2018
Hypoxic stress upregulates the expression of Slc38a1 in brown adipocytes via hypoxia-inducible factor-1α.
Horie T., Fukasawa K., Iezaki T., Park G., Onishi Y., Ozaki K., Kanayama T., Hiraiwa M., Kitaguchi Y., Kaneda K., and Hinoi E#.
Pharmacology 101(1-2):64-71. 2018.
DOI: 10.1159/000480405
Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity.
Ikegami R., Shimizu I., Sato T., Yoshida Y., Hayashi Y., Suda M., Katsuumi G., Li J., Wakasugi T., Minokoshi Y., Okamoto S., Hinoi E., Nielsen S., Jespersen N.Z., Scheele C., Soga T., and Minamino T.
Cell Rep. 24(11):2827-2837.e5. 2018.
Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.
Iezaki T., Horie T., Fukasawa K., Kitabatake M., Nakamura Y., Park G., Onishi Y., Ozaki K., Kanayama T., Hiraiwa M., Kitaguchi Y., Kaneda K., Manabe T., Ishigaki Y., Ohno M., and Hinoi E#.
Stem Cell Reports 11(1):228-241. 2018.
The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis.
Iezaki T., Fukasawa K., Horie T., Park G., Robinson S., Nakaya M., Fujita H., Onishi Y., Ozaki K., Kanayama T., Hiraiwa M., Kitaguchi Y., Kaneda K., Yoneda Y., Takarada T., Guo X.E., Kurose H., and Hinoi E#.
Development 145(14):dev164004. 2018.
DOI: 10.1242/dev.164004
Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory.
Zhang T., Deyama S., Domoto M., Wada S., Yanagida J., Sasase H., Hinoi E., Nishitani N., Nagayasu K., Kaneko S., and Kaneda K.
Biol. Pharm. Bull. 41(7):1084-1088. 2018.
The synthetic cannabinoid 5F-AMB changes the balance between excitation and inhibition of layer V pyramidal neurons in the mouse medial prefrontal cortex.
Domoto M., Sasase H., Wada S., Ito S., Deyama S., Hinoi E., Kaneko S., and Kaneda K.
Psychopharmacology 235:2367-2376. 2018.
Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice.
Ito Y., Fukui M., Kanda M., Morishita K., Shoji Y., Kitao T., Hinoi E., and Shirahase H.
J. Pharmacol. Sci. 137(1):38-46. 2018.
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
Korogi W., Yoshizawa T., Karim M.F., Tanoue H., Yugami M., Sobuz S.U., Hinoi E., Sato Y., Oike Y., Mizuta H., and Yamagata K.
Biochem. Biophys. Res. Commun. 496(3):891-897. 2018.
2017
Amelioration of the Development of Osteoarthritis by Daily Intake of β-Cryptoxanthin.
Park G., Horie T., Fukasawa K., Ozaki K., Onishi Y., Kanayama T., Iezaki T., Kaneda K., Sugiura M., and Hinoi E#.
Biol. Pharm. Bull. 40(7):1116-1120. 2017.
Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain.
Park G., Horie T., Iezaki T., Okamoto M., Fukasawa K., Kanayama T., Ozaki K., Onishi Y., Sugiura M., and Hinoi E#.
Biosci. Biotechnol. Biochem. 81(5):1014-1017. 2017.
The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes.
Park G., Horie T., Kanayama T., Fukasawa K., Iezaki T., Onishi Y., Ozaki K., Nakamura Y., Yoneda Y., Takarada T., and Hinoi E#.
FEBS J. 284(5):784-795. 2017.
DOI: 10.1111/febs.14019
Bone resorption is regulated by circadian clock in osteoblasts.
Takarada T., Xu C., Ochi H., Nakazato R., Yamada D., Nakamura S., Kodama A., Shimba S., Mieda M., Fukasawa K., Ozaki K., Iezaki T., Fujikawa K., Yoneda Y., Numano R., Hida A., Tei H., Takeda S., and Hinoi E#.
J. Bone Miner. Res. 32(4):872-881. 2017.
DOI: 10.1002/jbmr.3053
The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.
Onishi Y., Park G., Iezaki T., Horie T., Kanayama T., Fukasawa K., Ozaki K., and Hinoi E#.
Biochem. Biophys. Res. Commun. 482(2):329-334. 2017.
Disruption of Bmal1 Impairs Blood-Brain Barrier Integrity via Pericyte Dysfunction.
Nakazato R., Kawabe K., Yamada D., Ikeno S., Mieda M., Shimba S., Hinoi E., Yoneda Y., and Takarada T.
J. Neurosci. 37(42):10052-10062. 2017.
The intrinsic microgrial clock system regulates interleukin-6 expression.
Nakazato R., Hotta S., Yamada D., Kou M., Nakamura S., Takahata Y., Tei H., Numano R., Hida A., Shimba S., Mieda M., Hinoi E., Yoneda Y., and Takarada T.
Glia 65(1):198-208. 2017
DOI: 10.1002/glia.23
2016
ATF3 controls proliferation of osteoclast precursor and bone remodeling.
Fukasawa K., Park G., Iezaki T., Horie T., Kanayama T., Ozaki K., Onishi Y., Takahata Y., Yoneda Y., Takarada T., Kitajima S., Vacher J., and Hinoi E#.
Sci. Rep. 6(1):30918. 2016.
Transcriptional modulator Ifrd1 regulates osteoclast differentiation through enhancing NF-κB/NFATc1 pathway.
Iezaki T., Fukasawa K., Park G., Horie T., Kanayama T., Ozaki K., Onishi Y., Takahata Y., Nakamura Y., Takarada T., Yoneda Y., Nakamura T., Vacher J., and Hinoi E#.
Mol. Cell. Biol. 36(19):2451-2463. 2016.
DOI: 10.1128/MCB.01075-15
ATF3 deficiency in chondrocytes alleviates osteoarthritis development.
Iezaki T., Ozaki K., Fukasawa K., Inoue M., Kitajima S., Muneta T., Takeda S., Fujita H., Onishi Y., Horie T., Yoneda Y., Takarada T., and Hinoi E#.
J. Pathol. 239(4):426-437. 2016.
DOI: 10.1002/path.4739
Protective upregulation of activating transcription factor-3 against glutamate neurotoxicity in neuronal cells under ischemia.
Takarada T., Kou M., Hida M., Fukumori R., Nakamura S., Kutsukake T., Kuramoto N., Hinoi E., and Yoneda Y.
J. Neurosci. Res. 94(5):378-388. 2016.
DOI: 10.1002/jnr.23723
Circadian Clock Regulates Bone Resorption in Mice.
Xu C., Ochi H., Fukuda T., Sato S., Sunamura S., Takarada T., Hinoi E., Okawa A., and Takeda S.
J. Bone Miner. Res. 31(7):1344-1355. 2016.
DOI: 10.1002/jbmr.2803
Genetic analysis of Runx2 function during intramembranous ossification.
Takarada T., Nakazato R., Tsuchikane A., Fujikawa K., Iezaki T., Yoneda Y., and Hinoi E#.
Development 143(2):211-218. 2016.
DOI: 10.1242/dev.128793
GDF1 is a novel mediator of macrophage infiltration in brown adipose tissue of obese mice.
Onishi Y., Fukasawa K., Ozaki K., Iezaki T., Yoneda Y., and Hinoi E#.
Biochem. Biophys. Rep. 5:216-223. 2016.
Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro.
Takarada T., Nakamichi N., Nakazato R., Kakuda T., Kokubo H., Ikeno S., Nakamura S., Kuramoto N., Hinoi E., and Yoneda Y.
Biochem. Biophys. Rep. 5:89-95. 2016.
The transcriptional modulator interferon-related developmental regulator 1 in osteoblasts suppresses bone formation and promotes bone resorption.
Iezaki T., Onishi Y., Ozaki K., Fukasawa K., Takahata Y., Nakamura Y., Fujikawa K., Takarada T., Yoneda Y., Yamashita Y., Shioi G., and Hinoi E#.
J. Bone Miner. Res. 31(3):573-584. 2016.
DOI: 10.1002/jbmr.2720
Upregulation of Slc38a1 gene along with promotion of neurosphere growth and subsequent neuronal specification in undifferentiated neural progenitor cells exposed to theanine.
Takarada T., Ogura M., Nakamichi N., Kakuda T., Nakazato R., Kokubo H., Ikeno S., Nakamura S., Kutsukake T., Hinoi E., and Yoneda Y.
Neurochem. Res. 41:5-15. 2016.
2015
Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice.
Ozaki K., Okamoto M., Fukasawa K., Iezaki T., Onishi Y., Yoneda Y., Sugiura M., and Hinoi E#.
J. Pharmacol. Sci. 129(1):72-77. 2015.
Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.
Wei J., Shimazu J., Makinistoglu MP., Maurizi A., Kajimura D., Zong H., Takarada T., Iezaki T., Pessin JE., Hinoi E., and Karsenty G.
Cell 161(7):1576-1591. 2015.
Upregulation of Runt-Related Transcription Factor-2 through CCAAT Enhancer Binding Protein-Beta Signaling Pathway in Microglial BV-2 Cells Exposed to ATP.
Nakazato R., Takarada T., Ikeno S., Nakamura S., Kutsukake T., Hinoi E., and Yoneda Y.
J. Cell. Physiol. 230(10):2510-2521. 2015.
DOI: 10.1002/jcp.24988
Involvement of calpain in 4-hydroxynonenal-induced disruption of gap junction-mediated intercellular communication among fibrocytes in primary cultures derived from the cochlear spiral ligament.
Yamaguchi T., Yoneyama M., Hinoi E., and Ogita K.
J. Pharmacol. Sci. 129(2):127-134. 2015.
Daily oral intake of theanine prevents the decline of 5-bromo-2'-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress.
Takarada T., Nakamichi N., Kakuda T., Nakazato R., Kokubo H., Ikeno S., Nakamura S., Hinoi E., and Yoneda Y.
J. Pharmacol. Sci. 127(3):292-297. 2015.
2014
Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure.
Hinoi E., Nakamura Y., Takada S., Fujita H., Iezaki T., Hashizume S., Takahashi S., Odaka Y., Watanabe T., and Yoneda Y.
Diabetes 63(1):162-175. 2014.
DOI: 10.2337/db13-0808
Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.
Hinoi E., Iezaki T., Ozaki K., and Yoneda Y.
Biochem. Biophys. Res. Commun. 452:974-979. 2014.
PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.
Hinoi E., Iezaki T., Fujita H., Watanabe T., Odaka Y., Ozaki K., and Yoneda Y.
Biochem. Biophys. Res. Commun. 450(1):255-260. 2014.
Constitutive and functional expression of runt-related transcription factor-2 by microglial cells.
Nakazato R., Takarada T., Watanabe T., Nguyen BT., Ikeno S., Hinoi E., and Yoneda, Y.
Neurochem. Int. 74:24-35. 2014.
Insulin sensitization by a novel partial peroxisome proliferator-activated receptor γ agonist with protein tyrosine phosphatase 1B inhibitory activity in experimental osteoporotic rats.
Kubo M., Fukui M., Ito Y., Kitao T., Shirahase H., Hinoi E., and Yoneda Y.
J. Pharmacol. Sci. 124(2):276-285. 2014.
DOI: 10.1254/jphs.13236fp
Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons.
Fukumori R., Takarada T., Nakazato R., Fujikawa K., Kou M., Hinoi E., and Yoneda Y.
PLoS One 8(7):e69718. 2013.
A negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells.
Le NQ., Binh NT., Takarada T., Takarada-Iemata M., Hinoi E., and Yoneda Y.
J. Pharmacol. Sci. 122(4):318-325. 2013.
DOI: 10.1254/jphs.13091fp
Myosin VI reduces proliferation, but not differentiation, in pluripotent P19 cells.
Takarada T., Kou M., Nakamichi N., Ogura M., Ito Y., Fukumori R., Kokubo H., Acosta GB., Hinoi E., and Yoneda Y.
PLoS One 8(5):e63947. (2013)
An analysis of skeletal development in osteoblast- and chondrocyte-specific Runx2 knockout mice.
Takarada T., Hinoi E., Nakazato R., Ochi H., Xu C., Tsuchikane A., Takeda S., Karsenty G., Abe T., Kiyonari H., and Yoneda Y.
J. Bone Miner. Res. 28(10):2064-2069. (2013)
DOI: 10.1002/jbmr.1945
Repression of adipogenesis through promotion of Wnt/ß-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia.
Nakamura Y*., Hinoi E*., Iezaki T., Takada S., Hashizume S., Takahata Y., Tsuruta E., Takahashi S., and Yoneda Y.
Biochim. Biophys. Acta. Mol. Basis Dis. 1832(8):1117-1128. 2013.
Prevention of bone loss after ovariectomy in mice with preferential overexpression of the transcription factor paired box-5 in osteoblasts.
Fujita H*., Hinoi E*., Watanabe T., Iezaki T., Takamori M., Ogawa S., and Yoneda Y.
Biol. Pharm. Bull. 36(3):481-484. 2013.
In vivo and in vitro treatment with edaravone promotes proliferation of neural progenitor cells generated following neuronal loss in the mouse dentate gyrus.
Kikuta M., Shiba T., Yoneyama M., Kawada K., Yamaguchi T., Hinoi E., Yoneda Y., and Ogita K.
J. Pharmacol. Sci. 121(1):74-83. 2013.
DOI: 10.1254/jphs.12162fp
2012
Promotion of both proliferation and neuronal differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter slc38a1.
Ogura M., Kakuda T., Takarada T., Nakamichi N., Fukumori R., Kim YH., Hinoi E., and Yoneda Y.
PLoS One 7(10):e48270. 2012.
Clock genes influence gene expression in growth plate and endochondral ossification in mice.
Takarada T., Kodama A., Hotta S., Mieda M., Shimba S., Hinoi E., and Yoneda Y.
J. Biol. Chem. 287(43):36081-36095. 2012.
Positive regulation by GABAB receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4.
Takahata Y*., Hinoi E*., Takarada T., Nakamura Y., Ogawa S., and Yoneda Y.
J. Biol. Chem. 287(40):33293-33303. (2012)
The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osterix and Osteocalcin.
Hinoi E., Nakatani E., Yamamoto T., Iezaki T., Takahata Y., Fujita H., Ishiura R., Takamori M., and Yoneda Y.
J. Bone Miner. Res. 27(12):2526-2534. (2012)
DOI: 10.1002/jbmr.1708
Possible modulation of process extension by N-methyl-D-aspartate receptor expressed in osteocytic MLO-Y4 cells.
Fujita H*., Hinoi E*., Nakatani E., Yamamoto T., Takarada T., and Yoneda Y.
J. Pharmacol. Sci. 119(1):112-116. 2012.
DOI: 10.1254/jphs.12068sc
Amelioration by the natural polyamine, spermine, of cartilage and bone destruction in rats with collagen-induced arthritis.
Iezaki T*., Hinoi E*., Yamamoto T., Ishiura R., Ogawa S., and Yoneda Y.
J. Pharmacol. Sci. 119(1):107-111. 2012.
DOI: 10.1254/jphs.11241sc
Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts.
Takarada T., Takarada-Iemata M., Takahata Y., Yamada D., Yamamoto T., Nakamura Y., Hinoi E., and Yoneda Y.
J. Cell. Physiol. 227(10):3477-3487. 2012.
DOI: 10.1002/jcp.24048
Positive regulation of osteoclastic differentiation by growth differentiation factor-15 up-regulated in osteocytic cells under hypoxia.
Hinoi E., Ochi H., Takarada T., Nakatani E., Iezaki T., Nakajima H., Fujita H., Takahata Y., Hidano S., Kobayashi T., Takeda S., and Yoneda Y.
J. Bone Miner. Res. 27(4):938-949. 2012.
DOI: 10.1002/jbmr.1538
The natural polyamines spermidine and spermine prevent bone loss through preferential disturbance of osteoclastic activation in ovariectomized mice.
Yamamoto T*., Hinoi E*., Fujita H., Iezaki T., Takahata Y., Takamori M., and Yoneda Y.
Br. J. Pharmacol. 166(3):1084-1096. 2012.
2011
Osteoblastic GABAB receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor-kB ligand in mouse bone.
Takahata Y., Takarada T., Hinoi E., Nakamura Y., Fujita H., and Yoneda Y.
J. Biol. Chem. 286(38):32906-32917. 2011.
Selective upregulation of Per1 mRNA expression by ATP through activation of P2X7 purinergic receptors expressed in microglial cells.
Nakazato R., Takarada T., Yamamoto T., Hotta S., Hinoi E., and Yoneda Y.
J. Pharmacol. Sci. 116(4):350-361. 2011.
DOI: 10.1254/jphs.11069fp
Positive regulation by GABABR1 subunit of leptin expression through gene transactivation in adipocytes.
Nakamura Y*., Hinoi E*., Takarada T., Takahata Y., Yamamoto T., Fujita H., Takada S., Hashizume S., and Yoneda Y.
PLoS One 6(5):e20167. 2011.
Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual.
Kajimura D., Hinoi E., Ferron M., Kode A., Riley JK., Zhou B., Guo XE., and Karsenty G.
J. Exp. Med. 208(4):841-851. 2011.
DOI: 10.1084/jem.20102608
A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-D-aspartate receptors in cultured rat hippocampal neurons.
Kambe Y., Nakamichi N., Takarada T., Fukumori R., Nakazato R., Hinoi E., and Yoneda Y.
Neurochem. Int. 59(1):10-20. 2011.
Negative regulation of osteoblastogenesis through downregulation of runt-related transcription factor-2 in osteoblastic MC3T3-E1 cells with stable overexpression of the cystine/glutamate antiporter xCT subunit.
Uno K., Takarada T., Takarada-Iemata M., Nakamura Y., Fujita H., Hinoi E., and Yoneda Y.
J. Cell. Physiol. 226(11):2953-2964. 2011.
DOI: 10.1002/jcp.22642
A negative correlation between expression profiles of runt-related transcription factor-2 and cystine/glutamate antiporter xCT subunit in ovariectomized mouse bone.
Uno K., Takarada T., Nakamura Y., Fujita H., Hinoi E., and Yoneda Y.
J. Pharmacol. Sci. 115(3):309-319. 2011.
DOI: 10.1254/jphs.10310fp
Possible involvement of glutamatergic signaling machineries in pathophysiology of rheumatoid arthritis.
Hinoi E., and Yoneda Y.
J. Pharmacol. Sci. 116(3):248-256. 2011.
DOI: 10.1254/jphs.11r03cr
2009
An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion.
Hinoi E., Gao N., Jung DY., Yadav V., Yoshizawa T., Kajimura D., Myers MG Jr., Chua SC Jr., Wang Q., Kim JK., Kaestner KH., and Karsenty G.
Ann. NY Acad. Sci. 1173:E20-E30. 2009.
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts.
Yoshizawa T*., Hinoi E*., Jung DY., Kajimura D., Ferron M., Seo J., Graff JM., Kim JK., and Karsenty G.
J. Clin. Invest. 119(9):2807-2817. 2009.
DOI: 10.1172/JCI39366
Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.
Takarada T., Takahata Y., Iemata M., Hinoi E., Uno K., Hirai T., Yamamoto T., and Yoneda Y.
J. Cell. Physiol. 220(3):756-764. 2009.
DOI: 10.1002/jcp.21821
Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members.
Takarada T., Hojo H., Iemata M., Sahara K., Kodama A., Nakamura N., Hinoi E., and Yoneda Y.
Bone 45(3):568-578. 2009.
Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes.
Nakamura Y., Takarada T., Kodama A., Hinoi E., and Yoneda Y.
J. Pharmacol. Sci. 109(3):413-423. 2009.
DOI: 10.1254/jphs.08315fp
2008
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity.
Hinoi E., Gao N., Jung DY., Yadav V., Yoshizawa T., Myers MG Jr., Chua SC Jr., Kim JK., Kaestner KH., and Karsenty G.
J. Cell Biol. 183(7):1235-1242. 2008.
Differential regulation of cellular maturation in chondrocytes and osteoblasts by glycine.
Takahata Y., Takarada T., Osawa M., Hinoi E., Nakamura Y., and Yoneda Y.
Cell Tissue Res. 333:91-103. 2008.
Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice.
Ferron M., Hinoi E., Karsenty G., and Ducy P.
Proc. Natl. Acad. Sci. USA. 105(13):5266-5270. 2008.
Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain.
Kakuda T*., Hinoi E*., Abe A., Nozawa A., Ogura M., and Yoneda Y.
J. Neurosci. Res. 86(8):1846-1856. 2008.
DOI: 10.1002/jnr.21637
Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner.
Takarada T., Hinoi E., Takahata Y., and Yoneda Y.
J. Cell. Physiol. 215(2):320-328. 2008.
DOI: 10.1002/jcp.21310
2007
Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid.
Takarada T., Hinoi E., Kambe Y., Sahara K., Kurokawa S., Takahata Y., and Yoneda Y.
Eur. J. Pharmacol. 575(1-3):1-11. 2007.
Endocrine Regulation of energy metabolism by the skeleton.
Lee NK., Sowa H., Hinoi E., Ferron M., Ahn JD., Confavreux C., Dacquin R., Mee PJ., McKee M., Jung DY., Zhang Z., Kim JK., Mauvais-Jarvis F., Ducy P., and Karsenty G.
Cell 130(3):456-469. 2007. F1000Primeに選出
Suppression by glutamate of proliferative activity through glutathione depletion mediated by the cystine/glutamate antiporter in mesenchymal C3H10T1/2 stem cells.
Iemata M., Takarada T., Hinoi E., Taniura H., and Yoneda, Y.
J. Cell. Physiol. 213(3):721-729. 2007.
DOI: 10.1002/jcp.21145
Glutamate is a determinant of cellular proliferation through modulation of nuclear factor E2 p45-related factor-2 expression in osteoblastic MC3T3-E1 cells.
Uno K., Takarada T., Hinoi E., and Yoneda Y.
J. Cell. Physiol. 213(1):105-114. 2007.
DOI: 10.1002/jcp.21095
Glutamate suppresses osteoclastogenesis through the cystine/glutamate antiporter.
Hinoi E., Takarada T., Uno K., Inoue M., Murafuji Y., and Yoneda Y.
Am. J. Pathol. 170(4):1277-1290. 2007.
Oral administration of phenolic antidiarrheic ingredients prevents ovariectomy-induced bone loss.
Moriguchi N*., Hinoi E*., Takarada T., Matsushima N., Uno K., and Yoneda Y.
Biochem. Pharmacol. 73(3):385-393. 2007.
Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis.
Hinoi E., Takarada T., Fujimori S., Wang L., Iemata M., Uno K., and Yoneda Y.
Bone 40(2):337-344. 2007.
2006
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium.
Hinoi E., Bialek P., Chen YT., Rached MT., Groner Y., Behringer RR., Ornitz DM., and Karsenty G.
Genes Dev. 20(21):2937-2942. 2006. F1000Primeに選出
DOI: 10.1101/gad.1482906
Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts.
Fujimori S., Hinoi E., Takarada T., Iemata M., Takahata Y., and Yoneda Y.
Eur. J. Pharmacol. 550(1-3):24-32. 2006.
Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter.
Wang L*., Hinoi E*., Takemori A., Nakamichi N., and Yoneda Y.
J. Biol. Chem. 281(34):24553-24565. 2006.
Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes.
Hinoi E., Ueshima T., Hojo H., Iemata M., Takarada T., and Yoneda Y.
J. Biol. Chem. 281(33):23632-23642. 2006.
A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts.
Hinoi E., Takarada T., Tsuchihashi Y., Fujimori S., Moriguchi N., Wang L., Uno K., and Yoneda Y.
Mol. Pharmacol. 70(3):925-935. 2006.
Cytoprotection by pyruvate through an anti-oxidative mechanism in cultured rat calvarial osteoblasts.
Moriguchi N*., Hinoi E*., Tsuchihashi Y., Fujimori S., Iemata M., Takarada T., and Yoneda Y.
Histol. Histopathol. 21:969-977. 2006.
DOI: 10.14670/HH-21.969
Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation.
Hinoi E., Fujimori S., Wang L., Hojo H., Uno K., and Yoneda Y.
J. Biol. Chem. 281(26):18015-18024. 2006.
Increased GABA transport activity in rat calvarial osteoblasts cultured under hyperglycemic conditions.
Fujimori S., Osawa M., Iemata M., Hinoi E., and Yoneda Y.
Biol. Pharm. Bull. 29(2):297-301. 2006.
DOI: 10.1248/bpb.29.297
2005
Excitatory amino acid transporters expressed by synovial fibroblasts in rats with collagen-induced arthritis.
Hinoi E., Ohashi R., Miyata S., Kato Y., Iemata M., Hojo H., Takarada T., and Yoneda Y.
Biochem. Pharmacol. 70(12):1744-1755. 2005.
Abolition of chondral mineralization by group III metabotropic glutamate receptors expressed in rodent cartilage.
Wang L*., Hinoi E*., Takemori A., Takarada T., and Yoneda, Y.
Br. J. Pharmacol. 146(5):732-743. 2005.
Release of endogenous glutamate by AMPA receptors expressed in cultured rat costal chondrocytes.
Wang L*., Hinoi E*., Takemori A., and Yoneda Y.
Biol. Pharm. Bull. 28(6):990-993. 2005.
DOI: 10.1248/bpb.28.990
Functional expression of particular isoforms of excitatory amino acid transporters by rodent cartilage.
Hinoi E., Wang L., Takemori A., and Yoneda Y.
Biochem. Pharmacol. 70(1):70-81. 2005.
Protection by exogenous pyruvate through a mechanism related to monocarboxylate transporters against cell death induced by hydrogen peroxide in cultured rat cortical neurons.
Nakamichi N., Kambe Y., Oikawa H., Ogura M., Takano K., Tamaki K., Inoue M., Hinoi E., and Yoneda Y.
J. Neurochem. 93(1):84-93. 2005.
Glutamate transporters as drug targets.
Hinoi E., Takarada T., Tsuchihashi Y., and Yoneda Y.
Curr. Drug Targets CNS Neurol. Disord. 4(2):211-220. 2005.
2004
Accumulation of [3H]glutamate in cultured rat calvarial osteoblasts.
Takarada T., Hinoi E., Fujimori S., Tsuchihashi Y., Ueshima T., Taniura H., and Yoneda Y.
Biochem. Pharmacol. 68(1):177-184. 2004.
Possible expression of functional glutamate transporters in the rat testis.
Takarada T., Hinoi E., Balcar VJ., Taniura H., and Yoneda Y.
J. Endocrinol. 181(2):233-244. 2004.
Glutamate signaling system in bone.
Hinoi E., Takarada T., and Yoneda Y.
J. Pharmacol. Sci. 94(3):215-220. 2004.
DOI: 10.1254/jphs.94.215
Glutamate signaling in peripheral tissues.
Hinoi E., Takarada T., Ueshima T., Tsuchihashi Y., and Yoneda Y.
Eur. J. Biochem. 271(1):1-13. 2004.
Pyruvate as an endogenous antionxidant.
Tsuchihashi Y., Hinoi E., and Yoneda Y.
Recent Res. Devel. Biophys. Biochem. 4:1-13. 2004.
2003
Modulation of cellular differentiation by N-methyl-D-aspartate receptors in osteoblasts.
Hinoi E., Fujimori S., and Yoneda Y.
FASEB J. 17:1532-1534. 2003.
2002
Blockade by N-methyl-D-aspartate of elevation of activator protein-1 binding after stress in rat adrenal gland.
Hinoi E., Fujimori S., Yoneyama M., and Yoneda Y.
J. Neurosci. Res. 70(2):161-171. 2002.
DOI: 10.1002/jnr.10310
Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts.
Hinoi E., Fujimori S., Takarada T., Taniura H., and Yoneda Y.
Biochem. Biophys. Res. Commun. 297(3):452-458. 2002.
Demonstration of expression of mRNA for particular AMPA and kainate receptor subunits in immature and mature cultured rat calvarial osteoblasts.
Hinoi E., Fujimori S., Takemori A., Kurabayashi H., Nakamura Y., and Yoneda Y.
Brain Res. 943(1):112-116. 2002.
Cell death by pyruvate deficiency in proliferative cultured calvarial osteoblasts.
Hinoi E., Fujimori S., Takemori A., and Yoneda Y.
Biochem. Biophys. Res. Commun. 294(5):1177-1183. 2002.
Functional GABAB receptors expressed in cultured calvarial osteoblasts.
Fujimori S., Hinoi E., and Yoneda Y.
Biochem. Biophys. Res. Commun. 293(5):1445-1452. 2002.
Constitutive expression of heterologous N-methyl-D-aspartate receptor subunits in rat adrenal medulla.
Hinoi E., Fujimori S., Nakamura Y., Balcar VJ., Kubo K., Ogita K., and Yoneda Y.
J. Neurosci. Res. 68(1):36-45. 2002.
DOI: 10.1002/jnr.10202
Nuclear transcription factors in the hippocampus.
Hinoi E., Balcar VJ., Kuramoto N., Nakamichi N., and Yoneda Y.
Prog. Neurobiol. 68(2):145-65. 2002.
2001
Expression of GluR6/7 subunits of kainate receptors in rat adenohypophysis.
Hinoi E., and Yoneda Y.
Neurochem. Int. 38(6):539-547. 2001.
Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts.
Hinoi E., Fujimori S., Nakamura Y., and Yoneda Y.
Biochem. Biophys. Res. Commun. 281(2):341-346. 2001.
Characterization with [3H]quisqualate of group I metabotropic glutamate receptor subtype in rat central and peripheral excitable tissues.
Hinoi E., Ogita K., Takeuchi Y., Ohashi H., Maruyama T., and Yoneda Y.
Neurochem. Int. 38(3):277-285. 2001.
Consolidation of transient ionotropic glutamate signals through nuclear transcription factors in the brain.
Yoneda Y., Kuramoto N., Kitayama T., and Hinoi E.
Prog. Neurobiol. 63(6):697-719. 2001.
2000
Direct radiolabeling by [3H]quisqualic acid of group I metabotropic glutamate receptor in rat brain synaptic membranes.
Hinoi E., Ogita K., Takeuchi Y., Ohashi H., Maruyama T., and Yoneda Y.
Brain Res. 881(2):199-203. 2000.
1999
Differential inhibition by ferrous ions of [3H]MK-801 binding to native N-methyl-D-aspartate channel in neonatal and adult rat brains.
Ogita K., Shuto M., Kuramoto N., Manabe T., Hinoi E., Kitayama T., Sakata K., and Yoneda Y.
Brain Res. 818(2):548-552. 1999.
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
St'astny F., Hinoi E., Ogita K., and Yoneda Y.
Neurosci. Lett. 262(2):105-108. 1999.