Publication

From IIT Hyderabad

#: Corresponding author

  1. Deeksha, W., Abhishek, S. & Rajakumara, E.# PAR recognition by multiple reader domains of PARP1 allosterically regulates the DNA-dependent activities and independently stimulates the catalytic activity of PARP1. BioRxiv, 2021.12.21.473685 (2021). (Under review)


  1. Abhishek, S., Deeksha, W. & Rajakumara, E. #. Mechanistic insights into allosteric regulation of methylated DNA and histone H3 recognition by SRA and SET domains of SUVH5 and the basis for di-methylation of lysine residue (Under review in The FEBS Journal).


  1. Satish, M., Kumari, S., Nitin, K., Ninjoor, Y. K., Babu, A., Adiga, S. K., Kalthur, G. # & Rajakumara E.# Computational, biochemical and ex vivo evaluation of xanthine derivatives against phosphodiesterases to enhance the sperm motility (Under Review in Journal of Biomolecular Structure and Dynamics)


  1. Pratibha, M., Abhishek, S. & Rajakumara, E.# Designing ferritin nanocage based vaccine candidates for SARS-CoV-2 by in silico engineering of its MHC I and MHC II epitope peptides, (Under Review in Journal of Biomolecular Structure and Dynamics).


  1. Singh, R., Roopmani, P., Chauhan, M., Basu, S. M., Deeksha, W., Kazem, M. D., Hazra, S., Rajakumara E. & Giri, J.* Silver sulfadiazine loaded core-shell airbrushed nanofibers for burn wound healing application. Int. J. Pharm. 613, 121358 (2022)


  1. Rajakumara, E. #, Abhishek, S., Nitin, K., Saniya, D., Bajaj, P., Schwaneberg, U. & Davari, M. D. # Structure and Cooperativity in Substrate–Enzyme Interactions: Perspectives on Enzyme Engineering and Inhibitor Design. ACS Chem. Biol. (2022) doi:10.1021/acschembio.1c00500.


  1. Mehta, G#., Sanyal, K., Abhishek, S., Rajakumara E. & Ghosh, S. K. # Minichromosome maintenance proteins in eukaryotic chromosome segregation. BioEssays 44, 2100218 (2022).


  1. Satish M, Kumari S, Deeksha W, Abhishek S, Nitin K, Adiga SK, Hegde P, Dasappa JP, Kalthur G#, Rajakumara E#. Structure-based redesigning of pentoxifylline analogs against selective phosphodiesterases to modulate sperm functional competence for assisted reproductive technologies, Nature Scientific Reports 11(1):12293 (2021). https://youtu.be/grUr-9_X7cw


  1. Abhishek S, Deeksha W, Rajakumara E#. Helical and β-Turn Conformations in the Peptide Recognition Regions of the VIM1 PHD Finger Abrogate H3K4 Peptide Recognition. Biochemistry. 60(35):2652-2662 (2021). (Journal Cover-page).


  1. Abhishek S, Nakarakanti NK, Deeksha W, Rajakumara E#. Mechanistic insights into recognition of symmetric methylated cytosines in CpG and non-CpG DNA by UHRF1 SRA. Int J Biol Macromol. 170:514-522 (2021).


  1. Pullaguri N, Grover P, Abhishek S, Rajakumara E, Bhargava Y, Bhargava A#. Triclosan affects motor function in zebrafish larva by inhibiting ache and syn2a genes. Chemosphere. 266:128930 (2021).


  1. Rajakumara E#, Satish M, Abhishek S. In vitro studies on non-canonical DNA binding specificities of KAP6 and HMO1 and mechanistic insights into DNA bound and unbinding dynamics of KAP6. Int J Biol Macromol. 160: 925-933 (2020).


  1. Akila M, Rajakumara E, Qureshi A#. Ambient concentration of airborne microbes and endotoxins in rural households of southern India. Building and Environment, 179, 106970 (2020).


  1. Girdharv A, Bharathi V, Tiwari VR, Abhishek S Mahawar US, Raju G, Singh SK, Prabusankar G, Rajakumara E and Patel BK#. Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4. Int J Biol Macromol.147:117-130 (2020).


  1. Abhishek S, Sivadas S, Satish M, Deeksha W, Rajakumara E#. Dynamic Basis for Auranofin Drug Recognition by Thiol-Reductases of Human Pathogens and Intermediate Coordinated Adduct Formation with Catalytic Cysteine Residues. ACS Omega, 2019, 4, 9593-9602


  1. Abhishek S, Nivya MA, Nakarakanti NK, Deeksha W, Khosla S#, Rajakumara E#. Biochemical and dynamic basis for combinatorial recognition of H3R2K9me2 by dual domains of UHRF1. Biochimie, 149, 105-1142018 (2018).


  1. Satish M, Nivya MA, Abhishek S, Nakarakanti NK, Shivani D, M. Vani V, Rajakumara, E#. Computational characterization of substrate and product specificities, and functionality of SAM binding pocket in histone lysine methyltransferases from Arabidopsis, rice and maize. Proteins: Structure, Function, and Bioinformatics. 86(1):21-34 (2018).


  1. Rajakumara E#, Nakarakanti NK, Nivya MA and Satish, M. Mechanistic insights into the recognition of 5-methylcytosine oxidation derivatives by the SUVH5 SRA domain. Scientific Reports. 6: 2016 (2016).


  1. Devi S, Rajakumara E, Ahmed N#. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy. Scientific Reports. 5:15049 (2015).

From IFOM, MSKCC and CCMB

  1. Gonzalez-Huici, V., Szakal, B., Urulangodi, M., Psakhye, I., Castellucci, F., Menolfi, D., Rajakumara, E., Fumasoni, M., Bermejo, R., Jentsch, S., Branzei, D. DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity. EMBO j. 33(4):327-40 (2014)

  2. Rajakumara, E*., Wang, Z*., Ma, H., Hu, L., Chen, H., Lin, Y., Guo, R., Wu, F., Li, H., Lan, F., Shi, Y., Xu, Y., Patel, D.J and Shi, Y. PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression. Molecular Cell 43:275–284 (2011). (*Equal contribution). (Selected article in ‘Epigenetics and chromatin’ field by Molecular Cell).

  3. Rajakumara, E*., Law, J.A*., Simanshu, D.K., Voigt, P., Johnson, L.M., Reinberg, D., Patel, D.J and Jacobsen, S.E. A dual flip- out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes and Dev.25(2):137-52 (2011). (*Equal contribution). (Journal Cover Page; Evaluated by Faculty of 1000 Biology and Medicine)

  4. Arora, P*., Goyal, A*., Natarajan, V.T*., Rajakumara, E., Verma, P., Gupta, R., Yousuf, M., Trivedi, O.A., Mohanty, D., Tyagi, A., Sankaranarayanan, R and Gokhale, R.S. Nat Chem Biol. 5(3):166-73 (2009). (*Equal contribution)

  5. Rajakumara, E*., Acharya, P*., Ahmad, S., Sankaranaryanan, R and Rao, N.M. Biochim Biophys Acta. 1784(2):302-11 (2008). (*Equal contribution).

  6. Rajakumar, E., Aggarwal, R. and Singh, B. Acta Phytopathologica et Entomologica Hungarica, 40 (1-2), 35-42 (2005).

  7. Madhurantakam, C*., Rajakumara, E*., Mazumdar, P.A., Saha, B., Mitra, D., Wiker, H.D., Sankaranarayanan, R and Das, A.K. J. Bacteriol.187(6); 2175-81 (2005). (*Equal contribution).

  8. Acharya, P*., Rajakumara, E*., Sankaranarayanan, R. and Rao, N.M. J Mol Biol, 341(5); 1271-81 (2004). (*Equal contribution).

  9. Rajakumara, E., Acharya, P., Ahmad, S., Shanmugam, V.M., Rao, N.M. and Sankaranarayanan, R. Acta crystallogr. D60; 160- 162 (2004).