Publications

Roh HW*, Seo SW, Choi SH, Kim EJ, Cho SH, Kim BC, Choi JW, An YS, Kim NR, Park B, Lee SM, Moon SY, Lee D, Hong CH, Son SJ, Kim EY. Cellular circadian period and its deviation associate with Alzheimer’s pathology and brain aging in cognitively impaired older adults. PNAS. 2026 Mar - [First author]

Cho YJ, Yoon S, Kim Y, Song HM, Nam YJ, Lee SH, Lee S, Shin D, Lee SM, Moon SY, Kim EJ, Cho SH, Kim BC, Choi SH, Seo SW, Kim JC, Park YJ, Kang HY, Lee SR, Hong S, Son SJ, Hong CH, Roh HW*. Cellular senescence of patient-derived fibroblasts reveals the mid-old stage as a critical window for transcriptomic signatures linked to Alzheimer’s disease biomarkers and classification. Clin Psychopharmacol Neurosci. 2026 May - [Corresponding author]

Lee MS, Son SJ, Kim J, Go S, Hong CH, Roh HW, Chang J. Exploratory Analysis of Autophagy-Lysosomal Pathway Proteins in Dermal Fibroblasts as Potential Peripheral Biomarkers for Alzheimer's Disease: A Pilot Study. Biomedicines. 2025 Dec

Chun MY, Jung SH, Choe J, Lee SY, Kim HR, Son HJ, Choi Y, Cho M, Kim B, Jang H, Choi SH, Jeong JH, Son SJ, Hong CH, Roh HW, Na DL, Seo SW, Won HH, Seo J, Kim HJ. Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids. Alzheimers Dement. 2025 Sep

Kim Y, Nam YJ, Yoon S, Cho YJ, Song HM, Kim S, Shin D, Noh JY, Lee SM, Moon SY, Kim EJ, Cho SH, Kim BC, Choi SH, Seo SW, Choi JW, An YS, Park B, Park YJ, Kang HY, Woo HG, Cho YH, Hong S, Son SJ, Lee SR, Hong CH, Roh HW*. Transcriptional Landscape and Biomarker Discovery for Endoplasmic Reticulum Stress in Alzheimer's Disease: An Ex Vivo Study Using Patients-Derived Dermal Fibroblasts. Psychiatry Investig. 2025 Jun - [Corresponding author]

Kim H, Seo Y, Kho H, Singh SS, Lee J, Lee H, Hwang JW, Riew TR, Koh S, Choi JY, Roh HW, Son SJ, Kim GT, Cho SK, Jin HS, Jeong S, Lee KI, Lee JY, Kim BG. Novel mouse model of cerebral microbleeds by targeted Col4a1 editing in adult brain microvessels. Brain. 2026 (Accepted) 

Roh HW*, Chang YY, Kim KY, Jeon SY, Wang SM, Kim E, Bae JN, Ryu SH. Evolving Alzheimer's Disease Clinical Practice: Updated Diagnostic Criteria, Fluid Biomarkers, and Special Considerations for Anti-Amyloid Therapies. Psychiatry Investig. 2026 Feb - [First author]

Ferreira PCL, Bellaver B, Povala G, Bauer-Negrini G, Aguzzoli CS, Ferrari-Souza JP, Leffa DT, Soares C, Lussier FZ, Medeiros MS, Felix C, Ruppert E, Rohden F, Borelli WV, Karim HT, Langhough R, Christian BT, Wilson R, Hong CH, Roh HW, Patira R, Tudorascu DL, Zimmer ER, Betthauser TJ, Karikari TK, Snitz BE, Johnson SC, Son SJ, Pascoal TA. Evaluating Plasma p-tau217 as an Endpoint for Alzheimer Disease Clinical Trials. Neurology. 2026 Jan - [International Collaboration]

Chen CL, Son SJ, Schweitzer N, Jin H, Li J, Wang L, Yang S, Hong CH, Roh HW, Park B, Choi JW, An YS, Seo SW, Cho YH, Hong S, Nam YJ, Minhas DS, Laymon CM, Stetten GD, Tudorascu DL, Aizenstein HJ, Wu M; Mayo Clinic Study of Aging. Periventricular diffusivity reflects APOE ε4-modulated amyloid accumulation and cognitive impairment in the Alzheimer's disease continuum. Alzheimers Dement. 2025 Sep - [International Collaboration]

Park S, Lee DG, Kim J, Kim D, Nam Y, Park B, Kim N, Lee S, Hong CH, Son SJ, Roh HW, Woo HG, Shin H. Explainable multiplex graph propagational network with multimodal neuroimage integration for dementia subtype diagnosis. Neural Netw. 2025 Aug

Son SJ, Wu X, Roh HW, Cho YH, Hong S, Nam YJ, Hong CH, Park S. Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease. Alzheimers Res Ther. 2025 Aug

Park S, Kim D, Choi JH, Hong CH, Son SJ, Roh HW, Shin H, Woo HG. NeuroFANN: identification of neuropathological subtypes in dementia with plasma proteins by using functionally annotated neural network. Brief Bioinform. 2025 Jul

Jeon SY, Wang SM, Roh HW, Kim KY, Chang YY, Kim E, Bae JN, Ryu SH. Practical Guide of the Korean Association for Geriatric Psychiatry to Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer's Disease: Focused on Lecanemab. J Korean Med Sci. 2025 Jul 

Hong SH, Roh HW, Nam YJ, Kim TW, Cho YH, Son SJ, Hong CH. Age- and Sex-Specific Gut Microbiota Signatures Associated with Dementia-Related Brain Pathologies: An LEfSe-Based Metagenomic Study. Brain Sci. 2025 Jun

Abbas S, Ferreira PCL, Bellaver B, Povala G, Rohden F, Aguzzoli CS, Zalzale H, Ferrari-Souza JP, Leffa DT, Lussier FZ, Soares C, Bauer-Negrini G, Oliveira-Junior MS, Rodrigues MS, Saha P, Ruppert E, Medeiros MS, Tissot C, Therriault J, Rahmouni N, Servaes S, Benedet AL, Ashton NJ, Tudorascu DL, Gauthier S, Karim H, Hong CH, Roh HW, Zimmer ER, Karikari TK, Zetterberg H, Blennow K, Saeed A, Son SJ, Rosa-Neto P, Pascoal T; for Alzheimer’s Disease Neuroimaging Initiative. Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer's disease. J Prev Alzheimers Dis. 2025 Aug - [International Collaboration]

Kolobaric A, Andreescu C, Gerlach AR, Jašarević E, Aizenstein H, Pascoal TA, Ferreira PCL, Bellaver B, Hong CH, Roh HW, Cho YH, Hong S, Nam YJ, Park B, Lee DY, Kim N, Choi JW, Son SJ, Karim HT. Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults. Alzheimers Dement. 2025 Mar -[International Collaboration]

Son SJ, Lee DY, Roh HW, Ly M, Kolobaric A, Aizenstein H, Andreescu C, Jašarević E, Pascoal TA, Ferreira PCL, Bellaver B, Cho YH, Hong S, Nam YJ, Park B, Kim N, Choi JW, Cheong JY, Kim YK, Shin TS, Kang CS, Kwon CO, Yoon SY, Hong CH, Karim HT. Brain age mediates gut microbiome dysbiosis-related cognition in older adults. Alzheimers Res Ther. 2025 Feb - [International Collaboration]

Ryu JE, Shim KW, Roh HW*, Park M, Lee JH, Kim EY. Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes. Elife. 2024 Nov - [First author]

Therriault J, Janelidze S, Benedet AL, Ashton NJ, Arranz Martínez J, Gonzalez-Escalante A, Bellaver B, Alcolea D, Vrillon A, Karim H, Mielke MM, Hyung Hong C, Roh HW, Contador J, Puig Pijoan A, Algeciras-Schimnich A, Vemuri P, Graff-Radford J, Lowe VJ, Karikari TK, Jonaitis E, Brum W, Tissot C, Servaes S, Rahmouni N, Macedo AC, Stevenson J, Fernandez-Arias J, Wang YT, Woo MS, Friese MA, Jia WL, Dumurgier J, Hourregue C, Cognat E, Ferreira PL, Vitali P, Johnson S, Pascoal TA, Gauthier S, Lleó A, Paquet C, Petersen RC, Salmon D, Mattsson-Carlgren N, Palmqvist S, Stomrud E, Galasko D, Son SJ, Zetterberg H, Fortea J, Suárez-Calvet M, Jack CR Jr, Blennow K, Hansson O, Rosa-Neto P. Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability. Nat Aging. 2024 Nov - [International Collaboration]

Park S, Kim D, Lee H, Hong CH, Son SJ, Roh HW, Kim D, Nam Y, Lee DG, Shin H, Woo HG. Plasma protein-based identification of neuroimage-driven subtypes in mild cognitive impairment via protein-protein interaction aware explainable graph propagational network. Comput Biol Med. 2024 Dec

Schweitzer N, Son SJ, Thurston RC, Li J, Chen CL, Aizenstein H, Yang S, Iordanova B, Hong CH, Roh HW, Cho YH, Hong S, Nam YJ, Lee DY, Park B, Kim NR, Choi JW, Cheong J, Seo SW, An YS, Moon SY, Han SJ, Wu M. Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort. Alzheimers Res Ther. 2024 Nov - [International Collaboration]

Jang H, Chun MY, Yun J, Kim JP, Kang SH, Weiner M, Kim HJ, Na DL, Hong CH, Son SJ, Roh HW, Lee TK, Lee ES, Lee EH, Shin D, Ham H, Gu Y, Kim Y, Kim CH, Woo SY, Seo SW; ADNI, A4 study, and K-ROAD study groups. Ethnic differences in the prevalence of amyloid positivity and cognitive trajectories. Alzheimers Dement. 2024 Nov

Park S, Hong CH, Son SJ, Roh HW, Kim D, Shin H, Woo HG. Identification of molecular subtypes of dementia by using blood-proteins interaction-aware graph propagational network. Brief Bioinform. 2024 Jul

Roh HW*, Chauhan N, Seo SW, Choi SH, Kim EJ, Cho SH, Kim BC, Choi JW, An YS, Park B, Lee SM, Moon SY, Nam YJ, Hong S, Son SJ, Hong CH, Lee D. Assessing cognitive impairment and disability in older adults through the lens of whole brain white matter patterns. Alzheimers Dement. 2024 Sep - [First author]

Sleiman PM, Qu HQ, Connolly JJ, Mentch F, Pereira A, Lotufo PA, Tollman S, Choudhury A, Ramsay M, Kato N, Ozaki K, Mitsumori R, Jeon JP, Hong CH, Son SJ, Roh HW, Lee DG, Mukadam N, Foote IF, Marshall CR, Butterworth A, Prins BP, Glessner JT, Hakonarson H; Davos Alzheimer Collaborative and IHCC consortium. Trans-ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study. Alzheimers Dement. 2023 Dec - [International Collaboration]

Roh HW*, Son SJ, Hong CH, Moon SY, Lee SM, Seo SW, Choi SH, Kim EJ, Cho SH, Kim BC, Park S, Song S, An YS. Comparison of automated quantification of amyloid deposition between PMOD and Heuron. Sci Rep. 2023 Jun - [First author]

Karim HT, Aizenstein HJ, Mizuno A, Ly M, Andreescu C, Wu M, Hong CH, Roh HW, Park B, Lee H, Kim NR, Choi JW, Seo SW, Choi SH, Kim EJ, Kim BC, Cheong JY, Lee E, Lee DG, Cho YH, Moon SY, Son SJ. Independent replication of advanced brain age in mild cognitive impairment and dementia: detection of future cognitive dysfunction. Mol Psychiatry. 2022 Dec - [International Collaboration]

Roh HW*, Ryu H, Jeong S, Han J, Park B, Moon SY, Choi SH, Son SJ, Hong CH. The effectiveness of a motivational enhancement smartphone application promoting lifestyle improvement for brain health: A randomized controlled trial. PLoS One. 2022 Jun  - [First author]

Son SJ, Hong CH, Kim NR, Choi JW, Roh HW, Lee H, Seo SW, Choi SH, Kim EJ, Kim BC, Kim SY, Cheong J, Moon SY, Park B. Structural covariance changes in major cortico-basal ganglia and thalamic networks in amyloid-positive patients with white matter hyperintensities. Neurobiol Aging. 2022 Sep

Park B, Choi BJ, Lee H, Jang JH, Roh HW, Kim EY, Hong CH, Son SJ, Yoon D. Modeling Brain Volume Using Deep Learning-Based Physical Activity Features in Patients With Dementia. Front Neuroinform. 2022 Mar

Roh HW*, Kim NR, Lee DG, Cheong JY, Seo SW, Choi SH, Kim EJ, Cho SH, Kim BC, Kim SY, Kim EY, Chang J, Lee SY, Yoon D, Choi JW, An YS, Kang HY, Shin H, Park B, Son SJ, Hong CH. Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer's Disease Study: BICWALZS. Psychiatry Investig. 2022 Feb - [First author]

Cho YH, Lee H, Kim NR, Choi JW, Roh HW, Ha JH, Hong CH, Seo SW, Choi SH, Kim EJ, Kim BC, Kim SY, Cheong J, Park B, Son SJ. Cortical thickness is differently associated with ALDH2 rs671 polymorphism according to level of amyloid deposition. Sci Rep. 2021 Sep

Roh HW*, Choi JG, Kim NR, Choe YS, Choi JW, Cho SM, Seo SW, Park B, Hong CH, Yoon D, Son SJ, Kim EY. Associations of rest-activity patterns with amyloid burden, medial temporal lobe atrophy, and cognitive impairment. EBioMedicine. 2020 Aug - [First author]

Son SJ, Park B, Choi JW, Roh HW, Kim NR, Sin JE, Kim H, Lim HK, Hong CH. Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment. Front Psychiatry. 2019 Aug

Park MK, Lee JW, Lee JC, Hwang SJ, Roh HW, Hong CH, Son SJ. NLRP1 and NTN1, Deregulated Blood Differentially Methylated Regions in Mild Cognitive Impairment Patients. J Mol Neurosci. 2018 Dec

Chang KJ, Hong CH, Lee KS, Roh HW, Choi SH, Kim SY, Na DL, Seo SW, Kim DK, Kang DR, Kim J, Lee Y, Kim SH, Back JH, Chung YK, Lim KY, Noh JS, Oh BH, Son SJ. Differential effects of white matter hyperintensity on geriatric depressive symptoms according to APOE-ε4 status. J Affect Disord. 2015 Dec

Son SJ, Lee KS, Chung JH, Chang KJ, Roh HW, Kim SH, Jin T, Back JH, Kim HJ, Lee Y, Choi SH, Noh JS, Lim KY, Chung YK, Hong CH, Oh BH. Increased plasma levels of heat shock protein 70 associated with subsequent clinical conversion to mild cognitive impairment in cognitively healthy elderly. PLoS One. 2015 Mar

Kim MG, Hwang G, Chang J, Chang S, Roh HW, Park RW. Performance of Open-Source Large Language Models in Psychiatry: Usability Study Through Comparative Analysis of Non-English Records and English Translations. J Med Internet Res. 2025 Aug

Hwang G, Lee SH, Lee DY, Park C, Roh HW, Son SJ, Park RW. Age-related eye diseases and subsequent risk of mental disorders in older adults: A real-world multicenter study. J Affect Disord. 2025 Apr 

Hwang G, Park C, Son SJ, Roh HW, Hwang JY, Jang JW, Jo YT, Byeon G, Youn H, Park RW. Long-Term Impact of Delirium on the Risk of Dementia in Hospitalized Older Patients: A Real-World Multicenter Study. Am J Geriatr Psychiatry. 2025 Feb

Park S, Kim Y, Yoon S, Nam YJ, Hong S, Cho YH, Son SJ, Hong CH, Noh JS, Roh HW*. Association of Geriatric Depressive Symptoms and Government-Initiated Senior Employment Program: A Population-Based Study. Psychiatry Investig. 2024 Mar - [Corresponding author]

Yu JH, Roh HW*, Song MR, Lee JH, Haam S, Kim M. Factors in turnover intention of cardiothoracic surgery residents. Sci Rep. 2023 Nov - [First author]

Hong JW, Nam YJ, Hong S, Roh HW. Mediating effect of depressive symptoms on the relationship between digital literacy and cognitive function in older adults. Front Psychiatry. 2023 Sep - [Corresponding author]

Ko Y, Cho YH, Kim GW, Hong CH, Son SJ, Roh HW, Moon J, Han S. Relationships of walking activity with depressed mood and suicidal ideation among the middle-aged Korean population: a nationwide cross-sectional study. Front Psychiatry. 2023 Sep

Rho Y, Kim M, Beon J, Kim Y, Yoon S, Nam YJ, Hong S, Cho YH, Son SJ, Hong CH, Roh HW*. Moderators of the Association Between Contact Frequency With Non-Cohabitating Adult Children and Depressive Symptoms Among Community-Dwelling Older Adults. Psychiatry Investig. 2023 Aug - [Corresponding author]

Jang S, Choi SW, Son SJ, Oh J, Ha J, Kim WJ, Roh HW, Kim KY, Lee S, Jung E, Cha W, Chae H, Kang S, Kwon JH, Kim IY, Lee JY, Shin HK, Ryu JS, Ahn R, Hong CH, Seok JH. Virtual reality-based monitoring test for MCI: A multicenter feasibility study. Front Psychiatry. 2023 Jan

Roh HW*, Cho EJ, Son SJ, Hong CH. The moderating effect of cognitive function on the association between social support and depressive symptoms among community-dwelling older adults: Cross-sectional and longitudinal analyses. J Affect Disord. 2022 Dec - [First author]

Hwang G, Cho YH, Kim EJ, Woang JW, Hong CH, Roh HW*, Son SJ. Differential Effects of Sleep Disturbance and Malnutrition on Late-Life Depression Among Community-Dwelling Older Adults. Front Psychiatry. 2022 May - [Corresponding author]

Roh HW*, Choi SJ, Jo H, Kim D, Choi JG, Son SJ, Joo EY. Associations of actigraphy derived rest activity patterns and circadian phase with clinical symptoms and polysomnographic parameters in chronic insomnia disorders. Sci Rep. 2022 Mar - [First author]

Lee DY, Park J, Noh JS, Roh HW, Ha JH, Lee EY, Son SJ, Park RW. Characteristics of Dimensional Psychopathology in Suicidal Patients With Major Psychiatric Disorders and Its Association With the Length of Hospital Stay: Algorithm Validation Study. JMIR Ment Health. 2021 Sep

Roh HW*, Lee DE, Lee Y, Son SJ, Hong CH. Gender differences in the effect of depression and cognitive impairment on risk of falls among community-dwelling older adults. J Affect Disord. 2021 Mar - [First author]

Jang JH, Choi J, Roh HW, Son SJ, Hong CH, Kim EY, Kim TY, Yoon D. Deep Learning Approach for Imputation of Missing Values in Actigraphy Data: Algorithm Development Study. JMIR Mhealth Uhealth. 2020 Jul

Yun KS, Moon BG, Park M, Kim SJ, Shin Y, Cho SM, Noh JS, Lim KY, Chung YK, Son SJ, Roh HW*, Hong CH. Brief Screening for Four Mental Illnesses of the Elderly in Community Mental Health Services: the BS4MI-Elderly. Psychiatry Investig. 2020 May - [Corresponding author]

Roh HW*, Hong CH, Lim HK, Chang KJ, Kim H, Kim NR, Choi JW, Lee KS, Cho SM, Park B, Son SJ. A 12-week multidomain intervention for late-life depression: a community-based randomized controlled trial. J Affect Disord. 2020 Feb - [First author]

Jang M, Hong CH, Kim HC, Choi SH, Seo SW, Kim SY, Na DL, Lee Y, Chang KJ, Roh HW, Son SJ. Subcortical Ischemic Change as a Predictor of Driving Cessation in the Elderly. Psychiatry Investig. 2018 Dec

Chang KJ, Hong CH, Roh HW, Lee KS, Lee EH, Kim J, Lim HK, Son SJ. A 12-Week Multi-Domain Lifestyle Modification to Reduce Depressive Symptoms in Older Adults: A Preliminary Report. Psychiatry Investig. 2018 Mar

Chang KJ, Hong CH, Kim SH, Lee KS, Roh HW, Kang DR, Choi SH, Kim SY, Na DL, Seo SW, Kim DK, Lee Y, Chung YK, Lim KY, Noh JS, Son SJ. MRI-defined versus clinically-defined vascular depression; comparison of prediction of functional disability in the elderly. Arch Gerontol Geriatr. 2016 Sep

Roh HW*, Hong CH, Lee Y, Lee KS, Chang KJ, Kang DR, Lee JD, Choi SH, Kim SY, Na DL, Seo SW, Kim DK, Back JH, Chung YK, Lim KY, Noh JS, Son SJ. Clinical Conversion or Reversion of Mild Cognitive Impairment in Community versus Hospital Based Studies. J Alzheimers Dis. 2016 May - [First author]

Roh HW*, Hong CH, Lee S, Lee Y, Lee KS, Chang KJ, Oh BH, Choi SH, Kim SY, Back JH, Chung YK, Lim KY, Noh JS, Son SJ. Frontal Lobe Function and Risk of Hip Fracture in Patient With Alzheimer Disease: An Analysis of Linked Data. Medicine. 2015 Nov - [First author]

Roh HW*, Hong CH, Lee Y, Oh BH, Lee KS, Chang KJ, Kang DR, Kim J, Lee S, Back JH, Chung YK, Lim KY, Noh JS, Kim D, Son SJ. Participation in Physical, Social, and Religious Activity and Risk of Depression in the Elderly: A Community-Based Three-Year Longitudinal Study in Korea. PLoS One. 2015 Jul - [First author]

Chang KJ, Hong CH, Lee Y, Lee KS, Roh HW, Back JH, Jung YK, Lim KY, Noh JS, Kim HC, Choi SH, Kim SY, Na DL, Seo SW, Lee S, Son SJ. Effect of Psychotropic Drugs on Development of Diabetes Mellitus in Patients With Alzheimer's Disease. Medicine. 2015 Jun

Chang KJ, Lee S, Lee Y, Lee KS, Back JH, Jung YK, Lim KY, Noh JS, Kim HC, Roh HW, Choi SH, Kim SY, Joon Son S, Hong CH. Severity of White Matter Hyperintensities and Length of Hospital Stay in Patients with Cognitive Impairment. J Alzheimers Dis. 2015 Jun

Roh HW*, Lee Y, Lee KS, Chang KJ, Kim J, Lee SJ, Back JH, Chung YK, Lim KY, Noh JS, Son SJ, Hong CH. Frequency of contact with non-cohabitating adult children and risk of depression in elderly: a community-based three-year longitudinal study in Korea. Arch Gerontol Geriatr. 2015 Jan - [First author]

Chang KJ, Son SJ, Lee Y, Back JH, Lee KS, Lee SJ, Chung YK, Lim KY, Noh JS, Kim HC, Koh SH, Roh HW, Park MA, Kim JJ, Hong CH. Perceived sleep quality is associated with depression in a Korean elderly population. Arch Gerontol Geriatr. 2014 Sep