The Following Projects are Part of the Course BME 417
The Following Projects are Part of the Course BME 417
Team Members
Gordon Fuller, Pedro Gonzalez-Ochoa, Catherine Nunez, Arianna Pezzano, Justin Wilson
Our team proposes an at-home fertility diagnostic based on menstrual blood for easier and more accurate results. The diagnostic test would be paired with a fluid collecting menstrual pad and use a lateral flow assay to determine follicle-stimulating hormone levels in the blood.
Sponsor/Mentor:
Dr. Mark Wang, Sara Belko, Ravi Srekar
Women going through menopause receive Hormone Replacement Therapy (HRT), also known as menopausal hormone therapy, which is a form of therapy used to treat symptoms associated with menopause. The existing HRT is unpredictable since it is hard to control an exact dose of estrogen or progesterone and it is a burden to apply treatments daily. Thus, we propose an innovative drug delivery method providing long-acting hormone release, StableCellDelivery: a micro implant made with PLGA and estradiol/progesterone providing long controlled release of hormones.
Team Members
Zakarya Abdi, Michelle Jang, Karen Lopez, Favian Rios, Marcos Rodriguez
Sponsor/Mentor
Dr. Brent Vernon (School of Biological Health Systems Engineering at ASU), Dr. Lelan McCann (University of Arizona College of Medicine - Phoenix)
Team Members
Madison Branch, Isaac Montelongo, Brette Mullenaux, Jasmine Peterson, Devin Stealy
Sponsor/Mentor
Dr. Sarah Stabenfeldt
Our team aims to return mobility with correct physical output to patients that suffer from nerve damage due to traumatic injury (such as paraplegia/quadriplegia). The solution is an Electroconductive Nerve Scaffold consisting of a nonconductive biomaterial outer layer, an electroconductive biomaterial inner layer, an electroconductive hydrogel, and two tension clamps to assist in securing the scaffold. This permanent solution will allow for the nerves to perform all functions as usual in a protected environment and may even allow the nerve to regenerate on its own as a secondary function.
Spasmodic dysphonia is a neurological disorder that causes laryngeal muscle spasms resulting in irregular speech. We will address this clinical need by creating a long-term implantable cuff electrode for the laryngeal nerve. This device uses the concept of coordinated reset to better synchronize the firing of the neurons in the sensory loop to allow the motor cortex of the brain to correctly regulate the abductor and adductor laryngeal muscles.
Sponsor/Mentor
Dr. David Lott, MD (Mayo Clinic), Dr. Juergen Neubauer, PhD (Mayo Clinic), and Dr. Jitendran Muthuswamy, PhD (Arizona State University)
Team Members
Dhrasti Dalal, Alan Ramsey, Derek Smetanick, Ashley Tse, and Shaun Victor
Team Members
Malissa Petersen, Britney Hill, Alexis Coakley, Ariel Gravino, Santiago LeDoux
The inSEPStigator is a device focused on improving diagnosis of sepsis through decreased test turnaround times and decreased necessary sample volume. This product is a point-of-care device based on detection of biomarkers IL-6 and CRP in saliva through a gold nanoparticle-based immunoassay.
Sponsor/Mentor
Dr. J.M.R. Apollo Arquiza, Dr. Philip Efron, Dr. Aditya Shah, Dr. Marylaura Lind and Dr. Leslie Thomas
Baby Bump Technology is working to create a Non Stress Test Machine for At-Home Use to improve the quality of health care that pregnant women receive. They will be able to use the device to monitor fetal heart rate and contractions from the comfort of their own home. Physicians will be able to review the data and approve the test without taking up appointment spots.
Sponsor/Mentor
Faculty Mentor: Dr. Shaopeng Wang, Clinical Mentor: Dr. Mary-Eileen McCormack
Team Members
Jessica Camacho, Alexandra Liaos, Téa McCormack, Mariah McNally, Margie Vollkommer
Team Members
Caleb Fisher, Ashley Lopezlira, Hannah Oman, Chandler Watt, Jared Williamson
In trauma care and other hospital settings, medical professionals need to gather a rapid assessment of blood flow, especially in the palm and foot. By using the doppler shift caused by the movement of the blood, the physician can obtain audio and visual data about the state of the blood flow, which can be used to check the pulse of a patient and diagnose vascular disorders. Our Capstone project aims to develop a blood flow detection device using ultrasound technology to be more compact while maintaining its functionality.
Sponsor/Mentor
Dr. Wyatt Hoch - St. Joseph's Hospital; Dr. Mehdi Nikkhah - Arizona State University
We are improving upon existing trocar designs to adapt an otherwise unrelated surgical procedure that improves accuracy and precision. This is accomplished by adding a distal aperture to the obturator and increasing the retention threading of the outer cannula.
Sponsor/Mentor
Rosalind Sadleir, Ph.D (SBHSE), James Bogert, MD (affiliated with Dignity Health)
Team Members
Edward Chan, Keven Sepulveda, Savanna Taj, Christian Vu, Brendan Zweig
Team Members
Annika Banuelos, Benjamin Browner, Justin Maldonado, Jarrett Manalang, & Nehhaa Kathir
Our company’s goal is to create a mechanical cardiopulmonary resuscitation device that is affordable for the common family and easy to use. We hope to increase the chances of survival post-cardiac arrest by aiding the common public to perform CPR in the case of an emergency, during the time it takes emergency response services or paramedics to arrive at the scene.
Sponsor/Mentor
Christopher Plaisier, SBHSE & Hari Chaliki, Mayo Clinic
Magnetic resonance spectroscopy imaging (MRSI) is an imaging method which spatially resolves chemical signatures within tissue. MRSI currently suffers from a sensitivity to artifacts, causing data to have low confidence and be difficult to interpret. We are implementing Regularization by Artifact Removal (RARE), an approach using techniques from deep learning, to remove artifacts from MRSI spectra during the reconstruction process, in order to improve image quality and increase the clinical utility of MRSI.
Sponsor/Mentor
Dr. Benjamin Bartelle, SBHSE; Dr. Justin Kiggins, Chan Zuckerberg Initiative
Team Members
Samuel Banen, Simone Gohsman, Eriana Morgan, Connor Sanderford, Amanda Tsui
Team Members
Brooke Butler, Amanda Dionisio, Cassidy Michaels, Hannah Zaderaka
Currently, there is no standardization on the amount of tension placed on a suture when closing the abdominal fascia layer. There is a need to standardize this measurement due to the increase risk of infection caused by improper wound closure. The team will create a measurement device that can be used alongside a needle driver and will read out an accurate tension measurement reading so research can be performed based on the data collected.
Sponsor/Mentor
Dr. James Bogert, Dignity Health
Guidewires are medical-grade wires typically used to introduce, navigate, and position a catheter system within vasculature. The use of guidewires in medical procedures allow clinicians to treat and diagnose potential vessel blockages, valve problems, and heart defects. There is currently a clinical need for an improved precision-controlled guidewire system, as current solutions feature little to no precision control, the lack of access to hard-to-reach vessels, and a longer procedure time.
Sponsor/Mentor
Dr. Paul Del Prado - Creighton Medicine & Valleywise Medical Center, Dr. SungMin Sohn - ASU SBHSE
Team Members
Kylie Chung, Alexander Covaliu, Mariah Holguin, Connor Thompson, Macie Thompson
Team Members
Cameron Jeffers, Gabriella Alessio, Evan Hopkins, Keston Kajitani, Michael Skutecki
A long-lasting, secure-fitting socket with an application time of a minute or less. We are utilizing pneumatics to increase or decrease pressure to the residual limb according to the patient’s current needs. This employs a bladder system which can be retrofitted into pre-existing prosthetic sockets, allowing the patient to rapidly adjust their socket’s fit with the simple squeeze of a mechanical hand pump.
Sponsor/Mentor
Dr. Jitendran Muthuswamy, Noah Nemgar
Meniscus tears and degradation can lead to low mobility and constant pain. We are designing a new replacement hydrogel meniscus that remedies these issues.
Sponsor/Mentor
Emily Reeson from Creighton Medical & Dr. Xiaojun Tian from ASU School
Team Members
Anna Kylat, Elyana Chacon, Joe Pontrelli, Aly Sutton, Andrew Opstad
Team Members
Christina Aridi, Alyssa Labine, Aayush Shah, McKenna Strambi
In September of 2022, the FDA released a notice detailing concerns of inaccuracies in pulse oximeter devices due to darker skin pigmentation. Our team is currently developing a transmissive and reflective pulse oximeter to correct this racial bias in the measurements.
Sponsor/Mentor
Dr. Shaopeng Wang and Mayo Clinic Hospital Internal Medicine
Action and postural hand tremors related to Essential Tremor (ET) can make eating difficult, limiting food consumption and affecting patient autonomy. Current solutions are either financially inaccessible or bulky and ineffective. Utensilizer, a discrete and universal utensil handle designed to stabilize action tremors, offers an effective solution to this problem.
Sponsor/Mentor
Primary Mentor: Dr. Christopher Buneo, Technical Mentor: Dr. Sydney Schaefer, Clinical Mentor: Dr. Naomi Salins
Team Members
Lan Nguyen, Maya Eleff, Angelica Lopez, Alyssa Martinez
Team Members
Luis Canez Coronado, Paulina Cortes, Grace Bonea, Amber Mayers, Jesus Arguello
Our software is designed to process SPECT brain scan images to establish a bio maker to aid in PTSD diagnosis.
Sponsor/Mentor
Dr. Kodibagkar, Dr. Braden
A new remodel of the walker designed to mimic natural gait. This takes new aspects of different walkers, and combines them to bring back stimulation to the legs, and recentering center of mass
Sponsor/Mentor
Thurmon Lockhart, Sarah Belko
Team Members
Sikali Vidal, Ethan Spragg, Matthew Heck, Dylan Bluth, Mohammed Al-Touqi
Team Members
Hanan Alarnous, Paula Phan, Shivangi Sarkar, Wid Alsabah, Youssef Abdellatif
An innovative device that primarily focuses on the technology of thermoelectric cooling. The device consists of a head and neck piece that connect to multiple Peltier coolers that are all connected to a single power source. According to the Peliter effect, when a current is passing through the plates, the electrons from the N-type couple transfers to the P-type allows the heat from one plate to dissipate to the other plate where cooling occurs.
Sponsor/Mentor
Vincent Pizziconi
Hospital-induced delirium is a serious problem in which patients become delirious from the noisy, overstimulating environment and the consequential lack of sleep they get. Our device is a set of earbuds that aim to filter out , that contribute to this problem. Additionally it aims to track sleep patterns to help clinicians know when a patient is at risk of becoming delirious.
Sponsor/Mentor
Dr. Claire Honeycutt, SBHSE; Mayo Clinic Synapse Program
Team Members
Chim Anako, Julia Kramer, Vincent Mauri, Cole Schmidt, Keira Small
Team Members
Kyle Deacon, Mark Mcdonald, Joan Ponce Sanchez, Connor Stevens, Jessica Tenney
This is a wearable device that is being designed to stop DVT (Deep Vein Thrombosis) in the lower leg. The device is made to be mobile and utilizes the two standards of industry together in an innovative approach.
Sponsor/Mentor
Sara Belko (Thomas Jefferson University, Philadelphia, PA), Dr. Stephen Helms-Tillery (Arizona State University, School of Biological and Health Systems Engineering. Tempe, AZ)
Deuterium metabolic imaging is a new, non-invasive metabolic imaging technique that has the potential to create 3D metabolic maps more accurately and rapidly than the state-of-the-art. These maps are generated as a result of magnetic resonance spectroscopy-based measurement of the uptake and downstream metabolism of orally administered, non-radioactive, deuterium (H2)-labeled, intravenous substrate infusions. This versatile imaging method can be easily implemented into current MRI technologies in order to rival the current clinical metabolic imaging standard known as positron emission tomography and, to a much lesser extent, magnetic resonance spectroscopy/imaging.
Team Members
Trevor Bass, Connor Filbert, Christopher Boll, Daniel Bernstein, Jarek Gryskiewicz
Sponsor/Mentor
Aman Verma, DO (Mayo Clinic Synapse Program) and Dr. Beeman, SBHSE
Team Members
Gisselle Beltran Valdez, Michael C. D'Saachs, Yuliana Lopez Burboa, Jasmin Marcelino Hernandez, Makaelah Napolitano
Seyep I is a CPAP mask system that will detect and seal air leaks utilizing inflatable air bladders. These air bladders will not only stop the leak but reposition the mask as well. Additionally the system will detect when users exhale and relieve the pressure coming into the mask similar to BiPAP and APAP devices.
Sponsor/Mentor
Dr. Srekar Ravi - Mayo Clinic Arizona, Sara Belko - Thomas Jefferson University Medical College, Dr. Sung-Min Sohn - SBHSE Arizona State University
Despite the widespread need, chronic wound care remains a field in need of novel products to accelerate healing. To address this, our team is working to develop a collagen-based hydrogel impregnated with platelet-rich-plasma (PRP) capable of in situ gelation. Our mission is to reduce wound closure time and promote angiogenesis for patients by providing a simple, accessible, and personalized solution.
Sponsor/Mentor
Faculty Mentor: Dr. Sarah Stabenfeldt, ASU. Clinical Mentor: Dr. Erwin Kruger, Mayo Clinic.
Team Members
Elise Brown, Trevor Hatch, Joel Haug, Elizabeth Schmizter, Brianna Vance
Team Members
Jesus Arellano, Amir Danial Azimi, Jason Hiramine, Jacob McColm, Agustin Padilla, Peter Saupe
1 in 17,000 people suffer from Amyotrophic Lateral Sclerosis, a neuromuscular disorder the affects the upper and lower motor neuron. It is common for patients suffering from ALS to have dropped head syndrome and other symptoms that derive from muscle weakness. The severity of symptoms varies across patients and thus we are aiming to create a user-adjustable pneumatic neck brace that stabilizes the cervical spine and prevents head droop.
Sponsor/Mentor
Dr. Madeline Andrews, Dr. Shafeeq Ladha
This device was made for children who have ADHD as an aid alongside professional treatment. The CaptaEEG is a device that records and analyzes brainwaves in real time and provides visual feedback for the user to self-correct when their focus is lost. By providing active feedback, neuroplasticity is expected to occur and new focus habits will develop.
Sponsor/Mentor
Dr. Stephen Helms-Tillery
Team Members
Abyssinia Bizuneh, Makenna Colton, Atharva Shirvadekar, Michael Li, Alec Roadarmel
Team Members
Madeline Damasco, Luis Morales, Jason Warth, Shreyas Jejurkar, Swaroop Sayyaparaju
Micro extrusion 3D bioprinting is the most popular form of bioprinting and suffers from rapid losses in cell viability during printing. As team, we strive to improve bioprinter efficiency as the scientific world increasingly embraces this technology. Specifically, we aim to stabilize cell viability through multiple customizable control systems.
Sponsor/Mentor
Dr. Jose Arquiza and Dr. Jessica Weaver
We envision a future for users where prosthetics enhance daily living while remaining affordable and durable. We aim to create a modular body powered partial hand prosthetic for everyday use without the sacrifice of money or time.
Sponsor/Mentor
Sydney Schafer
Team Members
Natalia Evelyn Valenzuela, Coyan Bidwell, Nicholas Lockwood, Amory Lowe, Christopher Dunn
The Following Projects are Part of the Course BME 593
Team Members
Haley Ellis
My project was to optimize a spiral injection mold that was modeled on SolidWorks to ensure the design would have the most stable hydrogels with the highest chance of cell viability in an automated process.
Sponsor/Mentor
Jessica Weaver, Mehdi Nikkhah, Brent Vernon
Previous research has inferred neural summation when examining reaction time tasks. Such phenomenon was first described as race models, named due to the observation that two separate stimuli “race” each other to extract a response during a task, but probability models suggest less race independence. Other research has shown that electrical stimulation of the trigeminal nerve can enhance psychophysiological arousal and stress reactions. In an attempt toward understanding how neuromodulation may affect these race models and the inferred neural summation in healthy subjects, we explored the capabilities of non-invasive stimulation of the trigeminal nerve, coupled with a multimodal reaction time task. For each trial, subjects would press a button with their right index finger in response to an audio, visual, or audiovisual cue. Ten (10) subjects received transcutaneous electric nerve stimulation to the ophthalmic branch of the trigeminal nerve at 3 kHz continuously for 10 minutes. The same reaction time task was given pre and post neuromodulatory stimulation. We found a statistically significant interaction between cue modality reaction time, neuromodulated reaction time, and inferred neural summation. In summary, the results of this study indicate that there is less race model violation observed and faster reaction times observed. Neuromodulation does not appear to hinder sensory integration, but the faster responses lower the psychophysical hurdle of bimodal stimuli.
Team Members
Sean Stanek
Sponsor/Mentor
Dr. Christopher Buneo, Dr. Stephen Helms-Tillery, Dr. Justin Tanner
Team Members
Ahmed al sultani
Aims to find and test an ideal carbon dioxide sensor for a small wearable device with high sensitivity and selectivity for a fast response time.
Sponsor/Mentor
Jennifer Blain Christen, Bruce Towe, Shaopeng Wang
Deep brain stimulation (DBS) is a method of neuromodulation in which implanted electrodes produce electrical impulses for treatment of neurological disorders like Parkinson’s disease (PD). Although the efficacy of DBS as a treatment for motor control disorders is widely accepted, the metabolic mechanism of the treatment is debated among researchers. To examine the correlation between STN DBS stimulation and metabolic changes in the cortex, we analyzed blood flow and neural activity in the motor cortex of Sprague Dawley rats.
Team Members
Sonja Brett
Sponsor/Mentor
Dr. Jitendran Muthuswamy, Dr. Arati Sridharan, Dr. Bradley Greger
Team Members
Aishwarya Haradanahalli Krishna Murthy
This project is to design a behavioral paradigm to understand how perceptual difficulty and reward processing interact in the Anterior Cingulate Cortex (ACC). The design was based on a moving dot kinetogram which included reward feedback based on the weightage given to the two different attributes (direction and color).
Sponsor/Mentor
Chris Blais, Marco Santello, Christopher Buneo
Electromyography (EMG) characteristics of digit force generation during dexterous object manipulation
Sponsor/Mentor
Dr. Marco Santello, Dr. Sydney Schaefer, Yen-Hsun Wu
Team Members
Lohita Mallavarapu
Team Members
Gabriel Zdrale
My Master's Applied Project focuses on the synthesis and characterization of a novel polyurethane-based material. Specifically, the temperature-dependent swelling properties of this novel polyethylene glycol (PEG)-polypropylene glycol (PPG) polyurethane polymer are evaluated for biomedical applications.
Sponsor/Mentor
Brent Vernon, Amrita Pal, Vincent Pizziconi
With a goal of further understanding causes of falls in individuals with PD, this study aimed at characterizing gait and balance techniques amongst patients. More specifically, patients’ sway while standing still and their reactive stepping techniques were measured. Additionally, this study explored how aspects of balance and gait are affected by dual-tasking (through the performance of a visuomotor cognitive task while standing/walking).
Team Members
Kayla Zeien
Sponsor/Mentor
Dr. Hyunglae Lee (SEMTE); Dr. Sydney Shchaefer (SBHSE); Dr. Marco Santello (SBHSE)
Team Members
Emily Glagolev
Recorded force velocity and power during back squats for a group of collegiate women's lacrosse players. Force velocity curves were made for each individual. The curves were analyzed and related to sprint time.
Sponsor/Mentor
Marco Santello
Verify method of injection in the neck muscle of a pig. Ensure correct injection of the Neurostimulator device by proper visualization of the device in the pig muscle using an ultrasound handheld transducer.
Sponsor/Mentor
Dr. Jit Muthuswamy
Team Members
Meet Bharodia
Team Members
Ryan Shannon
Current research of postural and gait stability of stroke subjects is missing information on stability when going up and down slopes. This experiment is done to determine the effect an angle has on the balance of a subject when walking at their normal pace as well as a slower one.
Sponsor/Mentor
Dr. Thurmon Lockhart
Central Sensitization is hypothesized to be a major contributor to hyperreflexia after spinal cord injury. This video describes the effects of central sensitization; and how surface electromyography may be used to initiate electrical stimulation in order to prevent the development of hyperreflexia.
Team Members
Clay Stanley
Sponsor/Mentor
Stephen Helms Tillery
Team Members
Jonathan Planten
Sponsor/Mentor
Dr. Thurmon Lockhart, Dr. Christopher Buneo, Dr. Hyunglae Lee
As falls are both common and have the potential to be deadly (especially for the elderly), I set out to examine the risks of falling in various bathtub configurations. As the literature on elevation differences between the entrance floor and the base of the bathtub is scarce, I have chosen this topology to examine. Entering and exiting a bathtub/shower requires stepping over and across an obstacle (bathtub rim height) while transitioning between different floor surfaces.