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Principal Investigator
Dr. Martin G. Frasch, MD, PhD [publications | preprints | Google Scholar | ORCID | LinkedIn | ResearchGate | Loop | GitHub| Hackerrank]
As a neuroscientist, I am working on improving perinatal health outcomes by deepening our understanding of the brain's responses to antepartum and perinatal asphyxia, inflammation/infection, and stress. My lab uses modern machine learning (ML) techniques for signal analyses (e.g., see here) combined with A.I. frameworks to convert the medical data deluge into representations of physiological phenotypes carrying individualized predictive potential (e.g., see here).
I believe that such an approach will render new treatment options and help prevent or mitigate long-term sequelae of prenatal or perinatal exposures to harmful stimuli, resulting in brain, gut, or heart injuries. My lab has been developing non-invasive monitoring technologies (ECG, EEG) to help detect babies at risk.
In the preclinical line of research, I have been interested in how prenatal events harmful to the baby, e.g., infection, shape brain development after birth, with a focus on glial biology, particularly microglia and astrocytes. Understanding this connection is relevant to research in the etiology of adult neuroinflammatory and neurodegenerative diseases such as Multiple Sclerosis and Alzheimer's. You can find more about this on my neuroinflammation page. Excitingly, this preclinical work is connected to the fetal health monitoring idea my lab has pursued: the bioelectronic medicine approach holds promise for monitoring and manipulating the "vagus code" to detect, predict, and restore pathophysiological brain states at early stages of developmental trajectories.
Feel free to ask any questions about our research here.
My team
Current trainees (and collaborators involved in co-supervision)
Clara Becker (doctorate, co-supervision with Drs. Marta Antonelli and Silvia Lobmaier)
Mariana Falcao, MD, (doctorate, co-supervision with Dr. Silvia Lobmaier)
Collaborators (an incomplete list)
Dr. Marta Antonelli, PhD
Dr. Silvia Lobmaier, MD PhD
Dr. Reinhard Bauer, MD PhD
Dr. Byung-Jun Yoon, PhD
Dr. Hermona Soreq, PhD
Dr. William Fifer, PhD
Dr. Andrew Seely, MD PhD
Dr. Mary Wallingford, PhD
Dr. André Desrochers, DMV, MS, DACVS & DECBHM
Dr. Gilles Fecteau, DMV, DACVIM
Dr. Hau-tieng Wu, MD, PhD
Dr. Patrick Burns, BVSc, MANZCVS, DACVA
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