The workshop aims to bring stakeholders from diverse disciplines to a common platform for seamless conversations and offer evidence-based solutions for personalized management of health and in disease. By enabling the selection of optimal therapies within a participatory framework, this initiative resonates with the primary aim of Ayurveda: to restore health in the healthy and manage disease in the diseased. A core focus of this gathering is to deliberate on the Prakriti-Informed Digital Twins for Scalable Precision Wellness and Medicine (PRISM) platform.