Metabolic Disorder and Prameha framework
Metabolic Disorder and Prameha framework
Co-Convenors : Dr. Bharat Padhar, Dr. Ravinder Shukla, Dr. Sudipta Bhattacharya
Discussants - Dr. Shankar Manoharan, Dr. Dhiraj Dhotre, Dr. Balakumaran Chandrasekar, Prof. Samanwita Pal, Dr. Saketh Ram Thrigulla, Prof. Ajay Agarwal, Dr. Manoj Khokhar, Dr. Neha Jain, Dr. Pankaj Yadav
Volunteers - Aditi Joshi, Sachin Rathod, Dr. Sumit
Key Pointers :
Where is the strongest scientific concordance between the traditional Prameha framework and modern pathological classifications of metabolic disease?
How can we design a multi-omic diagnostic panel that effectively monitors disease progression and therapeutic response for both systems?
How can structural biology and genomics be synergized with Ayurvedic formulations to address end-stage complications like Chronic Kidney Disease?
This breakout session focuses on the "Prameha" framework to address the unmet needs in metabolic disorders. Participants will engage in a participatory dialogue to identify how different disciplines—Ayurveda, Multi-omics, and Engineering—can converge to provide a "seamless platter" of evidence-based solutions.
Key Deliberation Points:
Ayurvedic Conceptual Framework: Defining the Prameha framework for metabolic disorders to identify "moving targets" and the traditional hallmarks of effective interventions.
Concordance & Needs Assessment from modern medicine perspective: Analyzing the spectrum of metabolic diseases to find points of scientific concordance between traditional classifications and modern pathology.
Disease Modeling for Biomarkers: Utilizing model systems for MASLD and CKD (Chronic Kidney Disease) to identify specific biomarkers of disease progression and therapeutic response.
Mechanistic Integration: Synergizing the usage perspective of Ayurvedic formulations with genomics and advanced computational/structural biology to treat end-stage complications.
Multi-omic Diagnostics: Designing a panel of metagenomic and multi-omic markers specifically for the diagnosis, monitoring, and intervention of diabetes and related metabolic syndromes.
Roadmap Definition: Collaboratively assessing the technical limitations and strengths of each domain to build a deployable roadmap for integrating metabolic care into the PRISM tool-kit.