Blog

Immunohistochemistry for mutations?

10th December 2017

We've recently collaborated with Trevor Graham at the Barts Cancer Centre. His group, in association with ACDBio have developed a really novel methodology (called BaseScope) for identifying point mutations (i.e. KRAS codon 12) in FFPE tissue sections. This has allowed them to understand the dynamics of mutational clones, especially after chemotherapy. The paper was published this week in Nature Communications:

• Baker et al. Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution. Nature Communications 8:1998 (2017)