Anjum R., Clarke, V.R.J., Nagasawa, Y., Murakoshi, H., & Paradis, S. Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus. BioRxiv preprint 10.1101/2024.03.11.584540. (2024)

Adel S. S., Pranske, Z. J., Kowalski T. F., Kanzler, N., Ray, R., Carmona, C., & Paradis, S. Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation. Molecular and Cellular Neuroscience 128, 103920 (2024).

Adel, S. S., Clarke, V. R. J., Evans-Strong, A., Maguire, J. & Paradis, S. Semaphorin 4D induced inhibitory synaptogenesis decreases epileptiform activity and alters progression to Status Epilepticus in mice. Epilepsy Res 193, 107156 (2023).

Herzog, J. J., Xu, W., Deshpande, M., Rahman, R., Suib, H., Rodal, A. A., Rosbash, M. & Paradis, S. TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression. Proc Natl Acad Sci USA 117, 11760–11769 (2020).

Richards, S. E. V., Moore, A. R., Nam, A. Y., Saxena, S., Paradis, S. & Van Hooser, S. D. Experience-dependent development of dendritic arbors in mouse visual cortex. J Neurosci 40, 6536–6556 (2020).

Royer, L., Shangraw, K., Herzog, J. J., Pouvreau, S., Marr, M. T.* & Paradis, S.* The Metastasis Suppressor Protein Nme1 Is a Concentration-Dependent Modulator of Ca 2+ /Calmodulin-Dependent Protein Kinase II. Biochemistry 58, 2710–2714 (2019). *co-corresponding authors 

Acker, D., Paradis, S. & Miller, P. Stable memory and computation in randomly rewiring neural networks. Journal of Neurophysiology 122, 66–80 (2019).

Royer, L., Herzog, J. J., Kenny, K., Tzvetkova, B., Cochrane, J. C., Marr, M. T. & Paradis, S. The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity. Journal of Biological Chemistry 293, 14798–14811 (2018).

McDermott, J. E., Goldblatt, D. & Paradis, S. Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus. Mol Cell Neurosci 92, 50–66 (2018).

Moore, A. R., Richards, S. E., Kenny, K., Royer, L., Chan, U., Flavahan, K., Van Hooser, S. D.* & Paradis, S.* Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits. eLife 7, e33092 (2018). *co-corresponding authors 

Acker, D. W. M., Wong, I., Kang, M. & Paradis, S. Semaphorin 4D promotes inhibitory synapse formation and suppresses seizures in vivo. Epilepsia 59, 1257–1268 (2018).

Kenny, K., Royer, L., Moore, A. R., Chen, X., Marr, M. T. & Paradis, S. Rem2 signaling affects neuronal structure and function in part by regulation of gene expression. Mol Cell Neurosci 85, 190–201 (2017).

Herzog, J. J.*, Deshpande, M.*, Shapiro, L., Rodal, A. A. & Paradis, S. TDP-43 misexpression causes defects in dendritic growth. Sci Rep 7, 15656 (2017). *authors contributed equally

Steinmetz, C. C., Tatavarty, V., Sugino, K., Shima, Y., Joseph, A., Lin, H., Rutlin, M., Lambo, M., Hempel, C. M., Okaty, B. W., Paradis, S., Nelson, S. B. & Turrigiano, G. G. Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Cell Reports 16, 2711–2722 (2016).

Ghiretti, A. E. & Paradis, S. Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins. Trends Neurosci 37, 399–407 (2014).

Raissi, A. J., Scangarello, F. A., Hulce, K. R., Pontrello, J. K. & Paradis, S. Enhanced potency of the metalloprotease inhibitor TAPI-2 by multivalent display. Bioorg Med Chem Lett 24, 2002–2007 (2014).

Ghiretti, A. E., Moore, A. R., Brenner, R. G., Chen, L.-F., West, A. E., Lau, N. C., Van Hooser, S. D. & Paradis, S. Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo. J Neurosci 34, 392–407 (2014).

Raissi, A. J., Staudenmaier, E. K., David, S., Hu, L. & Paradis, S. Sema4D localizes to synapses and regulates GABAergic synapse development as a membrane-bound molecule in the mammalian hippocampus. Mol Cell Neurosci 57, 23–32 (2013).

Moore, A. R., Ghiretti, A. E. & Paradis, S. A Loss-Of-Function Analysis Reveals That Endogenous Rem2 Promotes Functional Glutamatergic Synapse Formation and Restricts Dendritic Complexity. PLoS ONE 8, e74751 (2013).

Zeng, M., Kuzirian, M. S., Harper, L., Paradis, S., Nakayama, T. & Lau, N. C. Organic small hairpin RNAs (OshR): A do-it-yourself platform for transgene-based gene silencing. Methods 63, 101–109 (2013).

Kuzirian, M. S., Moore, A. R., Staudenmaier, E. K., Friedel, R. H. & Paradis, S. The class 4 semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus. J Neurosci 33, 8961–8973 (2013).

• Commentary in Epilepsy Professional September 2013

• Highlighted in Science Business Exchange June 20, 2013

Ghiretti, A. E., Kenny, K., Marr, M. T. & Paradis, S. CaMKII-Dependent Phosphorylation of the GTPase Rem2 Is Required to Restrict Dendritic Complexity. Journal of Neuroscience 33, 6504–6515 (2013).

Kuzirian, M.S., & Paradis, S. 2011. Distinct and Overlapping Mechanisms of Glutamatergic and GABAergic Synapse Formation. Prog. Neurobiol., 95: 68-87. [invited review]

Ghiretti, A. E. & Paradis, S. The GTPase Rem2 regulates synapse development and dendritic morphology. Dev Neurobiol 71, 374–389 (2011).

Paradis, S. in The Sticky Synapse (eds. Umemori, H. & Hortsch, M.) 321–331 (Springer New York, 2009). doi:10.1007/978-0-387-92708-4_15 (invited book chapter)

Paradis, S.*, Harrar, D. B.*, Lin, Y., Koon, A. C., Hauser, J. L., Griffith, E. C., Zhu, L., Brass, L. F., Chen, C. & Greenberg, M. E. An RNAi-Based Approach Identifies Molecules Required for Glutamatergic and GABAergic Synapse Development. Neuron 53, 217–232 (2007). *authors contributed equally

Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C. & Greenberg, M. E. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311, 1008–1012 (2006).

Tolias, K. F., Bikoff, J. B., Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R. J. & Greenberg, M. E. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron 45, 525–538 (2005).

Paradis, S., Sweeney, S. T. & Davis, G. W. Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization. Neuron 30, 737–749 (2001).

Davis, G. W., Eaton, B. & Paradis, S. Synapse formation revisited. Nat Neurosci 4, 558–560 (2001).

Paradis, S., Ailion, M., Toker, A., Thomas, J. H. & Ruvkun, G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 13, 1438–1452 (1999).

Paradis, S. & Ruvkun, G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12, 2488–2498 (1998).

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A. & Ruvkun, G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994–999 (1997).