NCATS-NASA State-of-the-Science Meeting:
3D Tissues and Microphysiological Systems
Meeting Location: NASA Headquarters, Washington, D.C.
Meeting Date: December 4, 2018
NCATS-NASA State-of-the-Science Meeting: 3D Tissues and Microphysiological Systems
The development of 3D tissues and microphysiological systems (MPS) have been advancing for the past decade at an overwhelming rate providing more advanced tissues and miniaturized organ constructs to better evaluate drug toxicities and mechanisms of cellular and tissue damage in vitro. 3D tissues and MPS platforms have the potential to provide high throughput medical countermeasure screening and high content data for various endpoints and physiological systems prior to moving to in vivo models. These endpoints have significant value for disease modeling and treatment on Earth as well as enabling new approaches to mitigating risks to humans in space. The advanced 3D tissues and MPS models utilize human derived cells and may serve as a bridge for animal to human translation between species. In order to take advantage of 3D tissues and MPS for medical countermeasure screening, 3D tissues and MPS need to be validated against human clinical measures.
The objectives of this meeting are: 1) to develop a better understanding of the state of the science in 3D tissues and MPS, 2) identify specific topic areas where 3D tissues and MPS may meet various Interagency needs and 3) discuss potential partnerships across agencies that may benefit from leveraging resources to pursue activities in this area.
Host contact details:
NCATS: Lucie Low, PhD - lucie.low@nih.gov
NASA: Lisa Carnell, PhD - lisa.a.scottcarnell@nasa.gov
NCATS_NASA 3D tissues meeting booklet_Dec2018.pdfMeeting Booklet
This document contains the meeting agenda, contact information and presentation abstracts.
3-D Tissue Model System
Abaci_NASANIH_2018.pdfBuilding 3-D Skin with Anatomical Features
Hasan Erbil Abaci, Ph.D. (Columbia)
NASA-NCATS Workshop Truskey.pdfHuman Vascular Microphysiological Systems for Diseases Modeling
George A. Truskey,Ph.D. (Duke)
Hartung-Washington-NASA-NCATS-2018-5b.pdfBrain Microphysiological Systems as Verstaile Tools for Brain Research
Thomas Hartung, Ph.D. (Johns Hopkins)
3D Organ Systems on Chips
AtalaNASA.NIH30'.pdfMultiple Tissue-Equivalent Biosensing Platform
Anthony Atala, Ph.D. (Wake Forest)
PrantilBaun.NASA NCATS 3D Wkshp.Final.pdfHuman Organ on Chips for Drug Discovery and Development
Rachelle Prantil-Baun, Ph.D. (Wyss Institute)
Taylor-NASA - for pdf.pdfA Human, Vascularized Liver Acinus Microphysiology Stems (vLAMPS) Experimental Model to Develop Theraputic Strategies for Liver Diseases
D. Lansing Taylor, Ph.D. (Pittsburgh)
Organ Diseases on Chips
PrantilBaun.NASA NCATS Radiation Models Final.pdfHuman Organs on Chips for Testing Radiation Countermeasures
Rachelle Prantil-Baun, Ph.D. (Wyss Institute)
Challenges in Scaling Multi-MPS _ for Disease Modeling Redacted.pdfChallenges in Scaling Multi-MPS for Disease Modeling: Drugs, Inflammation and Metabolism
Martin Trapecar, Ph.D. (MIT)
Hesperos NASA Talk 12-4-18 Modified.pdfUtilizing Multi-Organ Human on a Chip Systems to Predict In Vivo Outcomes for Efficacy and Toxicity
James J. Hickman, Ph.D. (UCF)
Space Medicine
StateOfScience2018DEC04_share_compress.pdfHuman Emulation on the International Space Station: A Platform for Studying Human Biology in Microgravity
Jordan Kerns, Ph.D. (Emulate)
NASA NIH workshop 2018 - large format.pdfKidney on a Chip and Related Tissue Engineering Technologies: Current State of the Art
Jonathan Himmelfarb, M.D. (U Washington)
Roberts ISSNL Chips In Space_NASAHQ wokshop_181204.pdfChips in Space for Life on Earth - Using the ISS National Lab to Accelerate Medical Discovery
Michael Roberts, Ph.D. (CASIS)