The Rivera-Chávez laboratory studies fungal natural products at the interface of chemistry and biology. The research is a multidisciplinary project focused on the chemical and pharmacological diversity of molecules produced by fungi, as well as their semisynthetic derivatives. Particularly, we are interested on studying Ascomycetes (Pezizomycotina) obtained from unexplored habitats (wetlands, anthills, and some extreme ecological niches) in Mexico. This project seeks to contribute to the discovery of putative drug leads to treat multi-resistant bacterial infections or type II diabetes mellitus, through the inhibition of proteins involved on replication of bacterial cells (protein FtsZ) or regulation of blood glucose levels and food intake (Protein Tyrosine Phosphatase 1B). Using a combination of analytical methods (Chromatography, Nuclear Magnetic Resonance, Chiroptic, and Mass Spectrometry) Organic Chemistry (Synthesis and semisynthesis), Molecular Biology, Biochemistry, Computational Chemistry, Pharmacology, and Phylogenetics, we aim to contribute to the knowledge of the relationship between the taxonomic distribution of ascomycetes from Mexican wetlands (genotype) with their metabolic potential (chemotype) and bioactivity, by developing a multi-informative approach combining metabolomics, genomics, in vitro biological assays and chemoinformatic techniques to identify and prioritize talented fungal microorganisms for the discovery of novel functional natural products (and analogs), useful as drug leads and/or research tools in several areas of science.