Acute traumatic brain injured patients with evidence of intracranial, cortical and/or subcortical bleed on CT imaging
Age 6-100 are eligible
GCS 3-13 without continuous sedation at time of enrollment
Ability to enroll within 72 hours of injury
Patients with polytrauma including long bone fractures, blunt trauma, abdominal trauma or similar may be enrolled
Patients with diffuse axonal injury in the absence of hemorrhagic contusions or skull fracture, and isolated epidural hemorrhages that improve after evacuation
No plan for continuous EEG monitoring during injury day 1-7
Inability to undergo MRI within post injury day 1-18 due to bullet, metal implant, pacemaker, etc.
Known HIV/AIDS, Hepatitis B or C
Pregnancy
Pre-existing Neurologic disease ( e.g. TBI, Stroke, or Neurodegenerative disorder)
Pre-existing CNS malignancy
Pre-existing epilepsy/seizure disorder
Pre-existing dementia
Isolated anoxic brain injury
Devastating cervical spine injury
Brain Death
Incarceration present or pending
Inability on part of patient or family to complete the study to Day 730
Positive SARS-CoV-2 (COVID-19) test
Any other condition or situation that the investigator believes may interfere with the safety of the subject or the conduct of the study, to include inability for study completion
Adapted from the EpiBioS4x Protocol V.4.0