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This NCI program (funded through RFA-CA-21-026/RFA-CA-21-027) is designed to examine and define the earliest biological changes in malignant transformation. It builds on recent molecular classifications of gastroesophageal cancers, understanding of their cancer genomics, and advances in stem cell research to decipher how these cancers initially evolve at the cellular level.
The initiative addresses the complex mechanisms and effectors that direct the proliferation and expansion of tumor-initiating and tumor-progenitor cells to originate gastroesophageal cancers. Additionally, the focus of the research projects is on gastric and gastroesophageal junction (GEJ) adenocarcinomas.
An important goal of the program is to assess the biological mechanisms underlying increased prevalence of gastric and GEJ cancers in certain ethnic, racial, and gender populations. Collectively, the program aims to tackle the evolution of deadly gastroesophageal cancers, generate a scientific platform that sustains this research field, and foster new and ongoing research collaborations in this area.
Please see our website for more details and updates from the NCI.
Columbia/HICCC
Columbia/HICCC
Coordinating Center
Coordinating Center
Our Mission
Our Mission
POGEC's mission is to extend recent findings regarding molecular classifications and genomics of gastroesophageal (GE) cancers, examine and define how these cancers initially evolve at the cellular level, and compare and contrast the contributions and underlying mechanisms of tumor-initiating cells to risk and progression.
Our Vision
Our Vision
The CCC aims to realize the full potential of the POGEC by providing the necessary leadership, infrastructure, and oversight to support and catalyze collaborative research on GE cancers to reduce the global impact of disease.
Our Goals
Our Goals
The overall goal of the CCC will be to employ a highly collaborative approach with the necessary level of structure and coordination to support current and future cutting-edge transdisciplinary research. In doing so, the CCC will:
provide the leadership and organizational structure to facilitate cross collaboration through trainings, meetings, and working groups.
develop standardization and harmonization of data elements (e.g., track the cell of origin correctly) across research projects, enable the resolution of technical challenges, share models and resources, and advance the use of cutting-edge technologies.
facilitate equitable and FAIR (employing principles of findability, accessibility, interoperability, and reusability) access to in vivo and in vitro models, provide real-time feedback on research objectives, and allow for assessment of rigor and reproducibility.
provide training and support for early-stage investigators to conduct pilot work and engage in transdisciplinary research to build the next generation of scientists.
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