ANTIMICROBIAL UTILISATION DATA
ANTIMICROBIAL UTILISATION DATA
Surveillance of antimicrobial use can provide insights on how antimicrobials are being utilised in healthcare settings. Data from antimicrobial utilisation surveillance are useful tools to inform therapy decisions, to assess the public health consequences of antimicrobial misuse, and to evaluate the impact of resistance containment interventions. Information on antimicrobial utilisation is essential in the development of strategies for a more judicious use of antimicrobials.
National-level surveillance of antibiotic utilisation was initiated in selected Malaysian hospitals in 2001. It currently encompasses designated hospitals under the Ministry of Health (MoH), Ministry of Higher Education (MoHE), Ministry of Defence (MinDef), as well as selected private hospitals. The scope of surveillance was expanded in July 2015 to include primary care facilities, specifically MoH health clinics. In 2020, the surveillance further broadened to incorporate antifungal utilisation data from several MoH hospitals. This programme is now collectively referred to as the National Surveillance on Antimicrobial Utilisation (NSAU).
Data were categorised into two main groups—All Wards (excluding ICU) and ICU—to enable more targeted analysis of antimicrobial utilisation patterns in critical care settings. Antimicrobial use was reported using standardised usage density rates, expressed in defined daily doses (DDDs) according to the World Health Organization’s Anatomical Therapeutic Chemical (ATC) classification system. This methodology facilitates meaningful comparisons at the state, national, and regional levels. The surveillance covered the utilisation of 14 selected antibiotics and 3 antifungals in hospitals, and 3 antibiotics in health clinics, for the period of January to December each year.
OVERALL ANTIMICROBIAL UTILISATION TREND 2020-2024 (ALL WARDS)
In 2024, the overall utilisation of antimicrobials in All Wards showed a slight decrease of 1% compared to 2023. However, the utilisation of cephalosporins and polypeptides increased by 3% and 21%, respectively, indicating upward trends in these antimicrobial classes.
OVERALL ANTIMICROBIAL UTILISATION TREND 2020-2024 (ICU)
A steady decline in antimicrobial utilisation has been observed over the past three years, beginning in 2021. In 2024, most antimicrobial groups demonstrated reductions of more than 20% in ICU settings, contributing to an overall 29% decrease in utilisation for that year.
OVERALL ANTIMICROBIAL UTILISATION TREND 2019-2024 (PRIMARY CARE)
The overall antibiotic utilisation trend shows a marked reduction in the mean DDD for ESS by 52% in 2020 and further dropped by 55% in 2021, remaining relatively low thereafter with minor fluctuations, ending at 0.25 in 2024. Cefuroxime usage remained consistently low throughout the period, ranging from mean DDD of 0.24 to 0.13, with a gradual decrease after 2021. Azithromycin utilisation was only incorporated into monitoring in 2024; therefore, only a single data point is available for this period. The recorded mean DDD in 2024 was 0.04.
Cephalosporins Utilisation (2020-2024)
Fluoroquinolones Utilisation (2020-2024)
Carbapenems Utilisation (2020-2024)
Vancomycin Utilisation (2020-2024)
Polypeptide Utilisation (2020-2024)
Piperacillin/Tazobactam Utilisation (2020-2024)
Fluconazole Utilisation (2020-2024)
Echinocandin Utilisation (2023-2024)
Echinocandin antifungals were incorporated into the surveillance beginning in 2023.