Articles and Grants

PEER-REVIEWED PUBLICATIONS

• 1. Yedjou CG*, Njiki S, Enow J, Ikome O, Latinwo L, Long R, Ngnepieba P, Alo RA*, and Tchounwou PB. Pharmacological Effects of Selected Medicinal Plants and Vitamins Against COVID-19. 2021; J Food Nutr 7: 1-16.

  2. Yedjou CG*, Richard A. Alo RA, Liu J, Enow J, Ngnepiepa P, Long R, Latinwo L, Tchounwou PB. Chemo-Preventive Effect of Vegetables and Fruits Consumption on the COVID-19 Pandemic. J Nutr Food Sci. 2021; 4: 029.

  3. Ariane Mbemi, Khanna S, Njiki S, Yedjou CG, Tchounwou PB. Impact of Gene-Environment Interactions on Cancer Development. Int. J. Environ. Res. Public Health 2020, 17(21), 8089;

  4. Dasari S, Yedjou CG, Brodell RT, Cruse A, Tchounwou PB. Therapeutic strategies and potential implications of silver nanoparticles in the management of skin cancer.  Nanotechnology Reviews 2020; 9: 1500–1521.

  5. Yedjou CG*. Novel Therapeutic Anticancer Property of Vernonia amygdalina Delile Towards the Treatment of Prostate Cancer. Journal of Pharmaceutical Toxicology 2020; 3(4), 6.

  6. Mbemi AT, Sims JN, Yedjou CG*, Noubissi FK, Gomez CR, Tchounwou PB. Vernonia calvoana Shows Promise Towards the Treatment of Ovarian Cancer. Int. J. Mol. Sci. 2020, 21, 4429; doi:10.3390/ijms21124429

  7. Yedjou CG*, Mbemi AT, Noubissi F, Tchounwou SS, Tsabang N, Payton M, Miele L, Tchounwou PB. Prostate cancer disparity, chemoprevention, and treatment by specific medicinal plants. Nutrients. 2019, 11(2), 336; https://doi.org/10.3390/nu11020336. PMID: 30720759

  8. Tchounwou PB, Yedjou CG, Udensi UK, Pacurari M, Stevens JJ, Patlolla AK, Noubissi F, Kumar S. State of the Science Review of the Health Effects of Inorganic Arsenic: Perspectives for Future Research. Environmental Toxicology. 2018. https://doi.org/10.1002/tox.22673.

  9. Yedjou CG*, Tchounwou SS, Williams K, Tchounwou PB. Novel Cellular Staining Protocol and Antiproliferative Effect of Vernonia Amygdalina Delile on Lung and Prostate Cancer Cells. Int J Eng Sci Res Technol.  2018.  PMCID: PMC6149525.

  10. Yedjou CG*, Sims JN, Njiki S, Tsabang N, Ogungbe IV, Tchounwou PB. Vernonia amygdalina Delile Exhibits Potential for the treatment of Acute Promyelocytic Leukemia. Glob J Adv Eng Technol Sci. 2018; 5(8): ISSN 2349-0292.  DOI: 10.5281/zenodo.1343591.

  11. Noubissi FN, Yedjou CG, Vladimir S. Spiegelman VS, Tchounwou PB. Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma. Int J Environ Res Public Health. 2018, 15(17), 1442. PMCID: PMC6069411.

  12. Sims JN, Yedjou CG*, Abugri D, Payton M, Turner T, Lucio Miele  L,  Tchounwou PB. Racial Disparities and Preventive Measures to Renal Cell Carcinoma. Int. J. Environ. Res. Public Health 2018, 15(6), 1089. PMCID: PMC6024978.

  13. Johnson W, Tchounwou PB, Yedjou CG*. Therapeutic Mechanisms of Vernonia amygdalina Delile in the Treatment of Prostate Cancer. Molecules. 2017, 22(10), 1594. PMCID: PMC5661957.

  14. Tsabang N, Yedjou CG, Tchounwou PB. Phytotherapy of High Blood Pressure in Three Phytogeographic Regions of Cameroon.  Pharm Anal Acta. 2017, 8:1. PMCID: PMC5648011.

  15. Yedjou CG*, Tchounwou PB, Payton M, Miele L, Fonseca DD, Lowe L, Alo’ RA. Assessing the Racial and Ethnic Disparities in Breast Cancer Mortality in the United States.  Int J Environ Res Public Health. 2017, 14, 486. PMCID: PMC5451937. 

  16. Tsabang N, Atsamo A, Tsambang LWD, Tsafack JE, Donfagsiteli N, Yedjou CG, Tchinda TA, Agbor GA, Tchounwou PB. Medicinal Uses and Natural Availability of Three Plant Species in Selected Ecosystems in Cameroon. J Anal Pharm Res. 2017, 4(4): 00109. PMCID: PMC5663298.

  17. Tsabang N, Tsambang LWD, Yedjou CG, Tchounwou PB. Socio-cultural contribution to medicinal plants assessment and sustainable development: case of antidiabetic and antihypertensive plants in Cameroon. Glob Drugs Therap, 2017, 2(1): 1-6. PMCID: PMC5995558.

  18. Dugo EB, Yedjou CG, Stevens JJ, Tchounwou PB. Therapeutic Potential of Arsenic Trioxide (ATO) in Treatment of Hepatocellular Carcinoma: Role of Oxidative Stress in ATO-Induced Apoptosis. Ann Clin Pathol, 2017, 5(1): 1101. PMCID: PMC4983967.

  19. Tsabang N, Fongnzossie E, Donfack D, Yedjou CG, Tchounwou PB, Minkande JZ, Nouedou C, Van PD, Sonwa. Comparative Study of Epidemiological and Anthropological Aspects of Diabetes and Hypertension in Cameroon. Forest Research. 2016, 5:1. PMCID: PMC5047516.

  20. Skipper A, Sims JN, Yedjou CG, Tchounwou PB. Cadmium Chloride Induces DNA Damage and Apoptosis of Human Liver Carcinoma Cells via Oxidative Stress. Int J Environ Res Public Health. 2016, 13(1). PMCID: PMC4730479.

  21. Yedjou CG*, Tchounwou HM, Tchounwou PB. DNA Damage, Cell Cycle Arrest, and Apoptosis Induction Caused by Lead in Human Leukemia Cells. Int J Environ Res Public Health. 2015. 13(1). PMCID: PMC4730447.

  22. Kirui PK, Yedjou CG*, Isopehi R, Tchounwou PB. Impact of Aflatoxins Contamination on Food Security and Human Health in Kenya. Journals of Cancer Science and Research. 2015. Accepted.

  23. Blocka KI, Gyllenhaal C, Lowe L, Amedei A, Yedjou CG et al.  A broad-spectrum integrative design for cancer prevention and therapy. Seminar Cancer Biology.  2015,

  24. Dasari SR, Velma V, Yedjou CG, Tchounwou PB. Preclinical Assessment of Low Doses of Cisplatin in the Management of Acute Promyelocytic Leukemia. Int J Cancer Res Mol Mech. 2015, 1(3): PMCID: PMC4758698.

  25. Tsabang N, Yedjou CG, Tsambang LWD3, Tchinda AT, Donfagsiteli N , Agbor GA , Tchounwou PBB, Nkongmeneck BA. Treatment of Diabetes and/or Hypertension Using Medicinal Plants in Cameroon.  Med Aromat Plants. 2015, S2:003. doi:10.4172/2167-0412.S2-003. PMCID: PMC4636212.

  26. Tsabang N, Kadjob S , Mballa RN, Yedjou CG, Nnanga N, Donfagsiteli NT ,  Tchinda AT , Agbor GA, Ntsama C,  Tchounwou PB. New Approach for the Development of Improved Traditional Medicine: Case of a Preparation of an Oral Hypoglycemic Medicine from Laportea ovalifolia (Schumach. & Thonn.) Chew. (Urticaceae). J Mol Pharm Org Process Res.  2015, 3: 125. PMCID: PMC4636220.

  27. Yedjou CG*, Cameron J, Mbemi TA, Tchounwou PB. β-Estradiol Induces Cytotoxic Effects to Human T-Lymphoma (Jurkat) Cells through Oxidative Stress. Journal of Mississippi Academy of Sciences. 2015, 60(1):279-283. PMCID: PMC4550313.

  28. Narayanan KB, Ali M, Barclay BJ, Cheng Q, D'Abronzo L, Dornetshuber-Fleiss R, Ghosh PM, Gonzalez Guzman MJ, Lee TJ, Leung PS, Li L, Luanpitpong S, Ratovitski E, Rojanasakul Y, Romano MF, Romano S, Sinha RK,  Yedjou CG et al., Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis. 2015, 36 Suppl 1:S89-S110. PMCID:PMC4565614

  29. Mohammad RM, Muqbil I, Lowe L, Yedjou CG, Hsu HY et al. Broad targeting of resistance in apoptosis. Seminars in Cancer Biology. 2015, 1-26. PMCID: PMC4720504.

  30. Goodson III WH, Lowe L, Carpenter DO, Yedjou CG et al. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015, 1-43. PMCID: PMC4480130.

  31. Tchounwou PB, Udensi KU, Isopehi RD, Yedjou CG, Kumar S. Arsenic and cancer. Handbook of Arsenic Toxicology. 2015, 533-556.

  32. Kumar S, Yedjou CG, Tchounwou PB. Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells.   J Exp Clin Cancer Res. 2014, 33(1): 42. PMCID: PMC4049373.

  33. Tchounwou CK, Yedjou CG*, Farah IO, Tchounwou PB. D-Glucose induced cytotoxic, genotoxic, and apoptotic effects on human breast adenocarcinoma (MCF-7) cells. J Cancer Sci Ther. 2014; 6:156-160.  PMCID: PMC4264661.

  34. Rogers CS, Yedjou CG, Sutton DJ, Tchounwou PB. Vitamin D3 potentiates the antitumorigenic effects of arsenic trioxide in human leukemia (Hl-60) cells. Journal of Experimental Hematology & Oncology. 2014, 3:9. PMCID: PMC3973008.

  35. Yedjou CG*, Izevbigie EB, Tchounwou PB. Vernonia amygdalina-Induced Growth Arrest and Apoptosis of Breast Cancer (MCF-7) Cells. Pharmacology & Pharmacy, Vol. 4 No. 1, 2013, pp. 93-99. PMCID: PMC3864043.

  36. Yedjou CG*, Saeed MA, Md. Hossain A, Dorsey W, and Yu H, and Tchounwou PB.  Basic apoptotic and necrotic cell death in human liver carcinoma (HepG2) cells induced by synthetic azamacrocycle. Environ Toxicol. 2012 May 30. PMID: 22644747.

  37. Yedjou CG*, Tchounwou. In vitro assessment of oxidative stress and apoptotic mechanisms of garlic extract in the treatment of acute promyelocytic leukemia. Journal of Cancer Science and Therapy. 2012. 10(4):1948-1956. PMCID: PMC3705777.

  38. Yedjou CG*, Tchounwou PB. Lead-induced cell cycle arrest in human liver carcinoma (HepG2) cells: involvement of oxidative stress, p53 and cyclin A. Metal Ions in Biology and Medicine. 2011; 11:242-246. NIHMSID # 310499.

  39. Yedjou CG*, Byrd R, Allen L, Tchounwou PB. Physiologic doses of ascorbic acid increase arsenic trioxide in human Jurkat T lymphoma cells. Metal Ions in Biology and Medicine. 2011; 11:236-241. NIHMSID # 310486.

  40. Wang Y, Aker WG, Hwang HM, Yedjou CG, Yu H, Tchounwou PB. A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ. 2011 Aug 16.  PMCID: PMC3185176.

  41. Edwards FL, Yedjou CG, Tchounwou PB. Involvement of oxidative stress in methyl parathion and parathion-induced toxicity and genotoxicity to human liver carcinoma (HepG2) cells. Environ Toxicol. 2011 May 4. [Epub ahead of print]. PMCID: PMC3768275.

  42. Skipper A, Tchounwou PB, Yedjou CG. In vitro mechanisms of cadmium-induced apoptosis in human liver carcinoma (HEPG2) cells. Cancer Prevention Research, 2010; 3(1):39. 

  43. Yedjou CG*, Tchounwou PB, Jerkens J, and McMurray. Basic mechanisms of arsenic trioxide (ATO)-induced apoptosis in human leukemia (HL-60) cells. Journal of Hematology and Oncology. 2010, 3:28. PMCID: PMC2939535.

  44. Yedjou C*, Milner J, Howard C, and Tchounwou P. Basic apoptotic mechanisms of lead toxicity in human leukemia (HL-60) cells.  Int. J. Environ. Res. Public Health. 2010; 7(5), 2008-2017. PMCID: PMC2898032.

  45. Yedjou CG, Tchounwou CK, Haile S, Edwards F, Tchounwou PB. N-acetyl-cysteine (NAC) protects against DNA damage associated with lead toxicity in HepG2 cells. Disease and Ethnicity. 2010; 20, 101-103. PMCID:  PMC2902977.

  46. Moore P, Yedjou CG, and Tchounwou PB. Malathion-Induced Oxidative Stress, Cytotoxicity and Genotoxicity in Human Liver Carcinoma (HepG2) Cells. Environ Toxicol. 2010; 25(3):221-6. PMCID: PMC2862833.

  47. Yedjou CG, Thuisseu LD, Tchounwou CK, Gomes M, Howard C, and Tchounwou PB. Ascorbic acid potentiation of arsenic trioxide anticancer activity against acute promyelocytic leukemia. Archives of Drug Information. 2009; 2(4): 59-65. PMCID: PMC2805867.

  48. Yedjou CG*, and Tchounwou PB. Arsenic trioxide-induced modulation of p53, c-fos, RARE, cyclin D1, and cyclin A in human leukemia (HL-60) cells. Molecular and Cellular Biochemistry. 2009; 331(1-2): 207-214. PMCID:  PMC2855208.

  49.  Patlolla AK, Barnes C, Yedjou CG, Velma VR, Tchounwou PB. Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats. Environ Toxicol. 2009; 24(1):66-73. PMCID: PMC2769560.

  50. Yedjou C*, Izevbigie E, Tchounwou P. Preclinical assessment of Vernonia amygdalina leaf extracts as DNA damaging anti-cancer agent in the management of breast cancer. Int J Environ Res Public Health. 2008; 5(5):337-41. PMCID: PMC3699992.

  51. Yedjou CG*, Waters D, Tchounwou P.B. N-acetyl-cysteine protection against lead-induced oxidative stress and genotoxicity in human liver carcinoma (HepG2) cells. Metal Ions Biol. Med. 2008; 10, 419-424. NIHMSID # 354248.

  52. Yedjou CG, Haynes L, Dorsey D, McMurray M, and Paul B. Tchounwou PB. Lead-Induced Cytotoxicity and Oxidative Stress in Human Leukemia (HL-60) Cells. Metal Ions Biol. Med. 2008; 10, 417-420. NIHMSID # 354207.

  53. Clement G. Yedjou, Daren Waters, Paul B. Tchounwou. Protection from Lead Genotoxicity by N-Acetyl-cysteine in Human Liver Carcinoma (HepG2) Cells. Metal Ions Biol. Med. 2008; 10, 421-424. NIHMSID # 113144.

  54. Yedjou CG, Brown E, Rogers C, Tchounwou PB. Ascorbic acid - modulation of arsenic trioxide toxicity: Implication for the clinical treatment of acute promyelocytic leukemia.  Metal Ions Biol. Med. 2008; 10, 417-420.  NIHMSID # 354266.

  55. Yedjou CG, Sutton L, Tchounwou P.B. Genotoxic mechanisms of arsenic trioxide effect in human Jurkat T-lymphoma cells.  Metal Ions Biol. Med. 2008; 10, 495-499. PMCID: PMC3142934.

  56. Brown E, Yedjou C.G, Tchounwou P.B. Oxidative stress in human liver carcinoma cells exposed to arsenic trioxide (HepG2). Metal Ions Biol. Med. 2008; 10, 583-587. PMCID: PMC2908498.

  57. Yedjou CG, Rogers C, Brown E, and Tchounwou PB. Differential effect of ascorbic acid and n-acetyl-l-cysteine on arsenic trioxide mediated oxidative stress in human leukemia (HL-60) cells. Biochemical and Molecular Toxicology. 2008; 22(2), 85-92.  PMCID: PMC2678234.

  58. Yedjou CG, and Tchounwou PB. N-acetyl-l-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. Int. J. Environ. Res. Public Health.  2007. 4(2), 132-137. PMCID: PMC3728578.

  59. Yedjou CG, and Tchounwou PB. In-vitro genotoxic effect of arsenic trioxide to human leukemia (HL-60) cells using the comet assay. Molecular and Cellular Biochemistry. 2007; 301(1-2), 123-130. PMID: 17216127 [PubMed].

  60. Yedjou CG, and Tchounwou PB. Oxidative stress in human leukemia (HL-60), human liver carcinoma (HepG2), and human Jurkat T-cells exposed to arsenic trioxide. Metal Ions Biol. Med. 2006; 9, 298-303.

  61. Yedjou CG, Moore M, and Tchounwou PB. Dose and time-dependent response of human acute promyelocytic leukemia HL-60 cells to arsenic trioxide treatment. Int. J. Environ. Res. Public Health. 2006; 3 (2), 136-140. PMCID: PMC3807505

  62. Yedjou CG, Steverson M, and Tchounwou PB. Lead nitrate-induced oxidative stress in human liver carcinoma (HepG2) cells. Metal Ions Biol. Med. 2006; 9, 293-297.

  63. Tchounwou PB, Yedjou CG, Foxx DN, Ishaque AB, and Shen E. Lead-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells. Molecular and Cellular Biochemistry. 2004; 255: 161-170. PMID: 14971657 [PubMed].

  64. Tchounwou PB, Yedjou CG, and Dorsey WC. Arsenic trioxide-induced transcriptional activation and expression of stress genes in human liver carcinoma cells (HepG2). Cellular and Molecular Biology. 2003; 49 (7), 1071-1079. PMID: 14682389 [PubMed].

BOOK CHAPTERS

• 1. Tchounwou PB, Udensi K., Isokpehi RD, Yedjou CG, Kumar S. Arsenic and cancer. Handbook of Arsenic Toxicology, 2nd Edition, 2023; 607-630.

  2. Yedjou CG*, Latinwo L, Alo RA, Odewomi C, and Reaves P. Technology Enhanced Student Learning, Improved Engagement, and Performance in an Anatomy and Physiology Course: Engagement Student Learning Using Innovative Technologies. IGI Global, 2022. ISBN: 9781668453360.

  3. Yedjou CG*, Sims SN, Miele L, Noubissi N, Lowe L, Fonseca-Gomez D, Alo RA, Payton M, Tchounwou PB. Health and Racial Disparity in Breast Cancer. Adv Exp Med Biol, 2019; Vol. 1152,: Breast Cancer Metastasis and Drug Resistance, 978-3-030-20300-9, 299487_2_En, (3).

  4. Abugri DA, Ayariga JA, Tiimob BJ, Yedjou CG, Mrema F, Witola WH. Medicinal Mushrooms as Novel Sources for New Antiparasitic Drug Development. Medicinal Mushrooms. Springer Nature. ISBN:978-981-13-6381-8.

  5. Yedjou CG*, Tchounwou HM, and Tchounwou PB. DNA Damage, Cell Cycle Arrest, and Apoptosis Induction Caused by Lead in Human Leukemia Cells. Top 10 Contributions on Environmental Health. 2018.  http://www.avidscience.com

  6. Yedjou CG*, Shivers M, Kirui P, Mbemi AT, Dasari S, Noubissi-Kamdem F, and Tchounwou PB. 2016. A Broad Approach for the Management of Acute Promyelocytic Leukemia.  SMGroup. 2016.

  7. Tchounwou PB, Patlolla AK, Yedjou CG, and Moore PD. 2015. Environmental Exposure and Health Effects Associated with Malathion Toxicity.  InTech Journals. 2015. ISBN 978-953-51-2145-9.

  8. Tchounwou PB, Udensi UK, Isokpehi RD, Yedjou CG, and Kumar S. 2015. Arsenic and Cancer. In: Handbook of Arsenic Toxicology, Ed. Flora SJS, 2015. pp 533-549. ISBN: 978-0-12-418688-0.

  9.  Tchounwou PB, Yedjou CG, Patlolla A, Sutton D. 2012. Heavy metals toxicity and the environment. (Online) Molecular, Clinical, and Environmental Toxicology. PP 101:133-164. ISBN: 978-3-7643-8339-8 (Print) 978-3-7643-8340-4.

RESEARCH SUPPORT

NSF- 2142465

NSF-IUSE                                                                        6/15/2022-5/14/2025    1.00 calendar                                           Role: Principal Investigator

Project Title:  Collaborative Research: Distributed Learning Undergraduate Programs in Data Science from Diverse Universities

The goal of this project is to develop and deliver distributed learning courses in Environmental Data Science.

Faculty Research Award Program                                 11/01/2021-10/31/2022     1.00 calendar

Award # 0000005350

Role: Principal Investigator (PI)

Project Title: Molecular Mechanisms of Anticancer Action of Vernonia amygdalina Delile in Prostate Cancer

The goal is to test the therapeutic efficacy of VAD towards the treatment of prostate cancer.

NSF-1900127

NSF                                                                                 8/1/19-7/31/23             1.00 calendar     

Role: Co-Principal Investigator (Co-PI)

Project Title: Stereoselective Synthesis of Spiro-Oxepin Core: Toward the Total Synthesis of Psammaplysin Natural Product and Analogues for Biological Study.

The goal is to use cancer related in vitro assays to determine the anti-neoplastic activity of the identified compounds.

GOOGLE LLC                                                           9/23/20-8/22/2022               0.50 calendar     

Role: Investigator

Project Title: GOOGLE LLC COVID-19 Artificial Intelligence and Data Analytics for Social Good Fund

The goal is to improve health equity and minimize secondary effects of the pandemic and to provide monitoring and forecasting of disease spread. 

COMPLETED RESEARCH SUPPORT  

1R15CA260122-01 

NIH                                                                                  7/01/18-6/30/21             1.00 calendar     

Role: Co-Principal Investigator (Co-PI)

Project Title: A novel approach in Basal Cell Carcinoma treatment; targeting CRD-BP gene.

The goal of this project is to understand the role of CRD-BP in Basal Cell Carcinoma development and progression in vivo.