Field of interest: enzymology, structural biology, glycoscience
Nature is full of unique organisms. Behind the questions "Why do these organisms have these characteristics?" or "Why do these life phenomena occur?", the genes of the organisms and the activity of their gene products, proteins, and especially enzymes, are often implicated (for more details about enzymes, see "Research" in the Enzymology Laboratory). However, in many cases, a single biological phenomenon is not accomplished by a single enzyme. Kashima focuses on novel enzymes and the proteins that work together with those enzymes, and is engaged in the following research projects.
①How an enzyme "works" and what kind of chemical reaction does it catalyze (Enzyme functional analysis)
②What "form" a single enzyme takes and how it catalyzes chemical reactions (Enzyme structural and molecular functional analysis)
③How multiple enzymes and proteins “cooperate” to accomplish a biological phenomenon (Enzyme group analysis)
Structural analysis of blood type conversion enzyme (type B to type O) from Bifidobacterium bifidum
Kashima T., et al., Journal of Applied Glycosciences, 2024
Study of a group of enzymes that degrade D-arabinan glycans in the cell wall of Mycobacteria
Shimokawa M., Ishiwata A., Kashima T., et al., Nature Communications, 2023
Degradation system of intestinal mucosal mucin-glycan by Bifidobacterium bifidum
Katoh T., et al., Nature Chemical Biology, 2023
Research on enzymes that break down oligosaccharides in caramel by Bifidobacterium denitum
Kashima T., Okumura K., Ishwata A., et al., Journal of Biological Chemistry, 2021, Editor's Pick