Research
PUBLICATIONS AND RECENT GRANTS
K. Larripa and A. Radulescu. A Mathematical Model of Microglia Glucose Metabolism and Lactylation with Positive Feedback. Under Submission to Journal of Theoretical Biology (June 2024).
C. Ty, A. Case, E. Mezzulo, A. Penland, K. Larripa. An Agent-based Model of Microglia and Neuron Interaction: Implications in Neurodegenerative Disease. Under Submission (July 2024). (Includes undergraduate co-authors)
A. Castillo, J. Haddock, I. Hartsock, P. Hoyos, L. Kassab, A. Kryshchenko, K. Larripa, D. Needell, S. Suryanarayanan, K. Yacoubou-Djima. Randomized Iterative Methods for Tensor Regression Under the t-Product. Advances in Data Science. Springer, 2024. Under Submission.
National Science Foundation RUI: Mathematical Modeling of Microglia. $307,661. 2023-2026 (PI).
California Learning Lab Grand Challenge: Building Critical Mass in Data Science. $200,000. 2023-2025 (PI, with co-PI Bori Mazzag).
A.S. Frank, K. Larripa, H. Ryu, S. Roblitz. Macrophage phenotype transitions in a stochastic gene-regulatory network model. Journal of Theoretical Biology, 2023.
E. Camacho, A. Dobreva, K. Larripa, A. Radulescu, D. Schmidt, and I. Trejo. Analyzing a mathematical model for metabolic pathways in a single cone to gain insight into pathological mechanisms. Bioscience Reports, March 2022.
A. Dobreva, R. Brady, K. Larripa, C. Puelz, M. Olfusen. A physiological model of the inflammatory-thermal-pain-cardiovascular interactions during an endotoxin challenge. The Journal of Physiology, January 2021.
A.S. Frank, K. Larripa, H. Ryu, S. Roblitz, R.G. Snodgrass. Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization. Journal of Theoretical Biology, 2020.
E. Camacho, A. Dobreva, K. Larripa, A. Radulescu, D. Schmidt, and I. Trejo, Mathematical modeling of retinal degeneration. Accepted July 2020.
R. Everett, K. Flores, N. Henscheid, J. Lagergren, K. Larripa, D. Li, J. Nardini, P. Nguyen, E.B. Pitman, E.M. Rutter. A Tutorial Review of Mathematical Techniques for Quantifying Tumor Heterogeneity. Mathematical Biosciences and Engineering. Mathematical Biosciences and Engineering 17, no. 4 (2020): 3660.
J. Gallaher, K. Larripa, U. Ledzewicz, M. Renardy, B. Shtylla, N. Tania, D. White, K. Wood, L. Zhu, C. Passey, M. Robbins, N. Bezman, S. Shelat, H. J. Cho, H. Moore. Methods for determining key components in a mathematical model for tumor-immune dynamics in multiple myeloma. Journal of Theoretical Biology 458 31-46 (2018).
J. Gallaher, K. Larripa, U. Ledzewicz, M. Renardy, B. Shtylla, N. Tania, D. White, K. Wood, L. Zhu, C. Passey, M. Robbins, N. Bezman, S. Shelat, H. J. Cho, H. Moore. A mathematical model for tumor-immune dynamics in multiple myeloma. Understanding Complex Biological Systems with Mathematics. Springer, 89-122 (2018).
K. Larripa and B. Mazzag. Leveraging the Mathematical Contest in Modeling to Enhance the Undergraduate STEM Experience. Problems, Resources, and Issues in Mathematics Undergraduate Studies (2018).
K. Larripa and A. Gallegos. A mathematical model of Noggin and BMP densities in adult neural stem cells. Letters in Biomathematics. 4, 219-243 (2017).
R. Brady, C. Puelz, I. Ramirez, K. Larripa and M. Olufsen. A coupled model exploring the cardiovascular response to an acute inammation event. 5th Annual Conference on Computational and Mathematical Biomedical Engineering Proceedings (2017).
K. Larripa and B. Mazzag. A Modular Approach to Teaching Mathematical Modeling in Biotechnology in the Undergraduate Curriculum. Problems, Resources, and Issues in Mathematics Undergraduate Studies. 485-504, (2016).
B. Rubinstein, K. Larripa , P. Sommi and A. Mogilner. The elasticity of motor microtubule bundles and shape of the mitotic spindle. Physical Biology , 6(1), (2009).
K. Larripa and A. Mogilner. Transport of a 1D viscoelastic actin myosin strip of gel as a model of a crawling cell. Physic A. 372(1), 113-123 (2006).
RECENT CONFERENCES AND WORKSHOPS
Simons Laufer Mathematical Sciences Institute Summer Research in Mathematics (Data Driven Modeling of Epidemic Dynamics), 2024.
The Carpentries Instructor Training, 2024
American Institute of Mathematics (Column Slice Action Methods for Tensor Problems in Data Science), 2024.
American Institute of Mathematics at Caltech (Population Level Modeling of Tumor-Macrophage Dynamics), October 2023.
Institute of Pure and Applied Mathematics Research Collaboration Workshop "Women in Data Science and Mathematics." August 2023.
JMM Special Session: Understanding COVID-19-- Three Years of Mathematical Models to Address the Global Pandemic, January 2023 (co-organizer).
American Institute of Mathematics, August 2022.
Mathematical Sciences Research Institute Research in Mathematics Program, Fall 2021.
CSU STEM-NET Faculty Fellow 2021-2024.
JMM Special Session: Understanding COVID-19: Mathematical Models to Address the Global Pandemic, January 2021 (co-organizer).
Institute of Pure and Applied Mathematics: Mathematical Models in Understanding COVID-19, August 2020.
American Institute of Mathematics Structured Quartet Research Ensembles: A Mathematical Model of Macrophage Differentiation in the Tumor Microenvironment, 2020.
JMM Special Session: Utilizing Mathematical Models to Understand Tumor Heterogeneity and Drug Resistance, January 2020 (co-organizer).
Institute of Pure and Applied Math Collaborative Workshop in Mathematical Biology, June 2019.
JMM Special Session: Recent Advances in Mathematical Modeling of Cancer, January 2019 (co-organizer).
Banff International Research Station for Mathematical Innovation and Discovery (BIRS): Integrative Models for Cellular Disease, June 2018.
UC Irvine and National Institute of Health: Cancer Systems Biology Shortcourse, May 2018.
Oberwolfach: Math Modeling in Systems Biology, November 2017.
Math Biosciences Institute: Women Advancing Mathematical Biology: Understanding Complex Biological Systems with Mathematics, April 2017.
JMM Special Session in Physiology and Medicine 2017 (co-organizer).
AMS Math Research Community: Math in Physiology and Medicine, June 2016.
