我於2010年在國立陽明大學取得神經科學博士學位。在完成一年的兵役後，我成為了連實驗室的博士後研究員。在攻讀博士學位期間，我專注於酸敏感離子通道（ASICs）在海馬內神經元中的亞基表達和功能特性，結合了電生理記錄和單細胞RT-PCR。我們發現ASICs的亞基組成和功能特性在海馬內神經元中是細胞類型特定的。 最近，單細胞電壓成像引起了我的注意。我目前正在建立相關的設備和技能。單細胞電壓成像為我們提供了檢測亞細胞域膜電位變化的非凡機會，這在膜片夾記錄中難以訪問。我們相信電壓成像技術將有助於理解神經元中的信息處理。 

學歷

學士：中山醫學大學 

博士：國立陽明大學（Lien lab, 2007-2010 ） 

博士後：耶魯大學 

發表著作

酸偵測離子孔道在海馬迴內中間神經元的細胞特異性表現 (博士論文)

Cell Type-Specific Expression of Acid-Sensing Ion Channels in Hippocampal Interneurons (PhD thesis) [PDF]

Feng KL, Weng JY*, Chen CC, Abubaker MB, Lin HW, Charng CC, Lo CC, de Belle JS, Tully T, Lien CC, Chiang AS. Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila. iScience 2021 Nov 25;24(12):103506. doi: 10.1016/j.isci.2021.103506. eCollection 2021 Dec 17. *Co-First author. [PubMed]

Weng JY, Celis C, Zecevic D. Using holographic illumination to study synaptic signal integration at individual dendritic spines. Neural Imaging and Sensing 2019, 1086514 (1 March 2019); doi: 10.1117/12.2507284. 

Tanese D*, Weng JY*, Zampini V, De Sars V, Canepari M, Rozsa B, Emiliani V, Zecevic D. Imaging membrane potential changes from dendritic spines using computer-generated holography. Neurophotonics 2017 Jul;4(3):031211. doi: 10.1117/1.NPh.4.3.031211. Epub 2017 May 12. *Co-First author. [PubMed]

Chan CF*, Kuo TW*, Weng JY*, Lin YC*, Chen TY*, Cheng JK, Lien CC. Ba2+-and bupivacaine-sensitive background K+ conductances mediate rapid EPSP attenuation in oligodendrocyte precursor cells. J Physiol (London) 2013 Oct 1; 591(19): 4843-58. *Co-First author. [PDF] [PubMed]

Wu PY, Huang YY, Chen CC, Hsu TT, Lin YC, Weng JY, Chien TC, Cheng IH, Lien CC. (2012) Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J Neurosci 2013 Jan 30; 33 (5): 1828-32. [PDF] [PubMed]

Weng JY, Lin YC, Lien CC. Cell Type-Specific Expression of Acid-Sensing Ion Channels in Hippocampal Interneurons. J Neurosci 2010 May 12; 30 (19): 6548-58. [PDF] [Supplemental Data] [PubMed]

Chiang PH, Yeh WC, Lee CT, Weng JY, Huang YY, Lien CC. M1-Like Muscarinic Acetylcholine Receptors Regulate Fast-Spiking Interneuron Excitability in Rat Dentate Gyrus. Neuroscience 2010 Aug 11; 169 (1): 39-51. [PDF] [PubMed]

Weng JY, Hsu TT, Sun SH. Functional characterization of P2Y1 versus P2X4 receptors in RBA-2 astrocytes: elucidate the roles of ATP release and protein kinase C. J Cell Biochem 2008 May 15;104(2):554-67. [PDF] [PubMed]

Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y. Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes. J Neurosci 2008 Mar 26;28(13): 3277-90. [PDF] [PubMed]

Lin CC, Huang CC, Lin KH, Cheng KH, Yang DM, Tsai YS, Ong RY, Huang YN, Kao LS. Visualization of Rab3A dissociation during exocytosis: a study by total internal reflection microscopy. J Cell Physiol 2007 May 211(2):316-26. [PDF] [PubMed]

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