Welcome to PGC-ADHD

The PGC ADHD workgroup was formed in 1998 with funding from a conference grant from the National Institute of Mental Health. We have been part of the PGC since its inception. During that time, our membership has grown to include 106 investigators from 29 institutions and 14 countries. Our group focuses on the study of ADHD and associated features in children and adults.

Our interdisciplinary membership includes graduate and postdoctoral trainees in psychiatric genetics as well as distinguished faculty in psychology, psychiatry, biostatistics, bioinformatics and genetics. Working together we have documented the existence of a polygenic background that mediates the risk for ADHD (please see Select Publications section below).

To date, we have identified 12 independent genome-wide loci associated with ADHD in 20,183 individuals diagnosed with ADHD and 35,191 controls (Demontis et al., 2019) with new results from a substantially larger meta-analysis forthcoming.

Our current goals are to:

• Increase the number of ADHD cases with genome-wide genotype data to 100,000

• Expand the diversity of ancestral populations in our samples

• Extend our work into exome/genome sequencing as well as copy number variants (CNVs)