Experimental and computational approaches to study protein structure and function
The goal of this course is to provide an introduction to protein structure and function. The main topics of the course are:
- The main features that determine protein structure.
- How does the sequence of a protein define its structure?
- Prediction of protein structure
- Protein design
- Protein function & prediction of protein function based on sequence and structure
- Protein-DNA recognition.
The course is accompanied by weekly exercises that allow the students to get hands-on experience about the taught material.
Experimental and computational approaches to study protein-protein interactions
Protein-protein interactions and interactions with other molecules are a central component of cells. This course is designed to present an overview of different levels of interactions and networks of interactions that characterize cellular function. The vast data about interactions that has accumulated lately from high-throughput methods will be described, and tools to analyze these data. Recent successes in manipulation of protein-protein interactions by experiment or by computer-guided approaches will be introduced and practiced by hands-on examples.
Computational approaches to structure prediction and design of proteins
During the course we will explore concepts and algorithms that enable computational modeling of biological molecules, in both theory and practice. In this framework, We will learn to use Rosetta, one of the leading protein modeling suites. These methods are applied in predicting protein structure, docking multiple proteins into complexes, designing new proteins for medical or industrial purposes, and other cutting-edge scientific research.
Clinical and scientific implication of the genomic revolution (part of 94615)
Introduction to Proteomics
The aim of this course is to gain a deep knowledge of the changes in the scientific thinking in biology that occurs due to the development of new genomic tools. This will be achieved through the discussion of a variety of examples of studies using these tools. I am teaching the part on proteomics. The course will provide an overview of the following topics:
- The basic concepts of proteomics
- The tools that allow studying proteomics
- The type of knowledge that can be achieved by proteomics techniques.
- Key proteomic studies and their findings