The MAE156B Final Report presents an automated barrel-cleaning system designed to improve efficiency and ergonomics at Genentech. The system replaces the manual wipe-down process with a multi-step cleaning solution, including onloading/offloading mechanisms, spraying systems, rotary brushes for top, side, and bottom cleaning, and a roller transport system. Prototype testing showed improvements in cleaning efficiency but highlighted areas for refinement, such as brush adjustments and motorized transport. Future recommendations include encasing the system, upgrading motors, and integrating a conveyor for full automation. The project aims to enhance workplace safety and streamline pharmaceutical production, with the potential for broader industry adoption.Â