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PUBLICATIONS

Weiner DJ, Ling E, Erdin S, ... , Talkowski ME, McCarroll SA, Robinson EB. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p. Nat Genet. 2022 Nov;54(11):1630-1639. doi: 10.1038/s41588-022-01203-y. https://pubmed.ncbi.nlm.nih.gov/36280734/ 

Martin J, Wray M, Agha SS, Lewis KJS, Anney RJL, O'Donovan MC, Thapar A, Langley K. Investigating Direct and Indirect Genetic Effects in Attention-Deficit/Hyperactivity Disorder Using Parent-Offspring Trios. Biol Psychiatry. 2023 Jan 1;93(1):37-44. doi: 10.1016/j.biopsych.2022.06.008. https://pubmed.ncbi.nlm.nih.gov/35933166/ 

Rajagopal VM, Duan J, Vilar-Ribó L, ... , Ribasés M, Børglum AD, Demontis D. Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder. Nat Genet. 2022 Aug;54(8):1117-1124. doi: 10.1038/s41588-022-01143-7 https://pubmed.ncbi.nlm.nih.gov/35927488/ 

Garcia-Argibay M, du Rietz E, Lu Y, Martin J, Haan E, Lehto K, Bergen SE, Lichtenstein P, Larsson H, Brikell I. The role of ADHD genetic risk in mid-to-late life somatic health conditions. Transl Psychiatry. 2022 Apr 11;12(1):152. doi: 10.1038/s41398-022-01919-9.  https://pubmed.ncbi.nlm.nih.gov/35399118/ 

Mattheisen, M., Grove, J., Als, T.D., ... Neale, B.M., Daly, M.J., Børglum, A.D. (2022). Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups. Nat Genet 2022 Oct;54(10):1470-1478. https://www.nature.com/articles/s41588-022-01171-3 

Strom, N.I., Grove, J., Meier, S.M., ... Mattheisen, M. (2021). Polygenic heterogeneity across obsessive-compulsive disorder subgroups defined by a comorbid diagnosis. Front Genet 2021 Aug 31;12:711624. https://www.frontiersin.org/articles/10.3389/fgene.2021.711624/full 

Martin, J., Asjadi, K., Hubbard, L., .... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. (2021). Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. PLoS One, 16(9): e0848254. https://doi.org/10.1371/journal.pone.0248254

Martin, J., Agha, S.S., Eyre, O., ... Psychiatric Genomics Consortium ADHD Working Group, O'Donovan, M., Thapar, A. (2021). Sex differences in anxiety and depression in children with attention deficit hyperactivity disorder: Investigating  genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 186(7): 412-422, https://doi.org/10.1002/amjb.b.32842

Warrier, V., Kwong, A.S., Luo, M., Dalvie, S.....Cecil, C.A.M. (2021). Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach. Lancet Psychiatry, 8(5): 373-386. https://doi.org/10.1016/S2215-0366(20)30569-1

Brikell,  I., Burton, C.L., Mota, R.N.,  & Martin, J. (2021). Insights into attention-deficit/hyperactivity disorder from recent genetic studies. Psychological Medicine (PGC Specific Issue), 51(13): 2274-2286. https://doi.org/10.1017/S0033291721000982

Yao, X., Glessner, J.T., Li, J., ... Li, J. (2021). Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders. Translational Psychiatry, 11(1): 69. https://doi.org/10.1038/s41398-020-01195-5

Powell, V., Martin, J., Thapar, A., Rice, F. & Anney, R.J.L. (2021). Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: a GWAS meta-analysis. Scientific Reports, 11(1):7353. https://doi.org/10.1038/s41598-021-86802-1

Yang, Z., Wu, H., Lee, P.H., .... Mattheisen, M., Smoller, J.W., & Paschou, P. (2021). Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders Along the Impulsivity-Compulsivity Spectrum. Biological Psychiatry, 90(5): 317-327. https://doi.org/10.1016/j.biopsych.2020.12.028

Vainieri, I., Martin, J., Rommel, A-S, ... Doyle, A.E., & Kuntsi, J. (2021). Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments. Psychological Medicine, Feb 3;1-9. https://doi.org/10.1017/S0033291720005218

Demontis, D., Walters, R.K., Rajagopal, V.M., ..., Neale, B., Franke, B., Faraone, S.V., & Børglum, A.D. (2021). Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. Nature Communications, 12(1):576. https://doi.org/10.1038/s41467-020-20443-2

Agnew-Blais, J.C., Belsky, D.W., Caspi, A., ... Williams, B.S., Lewis, C.M., & Aresneault, L. (2021). Polygenic Risk and the Course of Attention-Deficit/Hyperactivity Disorder From Childhood to Young Adulthood: Findings From a Nationally Representative Cohort. Journal of the American Academy of Child and Adolescent Psychiatry, 60(9): 1146-1156. https://doi.org/10.1016/j.jaac.2020.12.033

Vilar-Ribó, L., Sánchez-Mora, C., Rovira, P., .... Ramos-Quiroga, J.A., Ribasés, M., & Articas, M.S. et al. (2020).  Genetic overlap and causality between substance use disorder and attention-deficit and hyperactivity disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 186(3): 140-150. https://doi.org/10.1002/ajmg.b.32827

Cheng, S., Wen, Y., Ma, M., Zhang, L., Liu, L., Qi, X., Cheng, B., Liang, C., Li, P., Kafle, O.P., & Zhang, F. (2020). Identifying 5 common psychiatric disorders associated chemicals through integrative analysis of genome-wide association study and chemical-gene interaction datasets. Schizophrenia Bulletin, 46(5):1182-90. https://doi.org/10.1093/schbul/sbaa053

Harich, B., van der Voet, M., Klein, M., Čížek, P., Fenckova, M., Schenck, A., & Franke, B. (2020). From rare copy number variants to biological processes in ADHD. American Journal of Psychiatry, 177(9), 855-866. https://doi.org/10.1176/appi.ajp.2020.19090923

Harich, B., Klein, M., Ockeloen, C.W., van der Voet, M., Schimmel-Naber, M., de Leeuw, N., Schenck, A., & Franke, B. (2020). From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes. Journal of Child Psychology and Psychiatry, 61(5), 545-555. https://doi.org/10.1111/jcpp.13161

Byrne, E.M., Zhu, Z., Qi, T., ... M.E., Visscher, P.M., Yang, J., & Wray, N.R. (2020). Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders. Molecular Psychiatry, 26(6): 2070-2081 https://doi.org/10.1038/s41380-020-0705-9

Johnson, E.C., Demontis, D., Thorgeirsson, T.E., , … Stefánsson, K., Børglum, A.D., & Agrawal, A., (2020). A large-scale genome-wide association study meta-analysis of cannabis use disorder. Lancet Psychiatry, 7(12), 1032-1045. https://doi.org/10.1016/s2215-0366(20)30339-4

Hammerschlag, A.R., Byrne, E.M., eQTLGen Consortium, ... Bartels, M., Wray, N.R., & Middeldorp, C.M (2020). Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies. Biological Psychiatry, 88(6), 470-479. https://doi.org/10.1016/j.biopsych.2020.05.002

Klein, M., Singgih, E.L., van Rens, A., ... Schenck, A., van der Voet, M., & Franke B. (2020). Contribution of intellectual disability-related genes to ADHD risk and to locomotor activity in Drosophila.  American Journal of Psychiatry, 177(6): 526-536. http://doi.org/10.1176/appi.ajp.2019.18050599

Mota, N.R., Poelmans, G., Klein, M., ... Reif, A., Franke, B., & Arias Vásquez A. (2020). Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between attention-deficit/hyperactivity disorder and obesity measures. Neuropsychopharmacology, 45, 1188-1195.  http://doi.org/10.1038/s41386-019-0592-4

O’Connell, K.S., Shadrin, A., Smeland, O.B., ... Stefánsson, K., Djurovic, S., & Andreassen, O.A. (2020). Identification of genetic loci shared between attention-deficit/hyperactivity disorder, intelligence, and educational attainment.  Biological Psychiatry, 87(12), 1052-1062.  http://doi.org/10.1016/j.biopsych.2019.11.015

Soler Artigas, M., Sánchez-Mora, C., Rovira, P., ...,... Casas, M., Ramos-Quiroga, J.A., & Ribasés M. (2020). Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality. Molecular Psychiatry, 25, 2493-2503 http://doi.org/10.1038/s41380-018-0339-3

Klein, M., Walters, R.K., Demontis, D.,  ... Faraone, S.V., Arias-Vasquez, A., & Franke B. (2019).  Genetic Markers of ADHD-Related Variations in Intracranial Volume.  American Journal of Psychiatry. 176(3), 228-238. http://doi.org/10.1176/appi.ajp.2018.18020149

O'Connell, K.S., Shadrin, A., Bahrami, S., ... Stefánsson, K., Djurovic, S., & Andreassen, O.A. (2019). Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder.  Molecular Psychiatry, [Epub ahead of print]. http://doi.org/10.1038/s41380-019-0613-z

Burton CL, Wright L, Shan J, Xiao B, Dupuis A, Goodale T, Shaheen SM, Corfield EC, Arnold PD, Schachar RJ, Crosbie J. (2019). SWAN scale for ADHD trait-based genetic research: a validity and polygenic risk study. Journal of Child Psychology and Psychiatry, 60(9): 988-997. http://doi.org/10.1111/jcpp.13032.

Liao, C., Laporte, A.D.,  Spiegelman, D., Akçimen, F., Joober, R., Dion, P.A. & Rouleau. G.A. (2019). Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes. Nature Communications, 10(1), 4450. http://doi.org/10.1038/s41467-019-12450-9

Hegvik, T.A., Waløen, K., Pandey, S.K., Faraone, S.V., Haavik, J., Zayats, T. (2019). Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment. Molecular Psychiatry, [Epub ahead of print]. http://doi.org/10.1038/s41380-019-0540-z

Pineda-Cirera, L., Shivalikanjli, A., Cabana-Domínguez, J., ... Faraone, S.V., Cormand, B. & Fernàndez-Castillo N. (2019). Exploring genetic variation that influences brain methylation in attention-deficit/hyperactivity disorder. Translational Psychiatry, 9(1), 242. http://doi.org/10.1038/s41398-019-0574-7

Cabana-Domínguez, J., Shivalikanjli, A., Fernàndez-Castillo, N., Cormand, B. (2019). Genome-wide association meta-analysis of cocaine dependence: Shared genetics with comorbid conditions. Progress in Neuropsychopharmacology and Biological Psychiatry, 94, 109667. http://doi.org/10.1016/j.pnpbp.2019.109667

Torrico, B., Shaw, A.D., Mosca, R., ... Fullerton, J.M., Cormand, B., & Toma, C. (2019). Truncating variant burden in high-functioning autism and pleiotropic effects of LRP1 across psychiatric phenotypes. Journal of Psychiatry and Neuroscience, 44(5), 350-359. http://doi.org/10.1503/jpn.180184

Hübel, C., Gaspar, H.A., Coleman J.R.I., ... O-Reilly, Bulik, C.M., & Breen G. (2019). Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.   Nature Communication, 10, 765. http://doi.org/10.1038/s41467-019-13544-0

Zayats, T. & Neale, B.M. (2019). Recent advances in understanding of attention deficit hyperactivity disorder (ADHD): how genetics are shaping our conceptualization of this disorder. F1000Res. 8. pii: F1000 Faculty Rev-2060. http://doi.org/10.12688/f1000research.18959.1

Verhoef, E., Demontis, D., Burgess, S.,  ... Fisher, S.E., Børglum, A.D., & St Pourcain, B. (2019). Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language. Translational Psychiatry, 9(1), 35. http://doi.org/10.1038/s41398-018-0324-2

Cross-Disorder Group of the Psychiatric Genomics Consortium. (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7):1469-1482.e11. http://doi.org/10.1016/j.cell.2019.11.020

Pettersson, E., Lichtenstein, P., Larsson, H., ... & Sullivan, P.F., Posthuman, D., & Polderman, T.J.C. (2019). Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychological Medicine, 49(7):1166-1173. http://doi.org/10.1017/S0033291718002039

Du Rietz, E., Coleman, J., Glanville, K., Choi, S.W., O'Reilly, P.F., Kuntsi, J. (2018). Association of Polygenic Risk for Attention-Deficit/Hyperactivity Disorder With Co-occurring Traits and Disorders. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging, 3(7), 635-643. http://doi.org/10.1016/j.bpsc.2017.11.013

Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., ... Rosand, J., Corvin, A., & Neale, B.M. (2018).  Analysis of shared heritability in common disorders of the brain. Science. 360(6395). http://doi.org/10.1126/science.aap8757

van Hulzen, K.J.E., Scholz, C.J., Franke, B., ... Faraone SV, Arias-Vasquez A, Reif A. (2017). Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis. Biological Psychiatry, 82(9), 634-641. http://doi.org/10.1016/j.biopsych.2016.08.040 

Middeldorp, C.M., Hammerschlag, A.R., Ouwens, K.G., ... Tiemeier, H., Posthuma, D., & Boomsma, D.I. (2016).  A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts.  Journal of the American Academy of Child and Adolescent Psychiatry, 55(10), 896-905.e6. http://doi.org/10.1016/j.jaac.2016.05.025

Salatino-Oliveira, A., Wagner, F., Akutagava-Martins, G. C.,  ... Polanczyk, G.V., Rohde, L.A., & Hutz, M. H. (2016). MAP1B and NOS1 genes are associated with working memory in youths with attention-deficit/hyperactivity disorder. European Archives of Psychiatry and Clinical Neuroscience. 266: 359-366. http://doi.org/10.1007/s00406-015-0626-9

Gao, Q., Liu, L., Chen, Y., Li, H., Yang, L., Wang, Y., & Qian, Q. (2015). Synaptosome-related (SNARE) genes and their interactions contribute to the susceptibility and working memory of attention-deficit/hyperactivity disorder in males. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 57, 132–139. http://doi.org/10.1016/j.pnpbp.2014.11.001

Gao, Q., Liu, L., Li, H.-M., Tang, Y.-L., Wu, Z.-M., Chen, Y., Wang, Y-F, & Qian, Q.-J. (2015). Interactions between MAOA and SYP polymorphisms were associated with symptoms of attention-deficit/hyperactivity disorder in Chinese Han subjects. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 168B(1), 45–53. http://doi.org/10.1002/ajmg.b.32273

Klein, M., van der Voet, M., Harich, B.,  ... Arias-Vásquez, A., Franke, B., & Psychiatric Genomics Consortium ADHD Working Group. (2015). Converging evidence does not support GIT1 as an ADHD risk gene. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 168(6): 492-507. http://doi.org/10.1002/ajmg.b.32327

Richards, J. S., Hartman, C. A., Franke, B.,  ... Oosterlaan, J., Arias-Vásquez, A. & Buitelaar, J. K. (2015). Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour. European Child & Adolescent Psychiatry, 24(2), 209–217. http://doi.org/10.1007/s00787-014-0567-2

Martin, J., O’Donovan, M. C., Thapar, A., Langley, K., & Williams, N. (2015). The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry, 5, e506. http://doi.org/10.1038/tp.2015.5

Groen-Blokhuis, M. M., Middeldorp, C. M., Kan, K.-J.,  ... Psychiatric Genomics Consortium ADHD Working Group, Neale, B.M., & Boomsma, D. I. (2014). Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children. Journal of the American Academy of Child and Adolescent Psychiatry, 53(10), 1123–1129.e6. http://doi.org/10.1016/j.jaac.2014.06.014

Hart, A. B., Gamazon, E. R., Engelhardt, B. E., ... de Wit, H., Cox, N.J., & Palmer, A. A. (2014). Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. Proceedings of the National Academy of Sciences of the United States of America, 111(16), 5968–5973. http://doi.org/10.1073/pnas.1318810111

Jarick, I., Volckmar, A.-L., Pütter, C., ... Schimmelmann, B.G., Scherag, A., & Hinney, A. (2014). Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder. Molecular Psychiatry, 19(1), 115–121. http://doi.org/10.1038/mp.2012.161

Ramos-Quiroga, J.-A., Sánchez-Mora, C., Casas, M., ... Bayés, M., Cormand, B., & Ribasés, M. (2014). Genome-wide copy number variation analysis in adult attention-deficit and hyperactivity disorder. Journal of Psychiatric Research, 49, 60–67. http://doi.org/10.1016/j.jpsychires.2013.10.022

Martin, J., Cooper, M., Hamshere, M. L., ... O'Donovan, M.C., Thapar, A. & Holmans, P. (2014). Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry, 53(7), 761–770.e26. http://doi.org/10.1016/j.jaac.2014.03.004

Albayrak, Ö., Pütter, C., Volckmar, A.-L., ...  Hebebrand, J., Hinney, A., & Psychiatric GWAS Consortium: ADHD Subgroup. (2013). Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 162B(4), 295–305. http://doi.org/10.1002/ajmg.b.32144

Cross-Disorder Group of the Psychiatric Genomics Consortium (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45(9), 984–994. http://doi.org/10.1038/ng.2711

Hamshere, M. L., Langley, K., Martin, J., ... Homans, P., O'Donovan, M.C., & Thapar, A. (2013). High loading of polygenic risk for ADHD in children with comorbid aggression. The American Journal of Psychiatry, 170(8), 909–916. http://doi.org/10.1176/appi.ajp.2013.12081129

Cross-Disorder Group of the Psychiatric Genomics Consortium. (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 381(9875), 1371-1379. http://doi.org/10.1016/S0140-6736(12)62129-1 

Elia, J., Glessner, J. T., Wang, K.,  ... Nelson, S.F., Faraone, S.V., & Hakonarson, H. (2012). Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature Genetics, 44(1), 78–84. http://doi.org/10.1038/ng.1013

Stergiakouli, E., Hamshere, M., Holmans, P.,  ... Owen, M.J., O'Donovan, M., & Thapar. (2012). Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry, 169(2), 186–194. http://doi.org/10.1176/appi.ajp.2011.11040551

Hinney, A., Scherag, A., Jarick, I., ... Schimmelmann, B.G., Hebebrand, J. & Psychiatric GWAS Consortium: ADHD subgroup. (2011). Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 156B(8), 888–897. http://doi.org/10.1002/ajmg.b.31246

Mick, E., Todorov, A., Smalley, S., Hu, X., Loo, S., Todd, R. D., Faraone, S. V. (2010). Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49(9), 898–905.e3. http://doi.org/10.1016/j.jaac.2010.02.014