Daniel Grissom, Ph.D.

Compiling Biochemical Assays onto Digital Microfluidic Biochips

Daniel Grissom, Ph.D., Jordan Ishii, Chris Hansen, Tino Madrid, Bret Arnold, J.R. Marshall

• Designed and programmed various synthesis flows to map biochemical assays, described in a high-level format, down to low-level electrode activations

• Created several software digital microfluidic simulators which encompassed synthesis and execution of biochemical assays

• Designed and fabricated a hardware simulation device (LEDs representing electrodes) to test microfluidic synthesis software

• Designed and created embedded system to connect and control real digital microfluidic device via software GUI interface

Publications/Presentations:

1. A Compiler for Cyber-physical Digital Microfluidic Biochips, C. Curtis, D. Grissom and P. Brisk, International Symposium on Code Generation and Optimization (CGO), Vienna, Austria, 2018.
2. Resource-Constrained Scheduling for Digital Microfluidic Biochips, K. O’Neal, D. Grissom and P. Brisk, ACM Journal on Emerging Tech. in Computing Systems (JETC), Vol. 14, No. 1, March, 2018.
3. Performance Improvements and Congestion Reduction for Routing-based Synthesis for Digital Microfluidic Biochips, S. Windh, C. Phung, D. Grissom, P. Pop and P. Brisk, IEEE Transactions on Computer-Aided Design (TCAD) of Integrated Circuits and Systems, 2016, Vol. 36, No. 1, January, 2017, pp. 41-54.
4. PCB Escape Routing and Layer Minimization for Digital Microfluidic Biochips, J. McDaniel, Z. Zimmerman, D. Grissom and P. Brisk, IEEE Transactions on Computer-Aided Design (TCAD) of Integrated Circuits and Systems, 2016, Vol. 36, No. 1, January, 2017, pp. 69-82.
5. An Open-source Compiler and PCB Synthesis Tool for Digital Microfluidic Biochips, D. Grissom et al., Integration: The VLSI Journal, Vol. 51, September, 2015, pp. 169-193.
6. Rapid Online Fault Recovery for Cyber-physical Digital Microfluidic Biochips, C. Jaress, P. Brisk and D. Grissom, IEEE VLSI Test Symposium (VTS), Napa, CA, 2015.
7. Performance and Cost Analysis of NoC-Inspired Virtual Topologies for Digital Microfluidic Biochips, D. Grissom and P. Brisk, International Symposium on Integrated Circuits (ISIC), Singapore, 2014.
8. A Low-Cost Field-Programmable Pin-Constrained Digital Microfluidic Biochip, D. Grissom, J. McDaniel and P. Brisk, IEEE Transactions on Computer-Aided Design (TCAD) of Integrated Circuits and Systems, Vol. 33, No. 11, October, 2014, pp. 1657-1670.
9. Multi-terminal PCB Escape Routing for Digital Microfluidic Biochips using Negotiated Congestion, J. McDaniel, D. Grissom and P. Brisk, International Conf. on Very Large Scale Integration (VLSI-SoC), Playa Del Carmen, Mexico, 2014.
10. Software Control of Cyber-physical Laboratories-on-a-Chip, 36^th Annual International conference of the IEEE Engineering in Medicine and Biology Society, Chicago, IL, USA, August 26-30, 2014 (1 page).
11. Fast Online Synthesis of Digital Microfluidic Biochips, D. Grissom and P. Brisk, IEEE Transactions on Computer-Aided Design (TCAD) of Integrated Circuits and Systems, Vol. 33, No. 3, March, 2014, pp. 356-369.
12. Exploring Speed and Energy Tradeoffs in Droplet Transport for Cyber-Physical Digital Microfluidic Biochips, J. Fiske, D. Grissom and P. Brisk, Asia & South Pacific Design Automation Conference (ASP-DAC), Singapore, 2014.
13. Interpreting Assays with Control Flow on Digital Microfluidic Biochips, D. Grissom, C. Curtis and P. Brisk, ACM Journal on Emerging Technologies (JETC) in Computing Systems, Vol. 10, No. 3, April, 2014, Article No. 24.
14. A Field-Programmable Pin-Constrained Digital Microfluidic Biochip, D. Grissom and P. Brisk, Design Automation Conference (DAC), Austin, TX, 2013.
15. A Digital Microfluidic Biochip Synthesis Framework, D. Grissom, K. O'Neal, B. Preciado, H. Patel, R. Doherty, N. Liao and P. Brisk, International Conference on Very large Scale Integration (VLSI-SoC), Santa Cruz, CA, 2012.
16. Force-directed List Scheduling for Digital Microfluidic Biochips, K. O'Neal, D. Grissom and P. Brisk, International Conference on Very large Scale Integration (VLSI-SoC), Santa Cruz, CA, 2012.
17. Fast Online Synthesis of Generally Programmable Digital Microfluidic Biochips, D. Grissom and P. Brisk, ESWEEK (CODES+ISSS), Tampere, Finland, 2012.
18. Path Scheduling on Digital Microfluidic Biochips, D. Grissom and P. Brisk, Design Automation Conference (DAC), San Francisco, CA, 2012.
19. A High-Performance Online Assay Interpreter for Digital Microfluidic Biochips, D. Grissom and P. Brisk, Great Lakes Symposium on VLSI (GLS-VLSI), Salt Lake City, UT, 2012.

Health Informatics

Daniel Grissom, Ph.D., Mario Lopez, and multiple students

• Led four (4) technical service trips (30+ students) to Namibia, Africa (2016-2019) to present prototype of electronic medical record system to Namibian Government officials

• Created and taught 8 semester-long courses advising students on project progress

• Presented lessons learned and findings in various APU forums and newsletters/publications

Publications/Presentations:

1. 2017 - APU Common Day of Learning - Namibia: A Holistic Approach to Missions & Career Calling
2. 2018 - U.S. Embassy (Windhoek, Namibia) - The Namibia Health Informatics Project
3. 2018 - The Namibia Ministry of Health and Social Services (MoHSS, Windhoek, Namibia) - The Namibia Health Informatics Project
4. 2018 - APU STEM Research Symposium - The Namibia Health Informatics Project