論文発表

Upcoming articles

1. T. Ishii, E. Nezu, H. Fuwa

Tandem synthesis of pyrrolidine and piperidine derivatives from propargylic alcohols under multimetallic catalysis

TBA.

2. Y. Takatori, H. Fuwa

Total synthesis of (−)-fasicularin

The Journal of Organic Chemistry, under revision.

2024年

1. T. Masuda,‡ K. Ohyama,‡ A. Yoshimura, H. Fuwa

Total synthesis of (−)-enigmazole A by the macrocyclization/transannular pyran cyclization strategy

Organic Letters, 26, 2045-2050 (2024).

‡Equally contributed.

2. Y. Wada, P. Usov, B. Chan, M. Mukaida, K. Ohmori, Y. Ando, H. Fuwa, H. Ohtsu, M. Kawano

Atomic-resolution structure analysis inside an adaptable porous framework

Nature Communications, 15, Article Number: 81 (2024).

3. H. Fuwa

Pursuing step economy in total synthesis of complex marine macrolide natural products

In Modern Natural Product Synthesis – Overcoming Difficulties, Eds. by M. Nakada, K. Tanino, K. Nagasawa, S. Yokoshima, Springer Nature, 2024, pp. 319-343.

This article was published as an open access article.

4. H. Fuwa

Total synthesis of marine macrolide natural products by the macrocyclization/transannular pyran cyclization strategy

SYNLETT, published online.

This article was written upon invitation from Prof. K. Peter C. Vollhardt, Editor.

2023年

1. Y. Goda, H. Fuwa

Total synthesis of (−)-enigmazole B

Organic Letters, 25, 8402-8407 (2023).

This article was featured on the Front Cover of Organic Letters.

This article was selected as Most Read Articles (October 2023).

2. H. Nakagawa, H. Fuwa

Au-catalyzed stereodivergent synthesis of 2,5-disubstituted pyrrolidines: Total synthesis of (+)-monomorine I and (+)-indolizidine 195B

Chemical Communications, 59, 10121-10124 (2023).

This article was featured in Organic Chemistry Highlights.

3. R. Minami, T. Kasai, K. Murata, H. Fuwa

Total synthesis of (+)-muricatetrocin B via a late-stage Co-catalyzed Hartung–Mukaiyama cyclization

Organic Letters, 25, 5745-5749 (2023).

This article was selected as Most Read Articles (August 2023).

4. R. Hanzawa, H. Fuwa

Collective asymmetric total synthesis of cylindricines

Organic Letters, 25, 1984-1988 (2023).

This work has been deposited as a preprint: ChemRxiv, preprint (2023). DOI: 10.26434/chemrxiv-2023-61f1w

5. K. Nakazato, M. Oda, H. Fuwa

An 11-step synthesis of (+)-neopeltolide by the macrocyclization/transannular pyran cyclization strategy

Bulletin of the Chemical Society of Japan, 96, 257-267 (2023).

6. H. Machida, K. Kanemoto, H. Fuwa

N-Terminal-selective Cu-catalyzed [3+2] cycloaddition for irreversible assembly of two modules with a peptide

ChemRxiv, preprint (2023). DOI: 10.26434/chemrxiv-2023-sxw2w

2022年

1. K. Murata, H. Mori, H. Fuwa

GIAO NMR calculation-driven stereochemical assignment of marine macrolide natural products: Assessment of the performance of DP4 and DP4+ analyses and assignment of the relative configuration of leptolyngbyalide A-C/oscillariolide macrolactone

Bulletin of the Chemical Society of Japan, 95, 1775-1785 (2022).

2. A. Yoshimura,‡ R. Hanzawa,‡ H. Fuwa

Stereoselective tandem synthesis of pyrrolidine derivatives under Au catalysis: An asymmetric synthesis of (−)-lepadiformine A

Organic Letters, 24, 6237-6241 (2022).

‡Equally contributed.

This article was featured on the Front Cover of Organic Letters.

This article was selected as Most Read Articles (August 2022).

3. K. Nakazato, M. Oda, H. Fuwa
   Total synthesis of (+)-neopeltolide by the macrocyclization/transannular pyran cyclization strategy
   Organic Letters, 24, 4003-4008 (2022).

This article was selected as Most Read Articles (July 2022). 

4. E. Benoit, S. Schlumberger, J. Molgó, M. Sasaki, H. Fuwa, R. Bournaud

Gambierol blocks a K+ current fraction without affecting catecholamine release in rat fetal adrenomedullary cultured chromaffin cells
Toxins, 14, 254 (2022).

5. D. Mizukami, K. Iio, M. Oda, Y. Onodera, H. Fuwa
   Tandem macrolactone synthesis: Total synthesis of (−)-exiguolide by a macrocyclization/transannular pyran cyclization strategy
   Angewandte Chemie, International Edition, 61, e202202549 (2022).

This article was featured on the Frontispiece of Angewandte Chemie.

This article was featured in SYNFACTS (by E. M. Carreira and S. M. Papidocha).

This article was highlighted by Simplifying Synthesis.

This article was featured in Organic Chemistry Highlights.

6. S. Raposo-Garcia, M. C. Louzao, H. Fuwa, M. Sasaki, C. Vale, L. M. Botana
   Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
   Food and Chemical Toxicology, 160, 112812 (2022).

7. H. Fuwa
   Total synthesis of (−)-exiguolide, a potent anticancer marine macrolide

Heterocycles, 104, 1709-1743 (2022).

This article was written upon invitation from Executive Editor.

2021年

1. K. Murata, R. Minami, H. Fuwa
   Asymmetric synthesis of (−)-atorvastatin calcium by tandem catalysis
   Bulletin of the Chemical Society of Japan, 94, 2028-2035 (2021).

2. H. Takeshita, T. Sugai, H. Fuwa
   Stereoselective synthesis of the southern hemisphere acyclic domain of neaumycin B
   The Journal of Organic Chemistry, 86, 6787-6799 (2021).

3. K. Nishimura, R. Hanzawa, T. Sugai, H. Fuwa
   Ruthenium-catalyzed intramolecular double hydrofunctionalization of alkynes. Synthesis of spirocyclic hemiaminal ethers and their Lewis acid-mediated cleavage/nucleophilic addition
   The Journal of Organic Chemistry, 86, 6674-6697 (2021).

4. M. Ohta, S. Kato, T. Sugai, H. Fuwa
   Cobalt-catalyzed Hartung-Mukaiyama cyclization of γ-hydroxy olefins: Stereocontrolled synthesis of the tetrahydrofuran moiety of amphidinolide N
   The Journal of Organic Chemistry, 86, 5584-5615 (2021).

5. S. Kato, D. Mizukami, T. Sugai, M. Tsuda, H. Fuwa
   Total synthesis and complete configurational assignment of amphirionin-2
   Chemical Science, 12, 872-879 (2021).
   This article was featured on the Inside Cover of Chemical Science.
   This article was selected as a ChemSci Pick/Chemical Science HOT Article Collection article.
   This article was featured in ChemistryViews "First Total Synthesis of Amphirionin-2"

6. H. Fuwa
   Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis
   Organic Chemistry Frontiers, 8, 3990-4023 (2021).
   This article was written on invitation from Editor-in-Chief.

7. H. Fuwa
   Synthesis-driven stereochemical assignment of marine polycyclic ether natural products
   Marine Drugs, 19, 257 (2021).

2020年

1. K. Sakurai, K. Sakamoto, M. Sasaki, H. Fuwa
   Unified total synthesis of (−)-enigmazole A and (−)-15-O-methylenigmazole A
   Chemistry - An Asian Journal, 15, 3494-3502 (2020).
   This paper was featured in Organic Chemistry Highlights.

2. K. Murata, H. Takeshita, K. Sakamoto, H. Fuwa
   Tandem three-component synthesis of syn-1,2- and syn-1,3-diol derivatives
   Chemistry - An Asian Journal, 15, 807-819 (2020).
   Invited contribution to the special issue for the anniversary of the 100th annual meeting of the Chemical Society of Japan.

3. J. Molgó, S. Schlumberger, M. Sasaki, H. Fuwa, M. C. Louzao, L. M. Botana, D. Servent, E. Benoit
   Gambierol potently increases evoked quantal transmitter release and reverses pre-and post-synaptic blockade at vertebrate neuromuscular junctions
   Neuroscience, 439, 106-116 (2020).

4. T. Sugai, H. Fuwa
   Total synthesis of (−)-enigmazole A
   In Marine Natural Products, H. Kiyota eds., Topics in Heterocyclic Chemistry, Vol. 58, pp. 361-386 (2020), Springer, Singapore.

5. 村田佳亮、不破春彦
   タンデム反応と複雑天然物の全合成
   化学工業, 71, 117-124 (2020).

2019年

1. S. Yanagi, T. Sugai, T. Noguchi, M. Kawakami, M. Sasaki, S. Niwa, A. Sugimoto, H. Fuwa
   Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging
   Organic & Biomolecular Chemistry, 17, 6771-6776 (2019).

2. K. Sakamoto, A. Hakamata, A. Iwasaki, K. Suenaga, M. Tsuda, H. Fuwa
   Total synthesis, stereochemical revision, and biological assessment of iriomoteolide-2a
   Chemistry - A European Journal, 25, 8528-8542 (2019).
   This paper was selected as VIP "Very Important Paper".
   This paper was featured on the Inside Cover.

3. K. Murata, K. Sakamoto, H. Fuwa
   Stereoselective tandem synthesis of syn-1,3-diol derivatives by integrating olefin cross-metathesis, hemiacetalization, and intramolecular oxa-Michael addition
   Organic Letters, 21, 3730-3734 (2019).

4. 坂本渓太、不破春彦
   海洋マクロリド天然物iriomoteolide-2aの全合成：複雑な天然物の構造決定と生物活性評価における全合成の役割
   有機合成化学協会誌, 77, 831-840 (2019).

2018年

1. K. Iio, S. Sachimori, T. Watanabe, H. Fuwa
   Ruthenium-catalyzed intramolecular double hydroalkoxylation of internal alkynes
   Organic Letters, 20, 7851-7855 (2018).

2. K. Sakurai, M. Sasaki, H. Fuwa
   Total synthesis of (−)-enigmazole A
   Angewandte Chemie, International Edition, 57, 5143-5146 (2018).
   This paper was featured in SYNFACTS (by E. M. Carreira and R. J. Gillespie).

This paper was highlighted in Organic Chemistry Highlights. 

3. K. Sakamoto, A. Hakamata, M. Tsuda, H. Fuwa
   Total synthesis and stereochemical revision of iriomoteolide-2a
   Angewandte Chemie, International Edition, 57, 3801-3805 (2018).

4. 不破春彦、坂本渓太
   プレウロムチリンの全合成ー独創的な合成戦略から垣間見えること
   化学, 73 (6), 66-67 (2018).

5. 不破春彦、佐々木誠
   ガンビエロール構造簡略体の設計・合成・生物機能
   CSJカレントレビュー27 天然有機化合物の全合成：独創的なものづくりの反応と戦略, 化学同人 (2018).

2017年

1. H. Fuwa, M. Sato
   A synthetic analogue of neopeltolide, 8,9-dehydroneopeltolide, is a potent anti-austerity agent against starved tumor cells
   Marine Drugs, 15, 320 (2017).
   This article was written on invitation from Editor and selected as "Featured Article".

2. E. Alonso, A. C. Vieira, I. Rodriguez, R. Alvarino, S. Gegunde, H. Fuwa, Y. Suga, M. Sasaki, A. Alfonso, J. M. Cifuentes, L. M. Botana
   Tetracyclic truncated analogue of the marine toxin gambierol modifies NMDA, Tau, and amyloid beta expression in mice brains: Implications in AD pathology
   ACS Chemical Neuroscience, 8, 1358-1367 (2017).