Publications

Publications while at Miami University, Department of Chemistry & Biochemistry

Barber, T. S., Alumasa, J. N*. Antibiotic-adjuvants abolish resistance conferred by the Staphylococcus aureus erythromycin resistance methyltransferase in an Escherichia coli model. ACS Infectious Diseases. 2025. Doi: https://doi.org/10.1021/acsinfecdis.5c00865.
Esakova, O. A, Warui, D. M, Neti, S. S., Alumasa, J. N., Booker, S. J. Structural basis for catalysis by human lipoyl synthase. Nat. Commun. 2025. 16:6355. Doi: 10.1038/s41467-025-61393-x.
Varshney, A., Alumasa, J. N., Miller, A., Keiler, K. C. A trans-translation inhibitor kills Mycobacterium tuberculosis by targeting ribosomal protein bL12. J. Bacteriology. 2025., 207(10):e0023625. Doi: 10.1128/jb.00236-25.
Schmidt, A. M., Xiong, S., Alumasa, J. N*. Extracts from soil samples around Pennsylvania exhibit potent antibacterial properties against Bacillus anthracis. American Journal of Undergraduate Research. 2024, 21, 27-38. https://doi.org/10.33697/ajur.2024.117.

Publications while at Penn State University, Department of Biochemistry & Molecular Biology

Marathe, N., Nguyen, H. A., Alumasa, J. N., Kuzmishin Nagy, A. B., Vazquez, M., Dunham, C. M., Keiler, K. C. Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not tRNA. mBio. 2023. 14(5):e0146123. doi: 10.1128/mbio.01461-23.
Miller, D. M., Natale, A., McAnulty, T. M., Swope, R. D., McNaughton, E. A., Beckett, A., Snoke, H. E., Schmidt, A. M., Alumasa, J. N*., Xiong, S*. The design and implementation of an interdisciplinary CURE as an alternative option for the general chemistry laboratory course. ACS Journal of Chemical Education. 2022, 99, 2530-2540. doi.org/10.1021/acs.jchemed.1c01179. (*Corresponding author).
Aron, Z. D., Mehrani, A., Hoffer, E. D., Connolly, K. L., Torhan, M. C., Alumasa, J. N., Srinivas, P., Cabrera, M., Hosangadi, D., Barbor, J. S., Cardinale, S., Kwasny, S., Butler, M., Opperman, T., Bowlin, T., Jerse, A., Stagg, S. M., Dunham, C. M., Keiler, K. C. trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nature Communications. 2021, 12, 1799. doi: 10.1038/s41467-021-22012-7.
Simonson, A. W., Mongia, A. S., Aronson, M. R., Alumasa, J. N., Chan, D. C., Lawanprasert, A., Howe, M. D., Bolotsky, A., Mal, T. K., George, C., Ebrahimi, A., Baughn, A. D., Proctor, E. A., Keiler, K. C., Medina, S. H. Pathogen-specific de novo antimicrobials engineered through membrane protein biomimicry. Nature Biomedical Engineering. 2021. 5, 467-480. doi: 10.1038/s41551-020-00665-x.
Zaman, K. A., Wu, X., Hu, Z., Yoshida, W., Hou, S., Saito, J., Avad, K. A., Hevener, K. E., Alumasa, J. N., Cao, S. Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701. Phytochemistry. 2021, 181, 112545. doi: 10.1016/j.phytochem.2020.112545.
Christoph Senges, C., Stepanek, J., Wenzel, M., Raatschen, N., Ay, U., Märtens, Y., Prochnow, Melissa Vázquez Hernández, P., Yayci, Y., Schubert, B., Janzing, N., Warmuth, H., Kozik, M., Bongard, J., Alumasa, J., Albada, B., Penkova, M., Lukežič, T., Sorto, N., Lorenz, N., Miller, R., Zhu, B., Brenda, M., Stülke, J., Schäkermann, S., Leichert, L., Scheinpflug, K., Brötz-Oesterhelt, H., Hertweck, C., Shaw, J., Petkovic, H., Brunel, J., Keiler, K., Metzler-Nolte, N., Bandow, J.. Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation. Antimicrobial Agents and Chemotherapy. 2020, 65(1):e01373-20. doi: 10.1128/AAC.01373-20.
Huang, Y., Alumasa, J. N., Callaghan, L. T, Baugh, S. R., Rae, C. D., Keiler, K. C., McGillivray, S. M. A Small-Molecule Inhibitor of trans-Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides to Impair Survival of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 2019, 63, e02362-18. doi: 10.1128/AAC.02362-18.
Alumasa, J. N., Goralski, T. D., Keiler, C. K. Tetrazole-based trans-translation inhibitors kill Bacillus anthracis spores to protect host cells. Antimicrobial Agents and Chemotherapy. 2017, doi: 10.1128/AAC.01199-17.
Alumasa, J. N., Manzanillo, P. S., Peterson, N. D., Lundrigan, T., Baughn, A. D., Cox, J. S. & Keiler, K. C. Ribosome rescue inhibitors kill actively growing and non-replicating persister Mycobacterium tuberculosis cells. ACS Infectious Diseases. 2017, 3, 634 - 44. doi.org/10.1021/acsinfecdis.7b00028.
Goralski, T. D., Dewan, K., Alumasa, J. N., Avanzato, V., Place, D., Markley, R., Katkere, B., Rabadi, S., Bakshi, C., Keiler, C. K., Kirimanjeswara, G. Inhibitors of ribosome rescue arrest growth of Francisella tularensis at all stages of intracellular replication. Antimicrobial Agents and Chemotherapy. 2016. 60, 3276-82. doi: 10.1128/AAC.03089-15.
Alumasa, J. N., Keiler, K. C. Clicking on trans-translation drug targets. Frontiers in Microbiology. 2015. 6:498. doi: 10.3389/fmicb.2015.00498.
El-Mowafi, S. A., Sineva, E., Alumasa, J. N., Nicoloff, H., Tomsho, J. W., Ades, S. E., Keiler, K. C. Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay. Antimicrobial Agents and Chemotherapy. 2015, 59, 193-205. doi: 10.1128/AAC.03979-14.
El-Mowafi, S. A., Alumasa, J. N., Ades, S. E., Keiler, K. C. Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway. Antimicrobial Agents and Chemotherapy. 2014, 58, 5500-9. doi: 10.1128/AAC.03311-14.
Ramadoss N. S., Alumasa, J. N., Cheng, L., Wang, Y., Li, S., Chambers, B. S., Chang, H., Chatterjee, A. K., Brinker, A., Engels, I, H., Keiler, K. C. Small molecule Inhibitors of trans-translation have broad-spectrum antibiotic activity. Proceedings of the National Academy of Sciences. U.S.A. 2013, 110, 10282-7. doi: 10.1073/pnas.1302816110.
Keiler K. C., Alumasa J. N. The potential of trans-translation inhibitors as antibiotics. Future Microbiology. 2013, 8, 1235-7. doi: 10.2217/fmb.13.110.
McGillivray, S. M., Tran, D. N., Ramadoss, N. S., Alumasa, J. N., Okumura, C. Y., Sakoulas, G., Vaughn, M. M., Zhang, D. X., Keiler, K. C., Nizet, V. Pharmacological Inhibition of the ClpXP Protease Increases Bacterial Susceptibility to Host Cathelicidin Antimicrobial Peptides and Cell Envelope-Active Antibiotics. Antimicrobial Agents and Chemotherapy. 2012, 56, 1854-61. doi: 10.1128/AAC.05131-11.

Publications while at Georgetown University, Department of Chemistry

Gorka, A. P., Alumasa, J. N*., Sherlach, K., Jacobs, L., Nickley, K., Brower, J., de Dios, A., Roepe, P. D. In Vitro Cytostatic and Cytocidal Activity of Quinoline Antimalarial Drugs vs. Inhibition of Hemozoin Crystal Growth. Antimicrobial Agents and Chemotherapy.2013, 57, 356-64. doi: 10.1128/AAC.01709-12.
Pan, E., Gorka, A. P., Alumasa, J. N., Slebodnick, C., Harinantenaina, L., Brodie, P. J., Roepe, P. D., Randrianaivo, R., Birkinshaw, C., Kingston, D. G. Antiplasmodial and antiproliferative pseudoguaianolides of Anthroisma proteiforme from Madagascar Dry Forest. Journal of Natural Products. 2011, 74, 2174-80. doi: 10.1021/np200499d.
Alumasa, J. N., Gorka, A. P., Casabianca, L. B., Comstock, E., de Dios, A. C., Roepe, P. D. The Hydroxyl functionality and a proximal N are required for forming a novel non-covalent quinine- heme complex. Journal of Inorganic Biochemistry. 2011, 105, 467-75. doi: 10.1016/j.jinorgbio.2010.08.011.
Iwaniuk, D. P., Whetmore, E. D., Rosa, N., Ekoue-Kovi, K., Alumasa, J., de Dios, A. C., Roepe, P. D., Wolf, C. Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain. Bioorganic & Medicinal Chemistry. 2009, 17, 6560-6. doi: 10.1016/j.bmc.2009.08.003.
Hou, Y., Cao, S., Brodie, P. J., Callmander, M. W., Ratovoson, F., Rakotobe, E., Rasamison, V. E., Ratsimbason, M., Alumasa, J. N., Roepe, P. D., Kingston, D. G. I. Antiproliferative and antimalarial anthraquinones of Scutia myrtina from the Madagascar forest. Bioorganic & Medicinal Chemistry. 2009, 17, 2871-6. doi: 10.1016/j.bmc.2009.02.022.
Casabianca, L. B., Kallgren, J. B., Natarajan, J. K., Alumasa, J. N., Roepe, P. D, Wolf, C., de Dios, A. C. Antimalarial drugs and heme in detergent micelles: An NMR study. Journal of Inorganic Biochemistry. 2009, 103, 745-8. doi: 10.1016/j.jinorgbio.2009.01.013.
Ekoue-Kovi, K., Yearick, K., Iwaniuk, D. P., Natarajan, J. K., Alumasa, J., de Dios, A. C., Roepe, P. D., Wolf, C. Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas. Bioorganic & Medicinal Chemistry. 2009, 17, 270-83. doi: 10.1016/j.bmc.2008.11.009.
Casabianca, L. B., An, D., Natarajan, J. K., Alumasa, J. N., Roepe, P. D., Wolf, C., de Dios, A. C. Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium. Journal of Inorganic Chemistry. 2008, 47, 6077-81. doi: 10.1021/ic800440d.
Natarajan, J. K., Alumasa, J. N., Yearick, K., Ekoue-Kovi, K. A., Casabianca, L. B., de Dios, A. C., Wolf, C., Roepe, P. D. 4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs. chloroquine resistant malaria. Journal of Medicinal Chemistry. 2008, 51, 3466-79. doi: 10.1021/jm701478a.
Yearick, K., Ekoue-Kovi, K., Iwaniuk, D. P., Natarajan, J. K., Alumasa, J., de Dios, A. C., Roepe, P. D., Wolf, C. Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines. Journal of Medicinal Chemistry. 2008, 51, 1995-8. doi: 10.1021/jm800106u.

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