Our area of research

Welcome to the Neuro-Glia Lab, dedicated to advancing the understanding of Alzheimer's disease (AD) and developing potential therapeutic strategies. Our lab focuses on investigating the intricate mechanisms underlying AD pathology, with a particular emphasis on neuronal and microglial cell culture-based assays, as well as neurobehavioral tests conducted on AD mouse models. By employing a multidisciplinary approach, we aim to unravel the complex interactions between different cell types in the brain and identify novel targets for intervention.

At our lab, we recognize the significance of neuronal cells, which are the primary players in AD pathogenesis. We employ state-of-the-art techniques to culture and manipulate neuronal cells in order to study the molecular and cellular changes associated with AD. These studies allow us to delve into the intricate signaling pathways, protein misfolding, synaptic dysfunction, and neuroinflammation observed in AD. By understanding the underlying mechanisms, we strive to develop interventions that can effectively counteract these processes and potentially slow down or prevent the progression of AD.

In addition to investigating neuronal cells, we recognize the critical role of microglia, the brain's resident macrophages, in AD. Microglia play a dual role in AD pathology, both as defenders against harmful insults and as contributors to neuroinflammation. Our lab employs advanced techniques to culture and study microglial cells, allowing us to investigate their activation, phenotypic changes, and interactions with neuronal cells. By elucidating the complex interplay between microglia and neurons, we aim to identify novel therapeutic targets that can modulate the neuroinflammatory response and promote neuroprotection in AD. In parallel with our in vitro assays, we utilize AD mouse model to evaluate the therapeutic potential of novel interventions. We employ a range of neurobehavioral tests that assess learning, memory, and motor functions, enabling us to evaluate the efficacy of interventions and their potential for translation to human AD patients.

Through our research efforts, we strive to make a meaningful impact on the lives of individuals affected by this devastating disease and work towards a future free from Alzheimer's. 

Research Projects

• Rewiring of Circadian Clock by Sulforaphane: Strategic Activation of Nrf2 Attenuates Sleep Deprivation Induced Alzheimer's Like Cognitive Dysfunctions in Mice.

• Strategic induction of microglial cells to develop early biomarkers and novel molecular targets for Alzheimer's disease – A secretome analysis.

• Sulforaphane mediated activation of protein degradation machinery: A strategic approach against the pathogenesis of Alzheimer's disease.

• Understanding the molecular dynamics of microglial movements under normal and stress conditions.