Publications
Check out our Google Scholar Profile for the most up-to-date list of publications.
2023
NEW Mogi, K., Akiyama, U., Futagawa, N., Tamura, K., Kamiya, M., Mizuta, M., Yamaoka, M., Kamimura, I., Kuze-Arata, Sayaka., & Kikusui, T. (2023) Intergenerational transmission of maternal behavioral traits in mice: Involvement of the gut microbiota. Frontiers in Neuroscience, 17, 1302841. https://www.frontiersin.org/articles/10.3389/fnins.2023.1302841/full
Koyasu, H., Ogasawara, S., Kikusui, T., & Nagasawa, M. (2023). Ownership of dogs and cats leads to higher levels of well-being and general trust through family involvement in late adolescence. Frontiers in Veterinary Science, 10. https://doi.org/10.3389/fvets.2023.1220265
Takagi, S., Koyasu, H., Hattori, M., Nagasawa, T., Maejima, M., Nagasawa, M., Kikusui, T., & Saito, A. (2023). Effects of the COVID-19 Pandemic on the Behavioural Tendencies of Cats and Dogs in Japan. Animals, 13(13), 2217. https://doi.org/10.3390/ani13132217
Nagasawa, M., Saito, M., Hirasawa, H., Mogi, K., & Kikusui, T. (2023). Dogs showed lower parasympathetic activity during mutual gazing while owners did not. The Journal of Physiological Sciences, 73(1), 1-11. https://doi.org/10.1186/s12576-023-00863-7
Diaz-Rojas, F., Matsunaga, M., Tanaka, Y., Kikusui, T., Mogi, K., Nagasawa, M., ... & Myowa, M. (2023). Development of the paternal brain in humans throughout pregnancy. Journal of Cognitive Neuroscience, 35(3), 396-420. https://doi.org/10.1162/jocn_a_01953
2022
Koyasu, H., Takahashi, H., Sasao, I., Takagi, S., Nagasawa, M., & Kikusui, T. (2022). Sociality of Cats toward Humans Can Be Influenced by Hormonal and Socio-Environmental Factors: Pilot Study. Animals, 13(1), 146. https://doi.org/10.3390/ani13010146
Hattori, M., Saito, A., Nagasawa, M., Kikusui, T., & Yamamoto, S. (2022). Changes in Cat Facial Morphology Are Related to Interaction with Humans. Animals, 12(24), 3493; https://www.mdpi.com/2076-2615/12/24/3493
ヒトに飼われているネコは、野生の猫と比べて、鼻の長さが短く、目の角度が低いことがわかり、これらの形態変化は「可愛らしさ」の評価に影響することを明らかにしました。ヒトと暮らし、ヒトとの相互作用によって飼い猫の顔形態は変化してきたと考えられます。京都大学・上智大学との共同研究です。
Matsushita, S., Nagasawa, M., & Kikusui, T. (2022). Autonomic nervous system responses of dogs to human-dog interaction videos. Plos one, 17(11), e0257788. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257788
ヒトが犬と触れ合っている様子をプロジェクターで映し出し、被験イヌに呈示したところ、ヒトが犬と触れ合っていない映像を注視した条件と比較して、心拍変動（R-R間隔の標準偏差）が低くなりました。このことから、イヌはビデオで再生される二次元の社会刺激に対しても情動反応を示すことが明らかとなり、また、飼い主への愛着が強いイヌほど、自己（被験イヌ）の映像刺激と他の犬の映像刺激の違いに対する情動反応が明瞭であることも明らかにしました。大学プレスリリースはこちら
Asaba, A., Nomoto, K., Osakada, T., Matsuo, T., Kobayakawa, K., Touhara, K., Mogi, K., & Kikusui, T. (2022). Prelimbic cortex responds to male ultrasonic vocalizations in the presence of a male pheromone in female mice. Frontiers in Neural Circuits, 100. Frontiers in Neural Circuits
オスマウスの超音波発声を呈示した際のメスマウスの脳活動を調べたところ、前辺縁皮質 (Prelimbic Cortex: PrL) がオスの音声に反応し、これによりメスマウスの求愛行動を促進している可能性を明らかにしました。東京大学・関西医科大学との共同研究です。
Murata, K., Nagasawa, M., Onaka, T., Kanemaki, N., Nakamura, S., Tsubota, K., Mogi, K., & Kikusui, T. (2022). Increase of tear volume in dogs after reunion with owners is mediated by oxytocin. Current Biology, 32(16), R869-R870. https://www.sciencedirect.com/science/article/pii/S0960982222011320
イヌは情動の変化に伴って涙の分泌量が増えること、涙の分泌にオキシトシンが関与することを明らかにしました。自治医科大学・慶應義塾大学との共同研究です。★国内外多数のメディアに取り上げられました (Newsに移動します)
Koyasu, H., Takahashi, H., Yoneda, M., Naba, S., Sakawa, N., Sasao, I., ... & Kikusui, T. (2022). Correlations between behavior and hormone concentrations or gut microbiome imply that domestic cats (Felis silvestris catus) living in a group are not like ‘groupmates’. PloS one, 17(7), e0269589. https://doi.org/10.1371/journal.pone.0269589
ネコがテストステロン値やコルチゾール値が低くなることにより、同じ空間を共有して集団生活が可能となるものの、オキシトシンの機能は仲間に対する親和的なものとは異なり、ネコは同じ空間で生活している他個体を仲間とみなしていない可能性を明らかにしました。
Tonoike, A., Otaki, K. I., Terauchi, G., Ogawa, M., Katayama, M., Sakata, H., Miyasako, F., Mogi, K., Kikusui, T., & Nagasawa, M. (2022). Identification of genes associated with human-canine communication in canine evolution. Scientific Reports, 12(1), 1-10. https://www.nature.com/articles/s41598-022-11130-x
ストレスホルモンであるコルチゾールの産生に関与するメラノコルチン2受容体遺伝子の2つの変異が、ヒトと交流しコミュニケーションをとるためのイヌの社会的認知能力を発達させ、イヌの家畜化に関連している可能性があることを明らかにしました。
Shinoda, K., Kosaki, Y., Nagasawa, M., & Kikusui, T. (2022). Measurement of the exploration–exploitation response of dogs through a concurrent visual discrimination task. Behavioural Processes, 199, 104644. https://www.sciencedirect.com/science/article/abs/pii/S0376635722000614
イヌの探索反応と搾取反応の配分を測定したところ、イヌは見慣れた刺激よりも新規の刺激を好み、より多くの反応を探索に割り当てる可能性が高いことが示唆されました。
Koyasu, H., Goto, R., Takagi, S., Nagasawa, M., Nakano, T., & Kikusui, T. (2022). Mutual synchronization of eyeblinks between dogs/cats and humans. Current zoology, 68(2), 229-232. https://doi.org/10.1093/cz/zoab045
ヒトとイヌ・ネコの間でまばたきの相互同調が存在することを明らかにしました。またこのまばたきの同期化は、まばたきの速度増加によるものではなく、自発的なまばたきのタイミングを相手のタイミングに合わせることによって生じていることが示唆されました。
Sato, D. X., Inoue, Y. U., Kuga, N., Hattori, S., Nomoto, K., Morimoto, Y., ... & Kawata, M. (2022). Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety. Iscience, 25(8), 104800. https://www.sciencedirect.com/science/article/pii/S2589004222010720
Takagi, S., Saito, A., Arahori, M., Chijiiwa, H., Koyasu, H., Nagasawa, M., ... & Kuroshima, H. (2022). Cats learn the names of their friend cats in their daily lives. Scientific reports, 12(1), 1-9. https://www.nature.com/articles/s41598-022-10261-5
Buffenstein, R., Amoroso, V., Andziak, B., Avdieiev, S., Azpurua, J., Barker, A. J., ... & Smith, E. S. J. (2022). The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology. Biological Reviews, 97(1), 115-140. https://doi.org/10.1111/brv.12791
Ohno, K., Sato, K., Hamada, R., Kubo, T., Ikeda, K., Nagasawa, M., ... & Tadokoro, S. (2022). Electrocardiogram Measurement and Emotion Estimation of Working Dogs. IEEE Robotics and Automation Letters, 7(2), 4047-4054. https://ieeexplore.ieee.org/abstract/document/9691886
2021
Oguchi, M., Tanaka, S., Pan, X., Kikusui, T., Moriya-Ito, K., Kato, S., ... & Sakagami, M. (2021). Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain. Communications biology, 4(1), 1-18. https://www.nature.com/articles/s42003-021-02623-y
Nagasawa, M., Shibata, Y., Yonezawa, A., Takahashi, T., Kanai, M., Ohtsuka, H., ... & Kikusui, T. (2021). Basal cortisol concentrations related to maternal behavior during puppy development predict post-growth resilience in dogs. Hormones and Behavior, 136, 105055. https://doi.org/10.1016/j.yhbeh.2021.105055
Nagasawa, M., Kuramochi, S., Hamamoto, A., Yamakawa, T., & Kikusui, T. (2021). A Pilot Study of the Effects of Human Intervention on Canine Group Movement Behavior. Journal of Robotics and Mechatronics, 33(3), 572-581. https://www.jstage.jst.go.jp/article/jrobomech/33/3/33_572/_article/-char/ja/
Brooks, J., Kano, F., Sato, Y., Yeow, H., Morimura, N., Nagasawa, M., ... & Yamamoto, S. (2021). Divergent effects of oxytocin on eye contact in bonobos and chimpanzees. Psychoneuroendocrinology, 125, 105119. https://www.sciencedirect.com/science/article/abs/pii/S0306453020305424
Koyasu, H., Goto, R., Takagi, S., Nagasawa, M., Nakano, T., & Kikusui, T. (2022). Mutual synchronization of eyeblinks between dogs/cats and humans. Current zoology, 68(2), 229-232. https://academic.oup.com/cz/article/68/2/229/6292112
Kikusui, T., Sonobe, M., Yoshida, Y., Nagasawa, M., Ey, E., De Chaumont, F., ... & Mogi, K. (2021). Testosterone increases the emission of ultrasonic vocalizations with different acoustic characteristics in mice. Frontiers in Psychology, 2359. https://www.frontiersin.org/articles/10.3389/fpsyg.2021.680176/full
The Gaze Communications Between Dogs/Cats and Humans: Recent Research Review and Future Directions
Hikari Koyasu Takefumi Kikusui, Saho Takagi and Miho Nagasawa
Front. Psychol., 18 December 2020 | https://doi.org/10.3389/fpsyg.2020.613512
イヌとネコがヒト社会に融合した背景として考えられる視線コミュニケーションに関して、これまでの研究をまとめ、進化的ならびに家畜化プロセスから考察しました。
Hypothalamic Perifornical Urocortin-3 Neurons Modulate Defensive Responses to a Potential Threat Stimulus.
Noriko Horii-Hayashi, Kensaku Nomoto, Nozomi Endo, Akihiro Yamanaka, Takefumi Kikusui, Mayumi Nishi
Development of the Paternal Brain in Expectant Fathers During Early Pregnancy
Françoise Diaz-Rojas, Michiko Matsunaga; Yukari Tanaka; Takefumi Kikusui; Kazutaka Mogi; Miho Nagasawa; Kohei Asano; Nobuhito Abe; Masako Myowa
NeuroImage. in press
Validation of a newly generated oxytocin antibody for enzyme-linked immunosorbent assays
Kaori Murata, Miho Nagasawa, Tatsushi Onaka, Ken-Ichi Takeyama, Takefumi Kikusui
"Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal"
Yuki Oiwa, Kaori Oka, Hironobu Yasui, Kei Higashikawa, Hidemasa Bono, Yoshimi Kawamura, Shingo Miyawaki, Akiyuki Watarai, Takefumi Kikusui, Atsushi Shimizu, Hideyuki Okano, Yuji Kuge, Kazuhiro Kimura, Yuko Okamatsu-Ogura, and Kyoko Miura.
"Testosterone regulates emission of ultrasonic vocalizations and mounting behavior during different developmental periods in mice"
Takefumi Kikusui, Yuichi Shima, Miku Sonobe, Yuuki Yoshida, Miho Nagasawa, Kensaku Nomoto, Kazutaka Mogi
Maternal approach behaviors toward neonatal calls are impaired by mother’s experiences of raising pups with a risk gene variant for autism.
Risa Kato, Akihiro Machida, Kensaku Nomoto, Gina Kang, Takeshi Hiramoto, Kenji Tanigaki, Kazutaka Mogi, Noboru Hiroi, Takefumi Kikusui
Familiarity with humans affect dogs’ tendencies to follow human majority groups.
Miho Nagasawa, Kazutaka Mogi, Hisashi Ohtsuki & Takefumi Kikusui.
Association between Pet Ownership and Obesity: A Systematic Review and Meta-Analysis.
Kenta Miyake 1,†,Kumiko Kito 2,†OrcID,Ayaka Kotemori 1,3,†,Kazuto Sasaki 4,Junpei Yamamoto 1,3,Yuko Otagiri 5,Miho Nagasawa 3,6,Sayaka Kuze-Arata 3,6,Kazutaka Mogi 3,6,Takefumi Kikusui 3,6 andJunko Ishihara 1,3,*
International Journal of Environmental Research and Public Health in press
Early weaning augments the spontaneous release of dopamine in the amygdala but not the prefrontal cortex: An in vivo microdialysis study of male rats
Takita M and Kikusui T.
Experimental Animals.
Female C57BL/6 and BALB/c mice differently use the acoustic features of male ultrasonic vocalizations for social preferences.
Kensaku NOMOTO, Akiko HASHIGUCHI, Akari ASABA, Takuya OSAKADA, Masahiro KATO, Nobuyoshi KOSHIDA, Kazutaka MOGI, Takefu mi KIKUSUI
Experimental Animals Online ISSN : 1881-7122
雌マウスは自分と異なる系統のオスの歌う超音波音声に嗜好性を示します。今回、C57/B6JとBALB/cAのマウスを用いて、音声の周波数はシラブルのどれが嗜好性に関わるかを調べました。C57Bl6では周波数を中心に、BALB/CAではシラブルと周波数の両方が関わることが明らかになりました。この成果はExperimental Animalsに掲載されました。
Michiko Matsunaga, Takefumi Kikusui, Kazutaka Mogi, Miho Nagasawa, Rumi Ooyama, Masako Myowa Breastfeeding dynamically changes endogenous oxytocin levels and emotion recognition in mothers. Biology Letters in press
Endo K, Yamasaki S, Ando S, Kikusui T, Mogi K, Nagasawa M, Kamimura I, Ishihara J, Nakanishi M, Usami S, Hiraiwa-Hasegawa M, Kasai K, Nishida A. Dog and Cat Ownership Predicts Adolescents' Mental Well-Being: A Population-Based Longitudinal Study. International Journal of Environmental Research and Public Health 17(3) 2020
Takefumi Kikusui, Miho Nagasawa, Kensaku Nomoto, Sayaka Arata, and Kazutaka Mogi. Endocrine regulations in human-dog coexistence through domestication. Trends in Endocrinology and Metabolism Volume 30, Issue 11, November 2019, Pages 793-806.
イヌとヒトはなぜ共同体を形成できるようになったのでしょうか。そのメカニズムの1つとして、内分泌変化に着目し、その社会機構を洞察しつつ、ヒトイヌの特異性の解明を試みました。
Hiroyuki Nishinoma, Kazunori Ohno, Takefumi Kikusui, Miho Nagasawa, Naoko Tsuchihashi, Shohei Matsushita, Tomoha Mikayama, Sakiko Tomori, Maaya Saito, Mikuru Murayama, Satoshi Tadokoro. Canine Motion Control using Bright Spotlight Devices Mounted on a Suit. IEEE Transactions on Medical Robotics and Bionics. 1 (3), 2019
T Sakamoto, Y Ishio, Y Ishida, K Mogi, T Kikusui. Low maternal care enhances the skin barrier resistance of offspring in mice. PloS one 14 (7), e0219674, 2019
Atsushi Kawada, Miho Nagasawa, Aiko Murata, Kazutaka Mogi, Katsumi Watanabe, Takefumi Kikusui, Tatsuya Kameda . Vasopressin enhances human preemptive strike in both males and females. Scientific reports 9 (1), 9664, 2019
東京大学社会心理の亀田達也先生との共同研究です。ヒトを対象に、ヴァソプレシンのもつ社会機構を明らかにしました。
Takefumi Kikusui, Natsumi Kanbara, Mariya Ozaki, Nozomi Hirayama, Kumiko Ida, Mika Tokita, Naho Tanabe, Kuriko Mitsuyama, Hatsuki Abe, Miki Yoshida, Miho Nagasawa, Kazutaka Mogi. Early weaning increases anxiety via brain-derived neurotrophic factor signaling in the mouse prefrontal cortex. Scientific reports 9 (1), 3991, 2019
Maki Katayama, Takatomi Kubo, Toshitaka Yamakawa, Koichi Fujiwara, Kensaku Nomoto, Kazushi Ikeda, Kazutaka Mogi, Miho Nagasawa, Takefumi Kikusui. Emotional contagion from humans to dogs is facilitated by duration of ownership. Frontiers in psychology 10, 1678、2019 https://doi.org/10.3389/fpsyg.2019.01678
今回、ヒトとイヌという異種間（遺伝的には関係のない個体間）において、飼育期間が長いことつまり生活環境の共有が長いことによって情動伝染が起こりやすいことが示され、進化理論に合致した結果となりました。ヒトとイヌの共生の歴史において、情動伝染の存在は、相互理解や協力関係の構築において重要であると思われます。今回の結果から、ヒトとイヌの長くそして深い関係性の一端が明らかになりました。
この成果は2019年7月19日（中央ヨーロッパ標準時）に[Frontiers in Psychology]に掲載されました。
I Kamimura, A Watarai, T Takamura, A Takeo, K Miura, H Morita, K Mogi, T. Kikusui. Gonadal steroid hormone secretion during the juvenile period depends on host‐specific microbiota and contributes to the development of odor preference. Developmental psychobiology. Volume61, Issue5. 2019. https://doi.org/10.1002/dev.21827
Kazunori Ohno, Ryunosuke Hamada, Tatsuya Hoshi, Hiroyuki Nishinoma, Shumpei Yamaguchi, Solvi Arnold, Kimitoshi Yamazaki, Takefumi Kikusui, Satoko Matsubara, Miho Nagasawa, Takatomi Kubo, Eri Nakahara, Yuki Maruno, Kazushi Ikeda, Toshitaka Yamakawa, Takeshi Tokuyama, Ayumi Shinohara, Ryo Yoshinaka, Diptarama Hendrian, Kaizaburo Chubachi, Satoshi Kobayashi, Katsuhito Nakashima, Hiroaki Naganuma, Ryu Wakimoto, Shu Ishikawa, Tatsuki Miura, Satoshi Tadokoro. Cyber-Enhanced Rescue Canine. Disaster Robotics, 143-193
T Kikusui. Social Neuroscience: How does social enrichment produce health benefits? Elife 7, e43666.
Kazunori Ohno, Shumpei Yamaguchi, Hiroyuki Nishinoma, Tatsuya Hoshi, Ryunosuke Hamada, Satoko Matsubara, Miho Nagasawa, Takefumi Kikusui, Satoshi Tadokoro. Control of Canine’s Moving Direction by Using On-suit Laser Beams. 2018 IEEE International Conference on Cyborg and Bionic Systems (CBS), 59-64
WataraiA, Arai N, Miyawaki S, Okano H, Miura M, Mogi K, Kikusui T. “Responses to Pup Vocalizations in Subordinate Naked Mole-Rats Is Induced by Estradiol Ingested through Coprophagy of Queen’s Feces" Proc. Nat. Acad. Sci USA. 115 (37), 9264-9269. https://doi.org/10.1073/pnas.1720530115
K. Nomoto, M. Ikumi, M. Otsuka, K. Mogi and T. Kikusui. “Female mice exhibit both sexual and social partner preferences for vocalizing males" Integrative Zoology. Volume13, Issue6. https://doi.org/10.1111/1749-4877.12357
Kikusui T, Kajita M, Otsuka N, Hattori T, Kumazawa K, Watarai A, Nagasawa M, Inutsuka A, Yamanaka A, Matsuo N, Covington HE 3rd, Mogi K. Sex differences in olfactory-induced neural activation of the amygdala. Behav Brain Res. 2018 Jul 2;346:96-104. doi: 10.1016/j.bbr.2017.11.034. Epub 2017 Dec 2. PubMed PMID: 29203334.
Hattori T, Osakada T, Masaoka T, Ooyama R, Horio N, Mogi K, Nagasawa M,Haga-Yamanaka S, Touhara K, Kikusui T. Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal Responsible for the Bruce Effect in Mice. Curr Biol. 2017 Oct 23;27(20):3197-3201.e3. doi: 10.1016/j.cub.2017.09.013. Epub 2017 Oct 12. PubMed PMID: 29033330.
Nagasawa M, Ogawa M, Mogi K, Kikusui T. Intranasal Oxytocin Treatment Increases Eye-Gaze Behavior toward the Owner in Ancient Japanese Dog Breeds. Front Psychol. 2017 Sep 21;8:1624. doi: 10.3389/fpsyg.2017.01624. eCollection 2017. PubMed PMID: 28983270; PubMed Central PMCID: PMC5613112.
Inokuchi K, Imamura F, Takeuchi H, Kim R, Okuno H, Nishizumi H, Bito H, Kikusui T, Sakano H. Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses. Nat Commun. 2017 Jul 21;8:15977. doi: 10.1038/ncomms15977. PubMed PMID: 28731029; PubMed Central PMCID: PMC5525001.
Saito H, Nishizumi H, Suzuki S, Matsumoto H, Ieki N, Abe T, Kiyonari H, Morita M, Yokota H, Hirayama N, Yamazaki T, Kikusui T, Mori K, Sakano H. Immobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT. Nat Commun. 2017 Jul 7;8:16011. doi:10.1038/ncomms16011. PubMed PMID: 28685774; PubMed Central PMCID: PMC5504302.
Okabe S, Tsuneoka Y, Takahashi A, Ooyama R, Watarai A, Maeda S, Honda Y, Nagasawa M, Mogi K, Nishimori K, Kuroda M, Koide T, Kikusui T. Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice. Psychoneuroendocrinology. 2017 May;79:20-30. doi: 10.1016/j.psyneuen.2017.01.036.Epub
Kikusui T, Ishio Y, Nagasawa M, Mogil JS, Mogi K. Early weaning impairs a social contagion of pain-related stretching behavior in mice. Dev Psychobiol. 2016 Dec;58(8):1101-1107. doi: 10.1002/dev.21443. Epub 2016 Jul 1. PubMed PMID:27364014.
Kikusui T, Hiroi N. A Self-Generated Environmental Factor as a Potential Contributor to Atypical Early Social Communication in Autism. Neuropsychopharmacology. 2017 Jan;42(1):378. doi: 10.1038/npp.2016.225. PubMed PMID: 27909329; PubMed Central PMCID: PMC5143512.
Mogi K, Takakuda A, Tsukamoto C, Ooyama R, Okabe S, Koshida N, Nagasawa M, Kikusui T. Mutual mother-infant recognition in mice: The role of pup ultrasonic vocalizations. Behav Brain Res. 2017 May 15;325(Pt B):138-146. doi: 10.1016/j.bbr.2016.08.044. Epub 2016 Aug 24. PubMed PMID: 27567527.
Mogi K, Ishida Y, Nagasawa M, Kikusui T. Early weaning impairs fear extinction and decreases brain-derived neurotrophic factor expression in the prefrontal cortex of adult male C57BL/6 mice. Dev Psychobiol. 2016 Dec;58(8):1034-1042. doi: 10.1002/dev.21437. Epub 2016 Jun 13. PubMed PMID: 27298086.
Hattori T, Osakada T, Matsumoto A, Matsuo N, Haga-Yamanaka S, Nishida T, Mori Y, Mogi K, Touhara K, Kikusui T. Self-Exposure to the Male Pheromone ESP1 Enhances Male Aggressiveness in Mice. Curr Biol. 2016 May 9;26(9):1229-34. doi: 10.1016/j.cub.2016.03.029. Epub 2016 Apr 14. PubMed PMID: 27151664.
Katayama M, Kubo T, Mogi K, Ikeda K, Nagasawa M, Kikusui T. Heart rate variability predicts the emotional state in dogs. Behav Processes. 2016 Jul;128:108-12. doi: 10.1016/j.beproc.2016.04.015. Epub 2016 Apr 26. PubMed PMID: 27129806.
Ohkita M, Nagasawa M, Kazutaka M, Kikusui T. Owners' direct gazes increase dogs' attention-getting behaviors. Behav Processes. 2016 Apr;125:96-100. doi:10.1016/j.beproc.2016.02.013. Epub 2016 Feb 23. PubMed PMID: 26915425.
Tonoike A, Nagasawa M, Mogi K, Serpell JA, Ohtsuki H, Kikusui T. Comparison of owner-reported behavioral characteristics among genetically clustered breeds of dog (Canis familiaris). Sci Rep. 2015 Dec 18;5:17710. doi: 10.1038/srep17710. PubMed PMID: 26680442; PubMed Central PMCID: PMC4683527.
Takahashi T, Okabe S, Broin PÓ, Nishi A, Ye K, Beckert MV, Izumi T, Machida A, Kang G, Abe S, Pena JL, Golden A, Kikusui T, Hiroi N. Structure and function of neonatal social communication in a genetic mouse model of autism. Mol Psychiatry. 2016 Sep;21(9):1208-14. doi: 10.1038/mp.2015.190. Epub 2015 Dec 15. PubMed PMID: 26666205; PubMed Central PMCID: PMC4909589.
Nagasawa M, Kanbayashi S, Mogi K, Serpell JA, Kikusui T. Comparison of behavioral characteristics of dogs in the United States and Japan. J Vet Med Sci. 2016 Feb;78(2):231-8. doi: 10.1292/jvms.15-0253. Epub 2015 Sep 27. PubMed PMID: 26412048; PubMed Central PMCID: PMC4785111.
Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T. Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds. Science. 2015 Apr 17;348(6232):333-6. doi: 10.1126/science.1261022. Epub 2015 Apr 16. PubMed PMID: 25883356.
Matsuo T, Hattori T, Asaba A, Inoue N, Kanomata N, Kikusui T, Kobayakawa R, Kobayakawa K. Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):E311-20. doi: 10.1073/pnas.1416723112. Epub 2015 Jan 6. PubMed PMID: 25564662; PubMed Central PMCID: PMC4311817.
Hattori T, Kanno K, Nagasawa M, Nishimori K, Mogi K, Kikusui T. Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice. Neurosci Res. 2015 Jan;90:90-4. doi: 10.1016/j.neures.2014.05.003. Epub 2014 Jun 12. PubMed PMID: 24929102.
Romero T, Nagasawa M, Mogi K, Hasegawa T, Kikusui T. Oxytocin promotes social bonding in dogs. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9085-90. doi: 10.1073/pnas.1322868111. Epub 2014 Jun 9. PubMed PMID: 24927552; PubMed Central PMCID: PMC4078815.
Mogi K, Ooyama R, Nagasawa M, Kikusui T. Effects of neonatal oxytocin manipulation on development of social behaviors in mice. Physiol Behav. 2014 Jun 22;133:68-75. doi: 10.1016/j.physbeh.2014.05.010. Epub 2014 May 21. PubMed PMID: 24857720.
Nagasawa M, Kawai E, Mogi K, Kikusui T. Dogs show left facial lateralization upon reunion with their owners. Behav Processes. 2013 Sep;98:112-6. doi:10.1016/j.beproc.2013.05.012. Epub 2013 May 30. PubMed PMID: 23727034.
Esposito G, Yoshida S, Ohnishi R, Tsuneoka Y, Rostagno Mdel C, Yokota S, Okabe S, Kamiya K, Hoshino M, Shimizu M, Venuti P, Kikusui T, Kato T, Kuroda KO. Infant calming responses during maternal carrying in humans and mice. Curr Biol. 2013 May 6;23(9):739-45. doi: 10.1016/j.cub.2013.03.041. Epub 2013 Apr 18. PubMed PMID: 23602481.
Nagasawa M, Mogi K, Kikusui T. Continued distress among abandoned dogs in Fukushima. Sci Rep. 2012;2:724. doi: 10.1038/srep00724. Epub 2012 Oct 11. PubMed PMID: 23061007; PubMed Central PMCID: PMC3468835.
Nagasawa M, Okabe S, Mogi K, Kikusui T. Oxytocin and mutual communication in mother-infant bonding. Front Hum Neurosci. 2012 Feb 28;6:31. doi: 10.3389/fnhum.2012.00031. eCollection 2012 Jan 30. PubMed PMID: 22375116; PubMed Central PMCID: PMC3289392.
Nagasawa M, Murai K, Mogi K, Kikusui T. Dogs can discriminate human smiling faces from blank expressions. Anim Cogn. 2011 Jul;14(4):525-33. doi: 10.1007/s10071-011-0386-5. Epub 2011 Feb 26. PubMed PMID: 21359654.
Haga S, Hattori T, Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K. The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor. Nature. 2010 Jul 1;466(7302):118-22. doi: 10.1038/nature09142. PubMed PMID: 20596023.
Nagasawa M, Kikusui T, Onaka T, Ohta M. Dog's gaze at its owner increases owner's urinary oxytocin during social interaction. Horm Behav. 2009 Mar;55(3):434-41. doi: 10.1016/j.yhbeh.2008.12.002. Epub 2008 Dec 14. PubMed PMID: 19124024.
Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, Ikawa M, Okabe M, Ikeda T, Itohara S, Kikusui T, Mori K, Sakano H. Innate versus learned odour processing in the mouse olfactory bulb. Nature. 2007 Nov 22;450(7169):503-8. Epub 2007 Nov 7. PubMed PMID: 17989651.