Masters Applied Projects

Project 10

Curation of Neural Data from Blackrock Arrays on Patients with Epilepsy

Student:
Kevin Minh Thieu

Mentors:

Dr. Bradley Greger – SBHSE

Dr. Jeffrey Kleim – SBHSE

Dr. Jit Muthuswamy – SBHSE

YouTube Link:
View the video link below before joining the zoom meeting

Zoom link:
https://asu.zoom.us/j/6804119665

Abstract

Neural data curation is a key step in organizing raw neural data since recordings of raw neural data tend to be filled with disruptions, noise, and artifacts which will require manual identification and removal. The process for spike clustering and overall data analysis varies from procedure to procedure. As such, this project seeks to establish our methods for sorting neural data which was extracted from a Blackrock array on a patient with epilepsy. From this array, 96 channels of data were taken and analyzed using a MATLAB-based spike sorting graphical user interface called wave_clus. By altering the initial parameters and settings within the wave_clus GUI, spikes in the neural data were detected and recorded if they surpassed the desired 50 mV threshold. The program then extracted and automatically organized the spikes into clusters which will need to be analyzed manually. Each channel was then assessed to see if they contained usable data by analyzing the number of spikes, the shapes of the spikes, and the conformity of the spikes. In doing so, the data will be curated channel by channel, generating usable results by the end. The end goal of this project is to have presentable curated data alongside a procedure of how we curated said data to better aid in future endeavors with neural data curation.