We employ multi-pronged biochemical, biophysical and computational approaches to unravel the mechanistic insights into functioning of biological macromolecules in epigenetic events and in topological modulation of DNA structures during replication and repair.
ITC study (biochemical) of binding of epigenetic regulator to modified DNA (N value of 0.5 indicates two molecules of protein bind single duplex DNA).
SUVH5SRA-fully hydroxyl methy CG
2:1 SUVH5- fully hydroxymethyl CG duplex DNA
(Structural study support the biochemical study)