Publications
37. Large-Scale Synthesis of Man9GlcNAc2 High-Mannose Glycan and the Effect of the Glycan Core on Multivalent Recognition by HIV Antibody 2G12.
Neralkar, M.; Xu, B.; Horiya, S.; Krauss, I. J. ACS Infect. Dis. 2022, 8(11), 2232-2241. doi
36. Homoallylboration of Aldehydes: Stereoselective Synthesis of Allylic-Substituted Alkenes and E-Alkenes.
Polyak, D.; Xu, B.; Krauss, I. J. Org. Lett. 2022, 24(25), 4656–4659. doi
35. A Mechanistic Switch from Homoallylation to Cyclopropylcarbinylation of Aldehydes.
Lee, W.; Polyak, D.; Xu, B.; Houk, K. N.; Krauss, I. J. Org. Lett. 2022, 24(25), 4660–4664. doi
34. An Optimized Synthesis of Fmoc-l-Homopropargylglycine-OH.
Polyak, D.; Krauss, I. J. J. Org. Chem. Soc. 2022, 87(5), 3841–3844. doi
33. Directed Evolution of 2′-Fluoro-Modified, RNA-Supported Carbohydrate Clusters That Bind Tightly to HIV Antibody 2G12.
Redman, R. L.; Krauss, I. J. J. Am. Chem. Soc. 2021, 143(23), 8565–8571. doi
32. Synthesis of Mannosidase-Stable Man3 and Man4 Glycans Containing S-linked Manα1→2Man Termini.
Neralkar, M.; Tian, L.; Redman, R. L.; Krauss, I. J. Org. Lett. 2021, 23(8), 3053-3057. doi
31. Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase.
Matos, J. O.; Kumar, R. P.; Ma, A. C.; Patterson, M.; Krauss, I. J.; Oprian, D. D. ACS Biochem. 2020, 59(35), 3271-3283. doi
30. The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans.
Nguyen, D. N.; Redman, R. L.; Horiya, S.; Bailey, J. K.; Xu, B.; Stanfield, R. L.; Temme, J. S.; LaBranche, C. C.; Wang, S.; Rodal, A. A.; Montefiori, D. C.; Wilson, I. A.; Krauss, I. J. ACS Chem. Biol. 2020, 15(3), 789-798. doi
29. Direct Evidence of an Enzyme-Generated LPP Intermediate in (+)-Limonene Synthase Using a Fluorinated GPP Substrate Analog.
Morehouse, B. R.; Kumar, R. P.; Matos, J. O.; Yu, Q.; Bannister, A.; Malik, K.; Temme, J. S.; Krauss, I. J.; Oprian, D. D. ACS Chem. Biol. 2019, 14(9), 2035-2043. doi
28. Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.
Nguyen, D. N.; Xu, B.; Stanfield, R. L.; Bailey, J. K.; Horiya, S.; Temme, S. J.; Leon, D. R.; LaBranche, C. C.; Montefiori, D. C.; Costello, C. E.; Wilson, I. A.; Krauss, I. J. ACS Cent. Sci. 2019, 5, 237-249. doi
27. Stereoselective Homocrotylation of Aldehydes: Enantioselective Synthesis of Allylic-Substituted Z/E-Alkenes.
Tian, L; Krauss, I. J. Org. Lett. 2018, 20, 6730-6735. doi
26. Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis Using Fluorinated Substrate Analogues.
Kumar, R. P.; Morehouse, B. R.; Matos, J. O.; Malik, K.; Lin, H.; Krauss, I. J.; Oprian, D. D. Biochemistry 2018, 56, 1716-1725. doi
25. Directed Evolution of Glycopeptides Using mRNA Display.
Horiya, S; Bailey, J. K.; Krauss, I. J. Methods Enzymol. 2017, 597, 83-141. doi
24. DNA display of folded RNA libraries enabling RNA-SELEX without reverse transcription.
MacPherson, I. S.; Temme, J. S.; Krauss, I. J. Chem. Comm. 2017, 53(19), 2878-2881. doi
23. Synthesis of Multivalent Glycopeptide Conjugates that Mimic an HIV Epitope.
Bailey, J. K.; Nguyen, D. N.; Horiya, S.; Krauss, I. J. Tetrahedron 2016, 72(40), 6091-6098. doi
22. Antibody Recognition of HIV and Dengue Glycoproteins.
Krauss, I. J. Glycobiology 2016, 26(8), 813-819. doi
21. Enantioselective syn and anti Homocrotylation of Aldehydes: Application to the Formal Synthesis of Spongidepsin.
Lin, H. K.; Tian, L.; Krauss, I. J. J. Am. Chem. Soc. 2015, 137(40), 13176-13182. doi
20. SELMA: Selection with Modified Aptamers.
Temme, J. S.; Krauss I. J. Curr. Protoc. Chem. Biol. 2015, 7, 73-92. doi
19. Recent Strategies Targeting HIV Glycans in Vaccine Design.
Horiya, S.; MacPherson, I. S.; Krauss I. J. Nat. Chem. Biol. 2014, 10, 990-999. doi
18. Boron Carboxylate Catalysis of Homoallylboration.
Dugas, G. J.; Lam, Y.-H.; Houk, K. N.; Krauss, I. J. J. Org. Chem. 2014, 79(10), 4277-4284. doi. Featured article
17. Directed Evolution of Multivalent Glycopeptides Tightly Recognized by HIV Antibody 2G12.
Horiya, S.; Bailey, J. K.; Temme, S. J.; Guillen-Schlippe, Y. V.; Krauss, I. J. J. Am. Chem. Soc. 2014, 136(14), 5407-5415. doi. Highlighted in C&E News
16. High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12.
Temme, S. J.; MacPherson, I. S.; DeCourcey, J. F.; Krauss, I. J. J. Am. Chem. Soc. 2014, 136(5), 1726-1729. doi
15. Directed Evolution of 2G12-Targeted Nonamannose Glycoclusters by SELMA.
Temme, J. S.; Drzyzga, M.; MacPherson, I. S.; Krauss, I. J. Chem. - Eur. J. 2013, 19(51), 17291-17295. doi
14. Enantioselective Homocrotylboration of Aliphatic Aldehydes.
Lin, H.; Pei, W.; Wang, H.; Houk, K. N.; Krauss, I. J. J. Am. Chem. Soc. 2013, 135(1), 82-85. doi.
Highlighted in Synfacts.
Highlighted in Organic Synthesis Highlights
13. Homoallylboration and Homocrotylboration of Aldehydes.
Pei, W.; Krauss, I. J. J. Am. Chem. Soc. 2011, 133(46), 18514-18517. doi
Highlighted in Synfacts
12. Multivalent Glycocluster Design Through Directed Evolution.
MacPherson, I. S.; Temme. J. S.; Habeshian, S.; Felczak, K.; Pankiewicz, K.; Hedstrom, L.; Krauss, I. J. Angew. Chem. Int. Ed. 2011, 50(47), 11238-11242. doi
11. A Short Asymmetric Route to the Bromophycolide A and D Skeleton.
Lin, H.; Pochapsky, S.S.; Krauss, I. J. Org. Lett. 2011, 13(5), 1222-1225. doi
10. Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative.
Gao, Y.; Kuang, Y.; Guo, Z-F.; Guo, Z.; Krauss, I. J.; Xu, B. J. Am. Chem. Soc. 2009, 131(38), 13576-13577. doi
Graduate and Postdoctoral Work
9. Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims.
Nagorny, P.; Krauss, I. J.; Njardarson, J. T.; Perez, L.; Gaul, C.; Yang, G.; Ouerfelli, O.; Danishefsky, S. J. Tetrahedron Lett. 2010, 51(30), 3873-3875. doi
8. Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog.
Oskarsson, T.; Nagorny, P.; Krauss, I. J.; Perez, L.; Mandal, M.; Yang, G.; Ouerfelli, O.; Xiao, D.; Moore, M. S.; Massague, J.; Danishefskhy, S. J. J. Am. Chem. Soc. 2010, 132(9), 3224-3228. doi
7. A New Model for the Presentation of Tumor-Associated Antigens and the Quest for an Anticancer Vaccine: A Solution to the Synthesis Challenge via Ring-Closing Metathesis.
Jeon, I.; Lee, D.; Krauss, I. J.; Danishefsky, S. J. J. Am. Chem. Soc. 2009, 131(40), 14337-14344. doi
6. An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions.
Joyce, J. G.; Krauss, I. J.; Song, H. C.; Opalka, D. W.; Grimm, K. M.; Nahas, D. D.; Esser, M. T.; Hrin, R.; Feng, M.; Dudkin, V. Y.; Chastain, M.; Shiver, J. W.; Danishefsky, S. J. Proc. Natl. Acad. Sci. USA 2008, 105(41), 15684-15689. doi
5. Total Synthesis of Spirotenuipesines A and B.
Dai, M.; Krauss, I. J.; Danishefsky, S. J. J. Org. Chem. 2008, 73(24), 9576-9583. doi
4. Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody.
Krauss, I. J.; Joyce, J. G.; Finnefrock, A. C.; Song, H. C.; Dudkin, V. Y.; Geng, X.; Warren, J. D.; Chastain, M.; Shiver, J. W.; Danishefsky, S. J. J. Am. Chem. Soc. 2007, 129(36), 11042-11044. doi
3. Total synthesis of (+)-isomigrastatin.
Krauss, I. J.; Mandal, M.; Danishefsky, S. J. Angew. Chem. Int. Ed. 2007, 46(29), 5576-5579. doi
2. Highly Practical and Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature.
Krauss, I. J.; Leighton, J. L. Org. Lett. 2003, 5(18), 3201-3203. doi
1. Highly Regioselective and Diastereoselective Directed Hydroformylation of Allylic Ethers: A New Approach to Propionate Aldol Synthesis.
Krauss, I. J; Wang, C. C-Y.; Leighton, J. L. J. Am. Chem. Soc. 2000, 123(46), 11514-11515. doi