Research in the Paradis laboratory seeks to bridge the gap between molecular and systems neuroscience by defining the genes that instruct neurons to establish and modify their synaptic connections and dendritic morphology. Neurons convey information by making synaptic connections onto other neurons, and receive information via synaptic inputs onto their dendritic arbor. To understand how appropriate information flow occurs within neuronal networks, it is first necessary to define the genes and signaling pathways that instruct specific connections between neurons. To this end, research in the Paradis lab is roughly organized around the following main topics: