Convenors: Dr. Shankar Manoharan and Dr. Pragyan Acharya
Team members – Dr. Dhiraj Dhotre, Dr. Shweta Ramdas, Dr. Ishaan Gupta, Prof. Nar Singh Chauhan, Prof. Samanwita Pal, Dr. Balakumaran Chandrasekar, Dr. Vignesh Murlidharan, Prof. Mitali Mukerji, Dr. Sonia Velasran
Volunteers – Sachin Rathod, Rishabh Jain
Key Pointers :
How does the Ayurgenomics framework provide the "ground truth" necessary to biologically validate traditional Ayurvedic profiles for a modern medical audience?
How can multi-omic technologies identify "response biomarkers" that prove the efficacy of integrative interventions like specialized diets or meditation?
What is the roadmap for achieving "atomistic resolution" in understanding how poly-pharmacological Ayurvedic formulations interact with biological systems?
This session transitions from digital observation to deep biological validation, focusing on the molecular underpinnings of the PRISM platform. By integrating high-throughput omic technologies, the session aims to substantiate traditional Prakriti profiles with rigorous scientific evidence and spatio-temporal data.
Key Discussion Points:
Biological Validation of Prakriti: Implementing the Ayurgenomics framework to map traditional constitutional types to specific genetic and molecular signatures.
Contextualizing Baseline Data: Leveraging large-scale datasets from the Genome India project and the Human Microbiome Initiative to provide a robust background for personalized health profiling.
Multi-omic Technologies for Precision: Utilizing genomics, metabolomics, and metagenomics to identify specific response biomarkers for clinical interventions.
Host-Microbiome Interactions: Exploring the dynamic relationship between the human microbiome and host physiology to provide spatio-temporal readouts of health status.
Mechanistic Insights: Moving toward an atomistic resolution of how poly-pharmacological Ayurvedic formulations interact with biological systems to restore health.
Physiological Markers of adaptive response to meditation, and dietary interventions as state level regulation
By validating these biological markers, this session provides the essential "ground truth" data required to contextualize Prakriti-Informed Digital Twins, ensuring that PRISM’s recommendations are both scientifically sound and clinically actionable.