半田寛

経歴

2017年 -群馬大学医学部血液内科学 診療科長 診療教授

2003年 -群馬大学大学院血液内科学講師

2002年- 群馬大学医学部保健学科応用検査学助手

2002年- Gunma University, Faculty of Medicine, School of Health Science

2001年 - 2002年群馬大学医学部附属病院血液内科

2001年 - 2002年Gunma University Hospital, Division of Hematology

1996年 - 1998年群馬大学医学部附属病院草津分院内科学講座 助手

1996年 - 1998年Gunma University Hospital, Kusatsu Branch Hospital

1993年 - 1996年Rush Presbyterian St Lukes Medical Center, Rush Cancer Institute at Chicago, USA

1993年 - 1996年Rush Presbyterian St Lukes Medical Center, Rush Cancer Institute at Chicago, USA

書籍 ：

• これ血液悪性疾患?自分の守備範囲? 非専門医のための見分け方
  医学書院 2010

• EBM血液疾患の治療2010-2011 形質細胞性白血病に対する治療は
  中外医学社 2010

• 造血器腫瘍治療 これは困ったぞどうしよう 2版 原発性マクログロブリン血症患者の意識が朦朧としてきた。血清IgM値が11g/dlある。さてどうしよう?
  中外医学社 2010

• 造血器腫瘍治療-これは困ったぞどうしよう!
  中外医学社 2009

• 造血器腫瘍治療-これは困ったぞどうしよう!
  中外医学社 2006

講演・口頭発表等：

• Mircro-RNA expression is associated with expression of DNA methyltransferases and anti-apoptotic gene mcl-1 in multiple myeloma and monoclonal gammopathy with undetermined significance (MGUS)
  (European Hematology Association (EHA) 2012)

• Association between micro-RNA and epigenetic modifiers DNA methyltransferases (DNMTs), histone deacetylases (HDACs) in multiple myeloma (MM) and monoclonal gammmopathy with undetermined significance (MGUS)
  (American Society of Hematology 2012)

• Mircro-RNA expression is associated with expression of DNA methyltransferases and anti-apoptotic gene mcl-1 in multiple myeloma and monoclonal gammopathy with undetermined significance (MGUS)
  (European Hematology Association (EHA) 2012)

• Association between micro-RNA and epigenetic modifiers DNA methyltransferases (DNMTs), histone deacetylases (HDACs) in multiple myeloma (MM) and monoclonal gammmopathy with undetermined significance (MGUS)
  (American Society of Hematology 2012)

• Human telomerase reverse transcriptase (hTERT) expression detected by flow cytometry in CD34 positive progenitor fraction in myelodysplasitc syndorme and acute myeloid leukemia
  (15th Congress of the European Hematology Association 2010)

論文等

• Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma.
  Nobuhiko Kobayashi, Tsukasa Oda, Makiko Takizawa, Takuma Ishizaki, Norifumi Tsukamoto, Akihiko Yokohama, Hisashi Takei, Takayuki Saitoh, Hiroaki Shimizu, Kazuki Honma, Kei Kimura-Masuda, Yuko Kuroda, Rei Ishihara, Yuki Murakami, Hirokazu Murakami, Hiroshi Handa
  Cancers 12(2) 2020年2月5日 査読有り

• PDCD1 and PDCD1LG1 polymorphisms affect the susceptibility to multiple myeloma.
  Tetsuhiro Kasamatsu, Maaya Awata, Rei Ishihara, Yuki Murakami, Nanami Gotoh, Morio Matsumoto, Morio Sawamura, Akihiko Yokohama, Hiroshi Handa, Norifumi Tsukamoto, Takayuki Saitoh, Hirokazu Murakami
  Clinical and experimental medicine 20(1) 51-62 2020年2月 査読有り

• PARP1 V762A polymorphism affects the prognosis of myelodysplastic syndromes.
  Nanami Gotoh, Yusuke Minato, Takayuki Saitoh, Noriyuki Takahashi, Tetsuhiro Kasamatsu, Kana Souma, Tsukasa Oda, Takumi Hoshino, Toru Sakura, Takuma Ishizaki, Hiroaki Shimizu, Makiko Takizawa, Akihiko Yokohama, Norifumi Tsukamoto, Hiroshi Handa, Hirokazu Murakami
  European journal of haematology 2020年1月31日 査読有り

• IgG4-related Disease with a Cardiac Mass.
  Ikuko Matsumura, Takeki Mitsui, Kenichi Tahara, Hiroaki Shimizu, Kunio Yanagisawa, Takuma Ishizaki, Hiromi Koiso, Makiko Takizawa, Akihiko Yokohama, Takayuki Saitoh, Junko Hirato, Hirokazu Murakami, Hiroshi Handa, Norifumi Tsukamoto
  Internal medicine (Tokyo, Japan) 2020年1月17日 査読有り

• RUNX1 mutation in a patient with myelodysplastic syndrome and decreased erythrocyte expression of blood group A antigen
  Hayakawa A, Sano R, Takahashi Y, Kubo R, Harada M, Omata M, Yokohama A, Handa H, Tsukada J, Takeshita H, Tsuneyama H, Ogasawara K, Kominato Y
  Transfusion 60 184-196 2020年1月 査読有り

• Elotuzumab plus lenalidomide and dexamethasone for newly diagnosed multiple myeloma: a randomized, open-label, phase 2 study in Japan.
  Kohmei Kubo, Mitsuo Hori, Kensuke Ohta, Hiroshi Handa, Kiyohiko Hatake, Morio Matsumoto, Shotaro Hagiwara, Kazuteru Ohashi, Chiaki Nakaseko, Kenshi Suzuki, Shigeki Ito, Gen Kinoshita, Suresh G Shelat, Masafumi Miyoshi, Naoki Takezako
  International journal of hematology 111(1) 65-74 2020年1月 査読有り

• SLAMF3-mediated signaling via ERK pathway activation promotes aggressive phenotypic behaviors in multiple myeloma
  Ishibashi M, Takahashi R, Tsubota A, Sasaki M, Handa H, Imai Y, Tanaka N, Tsukune Y, Tanosaki S, Ito S, Asayama T, Sunakawa M, Kaito Y, Kuribayashi-Hamada Y, Kondo-Onodera A, Moriya K, Komatsu N, Tanaka J, Odajima T, Sugimori H, Inokuchi K, Tamura H
  Molecular Cancer Research 2020年1月 査読有り

• Successful Management of Acquired Factor V Inhibitor by Monitoring Factor V Activity, Antigen, and Inhibitor Values during Immunosuppressive Therapy.
  Mihara M, Ogawa Y, Nagasaka M, Kobayashi N, Shimizu H, Shinozawa K, Fukutake K, Inoue M, Murakami M, Handa H
  Acta haematologica 1-5 2019年9月 査読有り

• Evaluation of the Revised International Staging System (R-ISS) in Japanese patients with multiple myeloma.
  Ozaki S, Handa H, Saitoh T, Murakami H, Itagaki M, Asaoku H, Suzuki K, Isoda A, Matsumoto M, Sawamura M, Sunami K, Takezako N, Hagiwara S, Kuroda Y, Chou T, Nagura E, Shimizu K
  Ann Hematol. 98(7) 2019年7月 査読有り

• Activin A: a novel urinary biomarker of renal impairment in multiple myeloma.
  Iriuchishima H, Maeshima A, Takahashi S, Ishizaki T, Yokohama A, Tsukamoto N, Saitoh T, Murakami H, Handa H
  Biosci Rep. 39(5) 2019年5月 査読有り

• Thalidomide maintenance therapy in Japanese myeloma patients: a multicenter, phase II clinical trial (COMET study).
  Hirokazu Murakami, Tetsuhiro Kasamatsu, Jun Murakami, Toru Kiguchi, Takeshi Kanematsu, Daisuke Ogawa, Hiroyuki Takamatsu, Hiroshi Handa, Shuji Ozaki, Hirokazu Miki, Takeshi Takahashi, Takaaki Takeo, Tatsuya Yamauchi, Takanobu Morishita, Hiroshi Kosugi, Kazuyuki Shimizu
  International journal of hematology 109(4) 409-417 2019年4月 査読有り

• Human telomerase reverse transcriptase expression in a CD34-positive hematopoietic progenitor of myelodysplastic syndrome and acute myelogenous leukemia.
  Handa H, Nishimoto N, Inoue M, Yokohama A, Tsukamoto N, Saitoh T, Murakami H
  Hematol Oncol. 2019年4月 査読有り

• 分娩を契機に甲状腺クリーゼと溶血の悪化を認めた自己免疫性溶血性貧血
  杉崎 真人, 石埼 卓馬, 入内島 裕乃, 清水 啓明, 柳沢 邦雄, 小川 孔幸, 横濱 章彦, 斉藤 貴之, 塚本 憲史, 半田 寛
  2019 年 60 巻 8 号 p. 924-928 60(8) 2019年4月 査読有り

• Prognostic impact of trisomy 21 in follicular lymphoma.
  Takeki Mitsui, Akihiko Yokohama, Hiromi Koiso, Akio Saito, Kohtaro Toyama, Hiroaki Shimizu, Takuma Ishizaki, Hiroyuki Irisawa, Makiko Takizawa, Takayuki Saitoh, Kayoko Murayama, Morio Matsumoto, Hiroshi Handa, Junko Hirato, Masaru Kojima, Hirokazu Murakami, Norifumi Tsukamoto
  British journal of haematology 184(4) 570-577 2019年2月 査読有り

• Malignancy-Associated Hypercalcemia Related with Receptor Activator of NF-κB Ligand (RANKL) Expression in T-Cell Acute Lymphoblastic Leukemia.
  Tahara K, Koiso H, Osaki YH, Sekigami T, Yokohama A, Saitoh T, Tsukamoto N, Murakami H, Abe M, Handa H
  Acta Haematol. 141(3) 2019年2月 査読有り

• 初回寛解から4年後に再燃した後天性凝固第V因子インヒビター
  明石直樹, 小川孔幸, 小川孔幸, 柳澤邦雄, 大崎洋平, 清水啓明, 石埼卓馬, 井上まどか, 村上正巳, 惣宇利正善, 惣宇利正善, 一瀬白帝, 一瀬白帝, 半田寛
  臨床血液 60(1) 46‐50(J‐STAGE) 2019年1月30日

• Safety of lenalidomide, dexamethasone, and cyclophosphamide in elderly Japanese patients with relapsed and refractory multiple myeloma: results of phase 1 study.
  Tsukune Y, Sasaki M, Isoda A, Ando J, Koike M, Matsumoto M, Sawamura M, Tamura H, Handa H, Imai Y, Yahata Y, Komatsu N
  International Journal of Myeloma 9 1-6 2019年 査読有り

• [Thyroid storm and exacerbation of autoimmune hemolytic anemia following childbirth].
  Manato Sugisaki, Takuma Ishizaki, Hirono Iriuchishima, Hiroaki Shimizu, Kunio Yanagisawa, Yoshiyuki Ogawa, Akihiko Yokohama, Takayuki Saitoh, Norifumi Tsukamoto, Hiroshi Handa
  [Rinsho ketsueki] The Japanese journal of clinical hematology 60(8) 924-928 2019年 査読有り

• Tumor long-axis diameter and SUVmax predict long-term responders in 90Y-ibritumomab tiuxetan monotherapy.
  Norifumi Tsukamoto, Akihiko Yokohama, Tetsuya Higuchi, Takeki Mitsui, Hiromi Koiso, Makiko Takizawa, Hiroaki Shimizu, Takuma Ishizaki, Morio Matsumoto, Kohtaro Toyama, Tohru Sakura, Hidemi Ogura, Takayuki Saitoh, Fumihiro Ishida, Hirokazu Murakami, Yoshito Tsushima, Hiroshi Handa
  International journal of hematology 109(1) 91-97 2019年1月 査読有り

• A novel CYCS mutation in the α-helix of the CYCS C-terminal domain causes non-syndromic thrombocytopenia.
  Uchiyama Y, Yanagisawa K, Kunishima S, Shiina M, Ogawa Y, Nakashima M, Hirato J, Imagawa E, Fujita A, Hamanaka K, Miyatake S, Mitsuhashi S, Takata A, Miyake N, Ogata K, Handa H, Matsumoto N, Mizuguchi T
  Clinical genetics 94(6) 548-553 2018年12月