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Visualize T-cells Using Magnetic Resonance Imaging via a MRI Reporter Gene
BENG 187 Senior Design Group 35: Mitchell Kong, Yuzhou Tong, and Yingxiao Wang (Mentor)
Mission of the project
Mission of the project
We need to develop an imaging-based detection method for cancers which can determine whether programmed T-cells have successfully recognized tumor antigens in vivo.
Objectives
Objectives
1. Develop a method for imaging live cells using MRI
1. Develop a method for imaging live cells using MRI
2. Achieve Longitudinal MR Imaging
2. Achieve Longitudinal MR Imaging
3. Ensure our final design will not damage living organisms
3. Ensure our final design will not damage living organisms
4. Improve safety level of CAR-T therapy with visualization
4. Improve safety level of CAR-T therapy with visualization
References:
Anatomy, G. Google Images
Bourre, L. “How to Assess CAR-T Cell Therapies Preclinically.” February 20, 2018
Kim, H.S.; Woo, J.; Choi, Y.; Hwang, E.H.; Choi, S.K.; Cho, K.W.; Moon, W.K. Noninvasive MRI and multilineage differentiation capability of ferritin-transduced human mesenchymal stem cells. NMR Biomed. 2015, 28, 168–179
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