iNEUVA Labs 

At iNEUVA Labs, led by Hyun Woong Roh (Department of Psychiatry & Behavioral Science, Ajou University School of Medicine, WET-lab), we investigate how cellular senescence, neuroinflammation, endothelial cell damage, and neurodegeneration intersect in Alzheimer’s Disease and Vascular Neurodegeneration. 

Using patient-derived iPSCs and iPSC derived neurons, microglia, endothelial cells, and directly converted neurons, we try to build precision patient ex-vivo model to uncover the cellular mechanisms of aging and neurodegenerative disorders.

Hyun Woong Roh also manages the practical aspects of the BICWALZS cohort (PI: Chang Hyung Hong, Sub-PI: Sang Joon Son, PMID: 35042283), a large-scale study on neurodegenerative diseases, and serves as its key contact person. His work involves cohort coordination, data management, analysis, and distribution. Leveraging patient-derived cells and cohort data, iNEUVA Labs aims to elucidate the pathophysiological mechanisms of cellular senescence and neurodegeneration, advancing therapeutic target discovery for future treatment development.