Physical Biology

of Gene Expression

Welcome to PBGX!

The main interest of our lab is to understand the physical basis underlying molecular mechanisms of gene expression.

In the same way that early astronomers discovered the laws of gravity by observing the night sky, we use single molecule fluorescence microscopy to uncover the physical principles underlying molecular motion in living cells.

Our research stands at the interface between nonequilibrium statistical mechanics and dynamical systems inside the living cell where molecular copy numbers range from 1 to 10,000, far below Avagadro's number, a condition necessary for equilibrium thermodynamics to hold sway. Join us in our explorations at the interface of physics and biology where we are trying to figure out the grammar and syntax of the book of life!

Our research is funded by:

Research Corporation for Science Advancement and the Gordon and Betty Moore Foundation through Grant GBMF5263.10

and by

National Institute of General Medical Sciences through Grant 1R15GM123446-01.