florence Irving Director of the Herbert Irving Comprehensive Cancer Center (HICCC)
PROJECT NARRATIVE
Gastric cancer is common globally. We seek to develop and characterize model systems (iPSCs, organoids) to reveal how gastric intestinal metaplasia and dysplasia, precursors to gastric cancer, form. In so doing, we will unravel new insights into potential applications for prevention, early detection, screening and surveillance.
Link to Publications
Timothy C. Wang, MD
Jianwen Que, MD, PhD
Contact PI: Timothy C. Wang, MD, Co-PI: Jianwen Que, MD, PhD
Timothy C. Wang, MD
Dorothy L. and Daniel H. Silberberg Professor of Medicine, CUIMC
Chief, Division of Digestive and Liver Diseases
Co-Director, Tumor Biology and Microenvironment Program, Herbert Irving Comprehensive Cancer Center
Director, GI/Pancreas Program in Development, Herbert Irving Comprehensive Cancer Center
PROJECT NARRATIVE
Although stem/progenitor cells at the gastroesophageal junction have been shown in preclinical models to contribute to Barrett’s esophagus, their precise characteristics and mechanisms involved in neoplastic progression remain undefined. This proposed study will not only provide the molecular profile of mouse and human Barrett’s stem/progenitor cells but also offer insights into the role of p53 mutation and tuft cells in Barrett’s metaplasia and progression. The knowledge gained will provide a framework for identifying new therapy for reducing the risk of Barrett’s progression towards malignancy.
Link to Publications
Frank D. McKeon, PhD
Jaffer Ajani, MD
Wa Xian, PhD
Contact-PI: Frank D. McKeon, PhD, Co-PI: Jaffer A. Ajani, MD, Wa Xian, PhD
Frank McKeon, PhD
Professor, Director of Somatic Stem Cell Center
CPRIT Established Investigator in Cancer Research, University of Houston
PROJECT NARRATIVE
The molecular features of esophageal adenocarcinoma and intestinal gastric cancer suggest they are a single disease from a common and unusual cell-of-origin. Therapeutics that target this common cell-of-origin could contribute to strategies for the elimination of these lethal cancers.
Link to Publications
Eunyoung Choi, PhD
James Goldenring, MD, PhD
Contact-PI: Eunyoung Choi, PhD, Co-PI: James Goldenring, MD, PhD
Eunyoung Choi, PhD
Associate Professor, Department of Surgery
Associate Professor of Cell and Developmental Biology
Vanderbilt University Medical Center
PROJECT NARRATIVE Gastric cancer develops within a carcinogenic cascade from pre-cancerous metaplasia to dysplasia and adenocarcinoma. While the pre-cancerous metaplasia is possibly reversible, a key cell population which is responsible for mucosal recovery or neoplastic progression is to be defined. In this study, we will define mechanisms that control the cell lineage conversion of reparative SPEM cells, which are a major cell component of dysplasia, towards incomplete IM and more cancerous cell lineages.
Link to Publications
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