Xilin Wu, Elena A B Azizan, Emily Goodchild, Sumedha Garg, Man Hagiyama, Claudia P Cabrera, Fabio L Fernandes-Rosa, Sheerazed Boulkroun , Jyn Ling Kuan, Zenia Tiang, Alessia David, Masanori Murakami, Charles A Mein, Eva Wozniak, Wanfeng Zhao, Alison Marker, Folma Buss, Rebecca S Saleeb, Jackie Salsbury, Yuta Tezuka, Fumitoshi Satoh, Kenji Oki, Aaron M Udager, Debbie L Cohen, Heather Wachtel, Peter J King, William M Drake, Mark Gurnell, Jiri Ceral, Ales Ryska, Muaatamarulain Mustangin, Yin Ping Wong, Geok Chin Tan, Miroslav Solar, Martin Reincke, William E Rainey, Roger S Foo, Yutaka Takaoka, Sandra A Murray, Maria-Christina Zennaro, Felix Beuschlein, Akihiko Ito, Morris J Brown.   Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. Nat Genet 2023 Jun;55(6):1009-1021. doi: 10.1038/s41588-023-01403-0. Epub 2023 Jun 8.

Mohan DR, Borges KS, Finco I, LaPensee CR, Rege J, Solon AL, Little DW, Else T, Almeida MQ, Dang D, Haggerty-Skeans J, Apfelbaum AA, Vinco M, Wakamatsu A, Mariani BMP, Amorim LC, Latronico AC, Mendonca BB, Zerbini MCN, Lawlor ER, Ohi R, Auchus RJ, Rainey WE, Marie SKN, Giordano TJ, Venneti S, Fragoso MCBV, Breault DT, Lerario AM, Hammer GD. β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer. Cancer Res. 2023 Jul 5;83(13):2123-2141. PMCID: PMC10330305 

Gong S, Sun N, Meyer LS, Tetti M, Koupourtidou C, Krebs S, Masserdotti G, Blum H, Rainey WE, Reincke M, Walch A, Williams TA. Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas. Hypertension. 2023 Jul;80(7):1555-1567. PMCID: PMC10330203

Rege J, Hoxie J, Liu CJ, Cash MN, Luther JM, Gellert L, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K. Targeted Mutational Analysis of Cortisol-Producing Adenomas. J Clin Endocrinol Metab. 2022 Jan 18;107(2):e594-e603.

Nanba K, Baker JE, Blinder AR, Bick N, Liu C-J, Lim JS, Wachtel H, Cohen DL, Williams TA, Reincke M, Lyden ML, Bancos I, Young WF, Else T, Giordano TJ, Udager AM, Rainey WE. Histopathology and genetic causes of primary aldosteronism in young adults. J Clin Endocrinol Metab. 2022 Jul 2;dgac408. PMID: 35779252

Nanba K, Rainey WE. Pathophysiology of bilateral hyperaldosteronism. Curr Opin Endocrinol Diabetes Obes. 2022 Jun 1;29(3):233-242.

Gomez-Sanchez CE, van Rooyen D, Rainey WE, Nanba K, Blinder AR, Baliga R. Primary aldosteronism caused by a pI157S somatic KCNJ5 mutation in a black adolescent female with aldosterone-producing adenoma. Front Endocrinol (Lausanne). 2022 Aug 16;13:921449. doi: 10.3389/fendo.2022.921449. eCollection 2022.  PMCID: PMC9424617

Gomez-Sanchez CE, Sapiro DR, May KV, Rainey WE, Nishimoto K, Gomez-Sanchez EP. Origin of circulating 18-oxocortisol in the normal human adrenal. Mol Cell Endocrinol. 2022 Sep 15;555:111720. doi: 10.1016/j.mce.2022.111720. Epub 2022 Jul 20. PMID: 35870737

Kitamura T, Blinder AR, Nanba K, Tsuiki M, Mishina M, Okuno H, Moriyoshi K, Yamazaki Y, Sasano H, Yoneyama K, Udager AM, Rainey WE, Yasoda A, Satoh-Asahara N, Tagami T. ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma. Eur J Endocrinol. 2022 Sep 1:EJE-22-0508. doi: 10.1530/EJE-22-0508. PMID: 36165744 

Ghayee HK, Xu Y, Hatch H, Brockway R, Multani AS, Gu T, Bollag WB, Turcu A, Rainey WE, Rege J, Nanba K, Bhagwandin VJ, Nwariaku F, Stastny V, Gazdar AF, Shay JW, Auchus RJ, Tevosian SG. Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis. Int J Mol Sci. 2022 Dec 29;24(1):584. doi: 10.3390/ijms24010584.  PMCID: PMC9820690

Wellman K, Fu R, Baldwin A, Rege J, Murphy E, Rainey WE, Mukherjee N. Transcriptomic Response Dynamics of Human Primary and Immortalized Adrenocortical Cells to Steroidogenic Stimuli. Cells. 2021 Sep 9;10(9):2376.

Turcu AF, Zhao L, Chen X, Yang R, Rege J, Rainey WE, Veldhuis JD, Auchus RJ. Circadian rhythms of 11-oxygenated C19 steroids and ∆5-steroid sulfates in healthy men. Eur J Endocrinol. 2021 Aug 27;185(4):K1-K6.

Nanba K, Rainey WE, Udager AM. Approaches to Gene Mutation Analysis Using Formalin-Fixed Paraffin-Embedded Adrenal Tumor Tissue From Patients With Primary Aldosteronism. Front Endocrinol (Lausanne). 2021 Jun 29;12:683588.

Mao JJ, Baker JE, Rainey WE, Young WF Jr, Bancos I. Concomitant Pheochromocytoma and Primary Aldosteronism: A Case Series and Literature Review. J Endocr Soc. 2021 Jun 16;5(8):bvab107.

Teuber JP, Nanba K, Turcu AF, Chen X, Zhao L, Else T, Auchus RJ, Rainey WE, Rege J. Intratumoral steroid profiling of adrenal cortisol-producing adenomas by liquid chromatography- mass spectrometry. J Steroid Biochem Mol Biol. 2021 Sep;212:105924.

Fu R, Wellman K, Baldwin A, Rege J, Walters K, Hirsekorn A, Riemondy K, Rainey WE, Mukherjee N. RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells. RNA. 2021 Jun 1;27(8):933-45.

Meyer LS, Handgriff L, Lim JS, Udager AM, Kinker IS, Ladurner R, Wildgruber M, Knösel T, Bidlingmaier M, Rainey WE, Reincke M, Williams TA. Single-Center Prospective Cohort Study on the Histopathology, Genotype, and Postsurgical Outcomes of Patients With Primary Aldosteronism. Hypertension. 2021 Sep;78(3):738-746.

Baker JE, Plaska SW, Qin Z, Liu CJ, Rege J, Rainey WE, Udager AM. Targeted RNA sequencing of adrenal zones using immunohistochemistry-guided capture of formalin-fixed paraffin-embedded tissue. Mol Cell Endocrinol. 2021 Jun 15;530:111296.

Nanba K, Rainey WE. GENETICS IN ENDOCRINOLOGY: Impact of race and sex on genetic causes of aldosterone-producing adenomas. Eur J Endocrinol. 2021 May 21;185(1):R1-R11.

Nanba K, Yamazaki Y, Bick N, Onodera K, Tezuka Y, Omata K, Ono Y, Blinder AR, Tomlins SA, Rainey WE, Satoh F, Sasano H.  Prevalence of somatic mutations in aldosterone-producing adenomas in Japanese. J Clin Endocrinol Metab 2020 Aug 26:dgaa595. doi: 10.1210/clinem/dgaa595. Online ahead of print. PMID: 32844168

Plaska SW, Liu CJ, Lim JS, Rege J, Bick NR, Lerario AM, Hammer GD, Giordano TJ, Else T, Tomlins SA, Rainey WE, Udager AM. Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors. Horm Metab Res. 2020 Aug;52(8):607-613. doi: 10.1055/a-1212-8803. Epub 2020 Aug 13. PMID: 32791542

Williams TA, Gomez-Sanchez CE, Rainey WE, Giordano TJ, Lam AK, Marker A, Mete O, Yamazaki Y, Zerbini MCN, Beuschlein F, Satoh F, Burrello J, Schneider H, Lenders JWM, Mulatero P, Castellano I, Knösel T, Papotti M, Saeger W, Sasano H, Reincke M. International histopathology consensus for unilateral primary aldosteronism. J Clin Endocrinol Metab. 2020 Jul 27:dgaa484. doi: 10.1210/clinem/dgaa484. Online ahead of print. PMID: 32717746

Wannachalee T, Caoili E, Nanba K, Nanba A, Rainey WE, Shields JJ, Turcu AF. The Concordance between Imaging and Adrenal Venous Sampling Varies with Aldosterone-Driver Somatic Mutation.  J Clin Endocrinol Metab. 2020 Jul 27:dgaa482. doi: 10.1210/clinem/dgaa482. Online ahead of print. PMID: 32717082

Guo Z, Nanba K, Udager A, McWhinney BC, Ungerer JPJ, Wolley M, Thuzar M, Gordon RD, Rainey WE, Stowasser M. Biochemical, Histopathological, and Genetic Characterization of Posture-Responsive and Unresponsive APAs. J Clin Endocrinol Metab. 2020 Sep 1;105(9):dgaa367. doi: 10.1210/clinem/dgaa367. PMID: 32516371

Davio A, Woolcock H, Nanba AT, Rege J, O'Day P, Ren J, Zhao L, Ebina H, Auchus R, Rainey WE, Turcu AF. Sex Differences in 11-Oxygenated Androgen Patterns Across Adulthood. J Clin Endocrinol Metab. 2020 Aug 1;105(8):dgaa343. doi: 10.1210/clinem/dgaa343. PMID: 32498089

Lim JS, Rainey WE. The Potential Role of Aldosterone-Producing Cell Clusters in Adrenal Disease. Horm Metab Res. 2020 Jun;52(6):427-434. doi: 10.1055/a-1128-0421. Epub 2020 Mar 30. PMID: 32227317

Rege J, Turcu AF, Rainey WE. Primary aldosteronism diagnostics: KCNJ5 mutations and hybrid steroid synthesis in aldosterone-producing adenomas. Gland Surg. 2020 Feb;9(1):3-13. doi: 10.21037/gs.2019.10.22. PMID: 32206594 Free PMC article. Review.

Turcu AF, Rege J, Auchus RJ, Rainey WE. 11-Oxygenated androgens in health and disease. Nat Rev Endocrinol. 2020 May;16(5):284-296. doi: 10.1038/s41574-020-0336-x. Epub 2020 Mar 16. PMID: 32203405 Review.

De Sousa K, Boulkroun S, Baron S, Nanba K, Wack M, Rainey WE, Rocha A, Giscos-Douriez I, Meatchi T, Amar L, Travers S, Fernandes-Rosa FL, Zennaro MC. Genetic, cellular, and molecular heterogeneity in adrenals with aldosterone-producing adenoma. Hypertension 75(4):1034-1044,2020 PMCID:PMC7098445  

Hattangady NG, Foster J, Lerario AM, Ponce-Balbuena D, Rege J, Monticone S, Rainey WE, Mulatero P, Else T. Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism. Horm Cancer 11(1):52-62, 2020 PMID: 32002807

Nanba K, Blinder AR, Rege J, Hattangady NG, Else T, Liu CJ, Tomlins SA, Vats P, Kumar-Sinha C, Giordano TJ, Rainey WE. Somatic CACNA1H mutation as a Cause of ldosterone-Producing adenoma. Hypertension 75(3):645-649, 2020 PMCID: PMC7059016

Ono Y, Yamazaki Y, Omata K, Else T, Tomlins SA, Rhayem Y, Williams TA, Reincke M, Carling T, Monticone S, Mulatero P, Beuschlein F, Ito S, Satoh F, Rainey WE, Sasano H. Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations. J Clin Endocrinol Metab 105(3):e282-9, 2020 PMCID: PMC7048684

Turcu AF, Wannachalee T, Tsodikov A, Nanba AT, Ren J, Shields JJ, O'Day PJ, Giacherio D, Rainey WE, Auchus RJ. Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping. Hypertension 75(1):183-192, 2020 PMCID: PMC7034384

Taylor MJ, Ullenbruch MR, Frucci EC, Rege J, Ansorge MS, Gomez-Sanchez CE, Begum S, Laufer E, Breault DT, Rainey WE. Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation. J Clin Invest 130(1):83-93, 2020 PMCID: PMC6934213

Wannachalee T, Zhao L, Nanba K, Nanba AT, Shields JJ, Rainey WE, Auchus RJ, Turcu AF. Three discrete patterns of primary aldosteronism lateralization in response to Cosyntropin during adrenal vein sampling. J Clin Endocrinol Metab 104(12):5867-5876, 2019 PMCID: PMC6800532

Rege J, Garber S, Conley AJ, Elsey RM, Turcu AF, Auchus RJ, Rainey WE. Circulating 11-oxygenated androgens across species. J Steroid Biochem Mol Biol 190:242-249, 2019 PMCID: PMC6733521  

Nanba AT, Rege J, Ren J, Auchus RJ, Rainey WE, Turcu AF. 11-Oxygenated C19 Steroids Do Not Decline With Age in Women. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2615-2622. doi: 10.1210/jc.2018-02527. PMID:30753518

Rege J, Turcu AF, Else T, Auchus RJ, Rainey WE. Steroid biomarkers in human adrenal disease. J Steroid Biochem Mol Biol. 2019 Jun;190:273-280. doi: 10.1016/j.jsbmb.2019.01.018. Epub 2019 Jan 29. Review. PMID:30707926

Nanba K, Omata K, Gomez-Sanchez CE, Stratakis CA, Demidowich AP, Suzuki M, Thompson LDR, Cohen DL, Luther JM, Gellert L, Vaidya A, Barletta JA, Else T, Giordano TJ, Tomlins SA, Rainey WE. Genetic Characteristics of Aldosterone-Producing Adenomasin Blacks. Hypertension. 2019 Apr;73(4):885-892. doi: 10.1161/HYPERTENSIONAHA.118.12070. PMID:30739536

Mohan DR, Lerario AM, Else T, Mukherjee B, Almeida MQ, Vinco M, Rege J, Mariani BMP, Zerbini MCN, Mendonca BB, Latronico AC, Marie SKN, Rainey WE, Giordano TJ, Fragoso MCBV, Hammer GD. Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma.  Clin Cancer Res 25(11):3276-3288, 2019 PMCID: PMC7117545

Nanba AT, Wannachalee T, Shields JJ, Byrd JB, Rainey WE, Auchus RJ, Turcu AF. Adrenal Vein Sampling Lateralization Despite Mineralocorticoid Receptor Antagonists Exposure in Primary Aldosteronism. J Clin Endocrinol Metab. 104(2):487-492. 2018 PMCID: PMC6316984

Rege J, Turcu A, Kasa-Vubu JZ, Lerario AM, Auchus GC, Auchus RJ, Smith JM , White PC, Rainey WE. 11-ketotestosterone is the dominantbioactive androgen during normal and premature adrenarche. J Clin Endocrinol Metab. 103:4589-4598 PMCID: PMC6226603

Nanba K, Omata K, Else T, Beck PCC, Nanba AT, Turcu AF, Miller BS, Giordano TJ, Tomlins SA, Rainey WE. Targeted MolecularCharacterization of Aldosterone-Producing Adenomas in White Americans. J Clin Endocrinol Metab. 103:3869-3876, 2018  PMCID: PMC6179168

Omata K, Satoh F, Morimoto R, Ito S, Yamazaki Y, Nakamura Y, Anand S, Guo Z, Stowasser M, Sasano H, Tomlins SA, Rainey WE. Cellular and genetic causes of idiopathic hyperaldosteronism. Hypertension, 72:874-880, 2018 PMCID: PMC6207209

Bazzell BG, Rainey WE, Auchus RJ, Zocco D, Bruttini M, Hummel SL, Byrd JB. Human Urinary mRNA as a Biomarker of Cardiovascular Disease. Circ Genom Precis Med. 2018 Sep;11:e002213  PMID:30354328

Sun N, Wu Y, Nanba K, Sbiera S, Kircher S, Kunzke T, Aichler M, Berezowska S, Reibetanz J, Rainey WE, Fassnacht M, Walch A, Kroiss M. High resolutiontissue mass spectrometry imaging reveals a refined functional anatomy of thehuman adult adrenal gland. Endocrinology. 159(3):1511-1524, 2018. PMCID:PMC5839739

Nanba K, Vaidya A, Rainey WE. Aging and adrenal aldosterone production.Hypertension. Feb;71(2):218-223, 2018.  Review. No abstract available. PMCID:PMC5839673

Rege J, Nanba AT, Auchus RJ, Ren J, Peng HM, Rainey WE, Turcu AF. Adrenocorticotropin acutely regulates pregnenolone sulfate production by the human adrenal in vivo and in vitro. J Clin Endocrinol Metab. 103(1):320-327, 2018. PMCID:PMC5761485 

Casaburi I, Avena P, De Luca A, Sirianni R, Rago V, Chimento A, Trotta F, Campana C, Rainey WE, Pezzi V. GPER-independent inhibition of adrenocortical cancer growth by G-1 involves ROS/Egr-1/BAX pathway.Oncotarget. 8(70):115609-115619, 2017.  PMCID: PMC5777797

Omata K, Tomlins SA, Rainey WE. Aldosterone-producing cell clusters in normal and pathological states. Horm Metab Res. 49(12):951-956, 2017. PMCID:PMC5770278

Shimada H, Kogure N, Noro E, Kudo M, Sugawara K, Sato I, Shimizu K, Kobayashi M, Suzuki D, Parvin R, Saito-Ito T, Uruno A, Saito-Hakoda A, Rainey WE, Ito S, Yokoyama A, Sugawara A. High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells. FEBS Open Bio. 7(9):1410-1421, 2017. PMCID:PMC5586344

Gomez-Sanchez CE, Lewis M, Nanba K, Rainey WE, Kuppusamy M, Gomez-Sanchez EP. Development of monoclonal antibodies against the human 3β-hydroxysteroid dehydrogenase/isomerase isozymes. Steroids. 127:56-61, 2017 PMCID:PMC5628156

Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Parvin R, Shimada H, Noro E, Suzuki S, Fujiwara I, Kagechika H, Rainey WE, Kure S, Ito S, Yokoyama A, Sugawara A. Suppressive effects of RXR agonist PA024 on adrenalCYP11B2 expression, aldosterone secretion and bloodpressure. PLoS One. Aug 11;12(8):e0181055 2017. PMCID:PMC5553648

Nanba AT, Nanba K, Byrd JB, Shields JJ, Giordano TJ, Miller BS, Rainey WE, Auchus RJ, Turcu AF. Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism. Clin Endocrinol 87(6):665-672, 2017 PMCID:PMC5698145

Nanba K, Vaidya A, Williams GH, Zheng I, Else T, Rainey WE Age-related autonomous aldosteronism. Circulation 136(4):347-355, 2017. PMCID:PMC5568806

Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals. Omata K, Anand SK, Hovelson DH, Liu CJ, Yamazaki Y, Nakamura Y, Ito S, Satoh F, Sasano H, Rainey WE, Tomlins SA. J Endocr Soc. 2017 May 12;1(7):787-799. PMCID:PMC5686701

Omata K, Yamazaki Y, Nakamura Y, Anand SK, Barletta JA, Sasano H, Rainey WE, Tomlins SA, Vaidya A. Genetic and Hhistopathologic inter-tumor heterogeneity in primary aldosteronism. J Clin Endocrinol Metab. 102(6):1792-1796, 2017. PMCID:PMC5470766   

Yamazaki Y, Nakamura Y, Omata K, Ise K, Tezuka Y, Ono Y, Morimoto R, Nozawa Y, Gomez-Sanchez CE, Tomlins SA, Rainey WE, Ito S, Satoh F, Sasano H. Histopathological classification of cross-sectional image negative hyperaldosteronism. J Clin Endocrinol Metab. 102:1182-1192, 2017 PMCID:PMC5460723  

Tsai YY, Rainey WE, Bollag WB. Very low-density lipoprotein (VLDL)-induced signals mediating aldosterone production. J Endocrinol. 232(2):R115-R129, 2017 Review. PMID: 27913572

Yamazaki Y, Nakamura Y, Omata K, Ise K, Tezuka Y, Ono Y, Morimoto R, Nozawa Y, Gomez-Sanchez CE, Tomlins SA, Rainey WE, Ito S, Satoh F, Sasano H. Histopathological classification of cross-sectional image negative hyperaldosteronism. J Clin Endocrinol Metab. 2016 Dec 14:jc20162986. [Epub ahead of print] PMID: 27967304

Rege J, Karashima S, Lerario AM, Smith JM, Auchus RJ, Kasa-Vubu JZ, Sasano H, Nakamura Y, White PC, Rainey WE. Age-dependent increases in adrenal cytochrome b5 andserum 5-androstenediol-3-sulfate. J Clin Endocrinol Metab. Sep 13:jc20162864. 2016 [Epub ahead of print] PMID:27623070

Taylor MJ, Sanjanwala AR, Morin EE, Rowland-Fisher E, Anderson K, Schwendeman A, Rainey WE. Synthetic high density lipoprotein (sHDL) inhibits steroid production in HAC15 adrenal cells. Endocrinology. 157(8):3122-9, 2016PMCID: PMC4967112 

Tsai YY, Rainey WE, Johnson MH, Bollag WB. VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production.Mol Cell Endocrinol. 433:138-46, 2016PMCID: PMC4955520

Nanba K, Omata K, Tomlins SA, Giordano TJ, Hammer G, Rainey WE, Else T. Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations. Eur J Endocrinol 175(2):K1-6, 2016 PMID: 27165862

Zheng S, Cherniack AD, Dewal N, Moffitt RA, Danilova L, Murray BA, Lerario AM, Else T, Knijnenburg TA, Ciriello G, Kim S, Assie G, Morozova O, Akbani R, Shih J, Hoadley KA, Choueiri TK, Waldmann J, Mete O, Robertson AG, Wu HT, Raphael BJ, Shao L, Meyerson M, Demeure MJ, Beuschlein F, Gill AJ, Sidhu SB, Almeida MQ, Fragoso MC, Cope LM, Kebebew E, Habra MA, Whitsett TG, Bussey KJ, Rainey WE, Asa SL, Bertherat J, Fassnacht M, Wheeler DA; Cancer Genome Atlas Research Network, Hammer GD, Giordano TJ, Verhaak RG. Comprehensive pan-genomic characterization of adrenocortical carcinoma. Cancer Cell. 2016 29(5):723-36, 2016PMCID: PMC4864952

Hattangady NG, Karashima S, Yuan L, Ponce-Balbuena D, Jalife J, Gomez-Sanchez CE, Auchus R, Rainey WE, Else T. Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production. J Mol Endocrinol 57(1):1-11, 2016 PMID: 27099398 

LaPensee CR, Mann JE, Rainey WE, Crudo V, Hunt SW 3rd, Hammer GD. ATR-101, a selective and potent inhibitor of Acyl-CoA acyltransferase 1, induces apoptosis in H295R adrenocortical cells and in the adrenal Cortex of Dogs. Endocrinology 157(5):1775-88, 2016 PMID:26986192

Turcu AF, Nanba AT, Chomic R, Upadhyay SK, Giordano TJ, Shields JJ, Merke DP, Rainey WE, Auchus RJ. Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency. Eur J Endocrinol 174(5):601-9, 2016 PMCID:PMC4874183 

Nanba K, Chen AX, Omata K, Vinco M, Giordano TJ, Else T, Hammer GD, Tomlins SA, Rainey WE. Molecular heterogeneity in aldosterone-producing adenomas. J Clin Endocrinol Metab 101(3):999-1007, 2016 PMCID:PMC4803171

Campana C, Rege J, Turcu A, Pezzi V, Gomez-Sanchez CE, Robins DM, Rainey WE. Development of anovel cell based androgen screening model. J Steroid Biochem Mol Biol 156:17-22, 2016 PMCID:PMC4748855

Nanba K, Chen AX, Turcu AF, Rainey WE. H295R expressionof melanocortin 2 receptor accessory protein (MRAP) results in ACTH responsiveness. J Mol Endocrinol 56(2):69-76, 2016 PMID:26576642

Chen AX, Nishimoto K, Nanba K, Rainey WE. Potassiumchannels related to primary aldosteronism: expression similarities and differences between human and rat adrenals. Mol Cell Endocrinol. 5;417:141-8, 2015 PMCID:PMC4646165

Nishimoto K, Tomlins SA, Kuick RD, Cani AK, Giordano TJ, Hovelson DH, Liu C-J, Sanjanwala AR, Edwards MA, Gomez-Sanchez CE, Nanba K and Rainey WE. Aldosterone-stimulating somatic gene mutations are common in normal adrenalglands. PNAS 18;112(33):E4591-9, 2015 PMCID:PMC4547250

Else T, Auchus RJ, Rainey WE. Exploiting the unusual to find the rare: novel steroid metabolites pinpoint adrenal cancer patients. Horm Cancer 6(4):129-30, 2015 PMID:26069029

Campana C, Pezzi V, Rainey WE.  Cell-based assays for screening androgen receptor ligands. Semin Reprod Med. 33(3):225-34, 2015 PMCID:PMC4624207

Rege J, Nishimoto KH, Nishimoto K, Rodgers RJ, Auchus RJ, Rainey WE. Bone morphogenetic protein-4 (BMP4): a paracrine regulator of human adrenal C19 steroid synthesis. Endocrinology 156(7):2530-40, 2015 PMCID:PMC4475723

Turcu AF, Rege J, Chomic R, Liu J, Nishimoto HK, Else T, Moraitis AG, Palapattu GS, Rainey WE, Auchus RJ. Profiles of 21-carbon steroids in 21-hydroxylase deficiency. J Clin Endocrinol Metab 4(4):1369-81, 2015 PMCID:PMC4454804

Satoh F, Morimoto R, Ono Y, Iwakura Y, Omata K, Kudo M, Takase K, Seiji K, Sasamoto H, Honma S, Okuyama M, Yamashita K, Gomez-Sanchez CE, Rainey WE, Arai Y, Sasano H, Nakamura Y, Ito S. Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism. Hypertension 65:1096-102, 2015 PMID:25776074

Recarti C, Seccia TM, Caroccia B, Gonzales-Campos A, Ceolotto G, Lenzini L, Petrelli L, Belloni AS, Rainey WE, Nussberger J, Rossi GP. Expression and functional role of the prorenin receptor in the human adrenocortical zona glomerulosa and in primary aldosteronism. J Hypertens 33(5):1014-22, 2015 PMID:25668351

Nanba K, Chen A, Nishimoto K, Rainey WE. Role of Ca2+/calmodulin-dependent protein kinase kinase in adrenal aldosterone production. Endocrinology 156:1750-6, 2015 PMCID:PMC4398758

Lenzini, L, Caroccia B, Campos AG, Fassina, A, Belloni AS, Seccia TM, Kuppusamy M, Ferraro S, Skander G, Bader M, Rainey WE, Rossi, GP. Lower expression of the TWIK-related acid-sensitive K+ channel 2 (TASK-2) gene is a hallmark of aldosterone-producing adenoma causing human primary aldosteronism. J Clin Endocrinol Metab 99:E674-82, 2014 PMID:24285684

Turcu A, Smith JM, Auchus R, Rainey WE. Adrenal androgens and androgen precursors---definition, synthesis, regulation and physiologic Actions. Comprehensive Physiology 4:1369-81, 2014 PMCID:PMC4437668

Matsuda K, Uruno A, Yokoyama A, Kogure N, Ito R, Sugawara K, Takako SI, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T, Satoh F, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A. Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells. Mol Cell Endocrinol 383:60-8, 2014 PMID:24333837

Felizola SJ, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, Ise K, Takase K, Sugawara A, Hattangady N, Rainey WE, Satoh F, Sasano H. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. J Mol Endocrinol 52:159-67, 2014 PMCID:PMC4103644

Nishimoto K, Harris RB, Rainey WE, Seki T. Sodium deficiency regulates rat adrenal zona glomerulosa gene expression. Endocrinology 155:1363-72, 2014 PMCID:PMC3959598

Nakamura Y, Hattangady NG, Ye P, Satoh F, Morimoto R, Ito-Saito T, Sugawara A, Ohba K, Takahashi K, Rainey WE, Sasano H. Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA). Mol Cell Endocrinol 384:102-8, 2014 PMCID:PMC4242414

Rege J, Nakamura Y, Wang T, Merchen TD, Sasano H, Rainey WE. Transcriptome profiling reveals differentially expressed transcripts between the human adrenal zona fasciculata and zona reticularis. J Clin Endocrinol Metab. 99:E518-27, 2014 PMCID:PMC3942232

Gomez-Sanchez CE, Qi X, Velarde-Miranda C, Plonczynski MW, Parker CR, Rainey W, Satoh F, Maekawa T, Nakamura Y, Sasano H, Gomez-Sanchez EP. Development of monoclonal antibodies against human CYP11B1 and CYP11B2. Mol Cell Endocrinol 383:111-7, 2014 PMCID:PMC3939805

Nakamura Y, Maekawa T, Felizola SJ, Satoh F, Qi X, Velarde-Miranda C, Plonczynski MW, Ise K, Kikuchi K, Rainey WE, Gomez-Sanchez EP, Gomez-Sanchez CE, Sasano H. Adrenal CYP11B1/2 expression in primary aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies. Mol Cell Endocrinol 392:73-79, 2014 PMCID:PMC24837548

Nakamura Y, Fujishima F, Hui XG, Felizola SJ, Shibahara Y, Akahira JI, McNamara KM,Rainey WE, Sasano H. 3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging. Endocr Res. May 15:1-6, 2014 PMCID:PMC5471353

Tsai YY, Rainey W, Pan ZQ, Frohman MA, Choudhary V, Bollag WB. Phospholipase D activity underlies very low density lipoprotein (VLDL)-induced aldosterone Production in adrenal glomerulosa Cells. Endocrinology 155:3550-60, 2014 PMID:24956203

Monticone S, Else T, Mulatero P, Williams TA, Rainey WE. Understanding primary aldosteronism: impact of next generation sequencing and expression profiling. Mol Cell Endocrinol 399C:311-320, 2014 PMID:25240470

Felizola SJ, Nakamura Y, Arata Y, Ise K, Satoh F, Rainey WE, Midorikawa S, Suzuki S, Sasano H. Metallothionein-3 (MT-3) in the Human Adrenal Cortex and its Disorders. Endocr Pathol. 25:229-35, 2014 PMID:24242700

Rege J, Nakamura Y, Wang T, Merchen TD, Sasano H, Rainey WE. Transcriptome profiling reveals differentially expressed transcripts between the human adrenal zona fasciculata and zona reticularis. J Clin Endocrinol Metab 99:E518-27, 2013 PMCID: PMC3942232

Moraitis AG, Rainey WE, Auchus RJ Gene mutations that promote adrenal aldosterone production, sodium retention, and hypertension. Appl Clin Genet. Dec 24;7:1-13, 2013 PMCID:PMC3882136

Monticone S, Hattangady NG, Penton D, ISales C, Edwards MA, Williams MA, Williams TA, Sterner C, Warth R, Mulatero P, Rainey WE. A novel Y152 KCNJ5 mutation responsible for familial hyperaldosteronism type III. J Clin Endocrinol Metab 98:E1861-5, 2013 PMCID:PMC3816265

Swart AC, Schloms L, Storbeck KH, Bloem LM, Toit TD, Quanson JL, Rainey WE, Swart P. 11 β-Hydroxyandrostenedione; the product of androstenedione metabolism in the adrenal; is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione. J Steroid Biochem Mol Biol 138:132-42, 2013 PMID 23685396

Rege J, Nakamura Y, Satoh F, Morimoto R, Kennedy MR, Layman LC, Honma S, Sasano H, Rainey WE. Liquidchromatography-tandem mass spectrometry analysis of human adrenal vein19-carbon steroids before and after ACTH stimulation. J Clin Endocrinol Metab 98(3): 1182-8, 2013 PMCID: PMC3590473

Felizola SJ, Nakamura Y, Hui XG, Satoh F, Morimoto R, M McNamara K, Midorikawa S, Suzuki S, Rainey WE, Sasano H. Estrogen-related receptor α in normal adrenal cortex and adrenocortical tumors: Involvement in development and onganogenesis. Mol Cell Endocrinol 365: 207-11, 2013 PMCID:PMC4097865

Mulatero P, Monticone S, Rainey WE, Veglio F, William TA. Role of KCNJ5 in familial and sporadic primary aldosteronism. Nat Rev Endocrinol 9:104-12, 2013 PMID 23229280

Nishimoto K, Rainey WE, Bollag WB, Seki T. Lessons from the gene expression pattern of the rat zona glomerulosa. Mol Cell Endocrinol 371:107-13, 2013 PMCID:PMC3625490

de Chantemèle EJ, Ali MI, Mintz JD, Rainey WE, Tremblay ML, Fulton DJ, Stepp DW. Increasing peripheral insulin sensitivity by protein tyrosine phosphatase 1B deletion improves control of blood pressure in obesity. Hypertension 60:1273-9, 2012 PMCID:PMC3475734

Monticone S, Auchus RJ, Rainey WE. Adrenal disorders in pregnancy. Nat Rev Endocrinol 8:668-78, 2012 PMID 22965163

Rege J, Rainey WE. The steroid metabolome of adrenarche. J Endocrinol 214:778-78, 2012 PMCID:PMC4041616

Monticone S, Hattangady NG, Nishimoto K, Mantero F, Rubin B, Cicala MV, Pezzani R, Auchus RJ, Ghayee HK, Shibata H, Kurihara I, Williams TA, Giri JG, Bollag RJ, Edwards MA, Isales CM, Rainey WE. Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells .J Clin Endocrinol Metab 97:E1567-72, 2012 PMCID:PMC3410264

Nishimoto K, Rigsby CS, Wang T, Mukai K, Gomez-Sanchez CE, Rainey WE, Seki T. Transcriptome analysis reveals differentially expressed transcripts in rat adrenal zona glomerulosa and zona fasciculata. Endocrinology 153:1755-63, 2012 PMCID:PMC3320243

Northcott CA, Fink GD, Garver H, Haywood JR, Laimon-Thomson EL, McClain JL, Pires PW, Rainey WE, Rigsby CS, Dorrance AM. The development of hypertension and hyperaldosteronism in a rodent model of life-long obesity. Endocrinology 153:1764-73, 2012 PMCID: PMC3320259

Xing Y, Rainey WE, Apolzan JW, Francone OL, Harris RBS, Bollag WB. Adrenal cell aldosterone production is stimulated by very low density lipoprotein (VLDL). Endocrinology 153: 721-731, 2012 PMCID:PMC3275386

Nakamura Y, Rege J, Satoh F, Morimoto R, Kennedy MR, Ahlem CN, Honma S, Sasano H, Rainey WE. Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein corticosteroids before and after ACTH stimulation. Clin Endocrinol 76:778-84, 2012 PMCID:PMC4266525

Wang T, Rowland JG, Parmer J, Nesterova M, Seki T, Rainey WE. Comparison of aldosterone production among human adrenocortical cell lines. Horm Metab Res 43:1-6, 2012 PMCID:PMC4269336

Wang T, Rainey WE. Human adrenocortical carcinoma cell lines. Mol Cell Endocrinol 351:58-65, 2012 PMID:22266826

Hattangady N, Olala L, Bollag WB, Rainey WE. Acute and chronic regulation of aldosterone production. Mol Cell Endocrinol 350:151-62, 2012 PMCID PMC3253327

Ghayee HK, Rege J, Watumull LM, Nwariaku FE, Carrick KS, Rainey WE, Miller WL, Auchus RJ. Clinical, biochemical, and molecular characterization of macronodular adrenocortical hyperplasia of the zona reticularis: A new syndrome. J Clin Endocrinol Metab 96:37-49, 2011 PMCID: PMC3048321

Nakamura Y, Xing Y, Hui XG, Kurotaki Y, Ono K, Cohen T, Sasano H, Rainey WE. Human adrenal cells that express both 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production. J Steroid Biochem Mol Biol 123:122-126, 2011 PMCID:PMC4269365

Uruno A, Matsuda K, Noguchi N, Yoshikawa T, Kudo M, Satoh F, Rainey WE, Hui XG, Akahira JI, Nakamura Y, Sasano H, Okamoto H, Ito S, Sugawara A. Peroxisome proliferator-activated receptor-g suppresses CYP11B2 expression and aldosterone production. J Mol Endocrinol 46:37-49, 2011 PMID 21106862

Xing Y, Cohen A, Rothblat G, Sankaranarayanan S, Weibel G, Royer L, Francone OL, Rainey WE. Aldosterone production in human adrenocortical cells is stimulated by high density lipoprotein 2 (HDL2) through increased expression of aldosteronesynthase (CYP11B2). Endocrinology 152:751-63, 2011 PMCID:PMC3040046

Habibi J, Demarco VG, Ma L, Pulakat L, Rainey WE, Whaley-Connell AT, Sowers JR. Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in transgenic modelof RAAS overexpression. Am J Physiol Heart Circ Physiol 300:HI1484-91, 2011 PMCID:PMC3075026

Wang T, Satoh F, Morimoto R, Nakamura Y, Sasano H, Auchus R, Edwards MA, Rainey W. Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands. Eur J Endocrinol 164:613-619, 2011 PMCID:PMC3741645

Mansfield CW, Carr BR, Faye-Petersen OM, Chen D, Xing Y, Rainey WE, Parker CR Jr. Differential gene expression in the adrenals of normal andanencephalic fetuses and studies focused on the fras-1 related extracellula rmatrix protein (FREM2) gene. Reproductive Sciences 18:1146-53, 2011 PMCID:PMC3343145

Hatzirodos N, Bayne RA, Irving-Rodgers HF, Hummitzsch K, Sabatier L, Lee S, Bonner W, Gibson MA, Rainey WE, Carr BR, Mason HD, Reinhardt DP, Anderson RA, Rodgers RJ. Linkage of regulators of TGFb activity in the fetal ovary to polycystic ovary syndrome. FASEB J 25:2256-65, 2011 PMCID:PMC3219214

Xing Y, Edwards MA, Ahlem C, Kennedy M, Cohen A, Gomez-Sanchez CE, Rainey WE. The effects of ACTH on steroid metabolomic profiles in human adrenal cells. J Endocrinol 209:327-35, 2011 PMCID:PMC3774117

Suda N, Shibata H, Kurihara I, Ikeda Y, Kobayashi S, Yokota K, Murai-Takeda A, Nakagawa K, Oya M, Murai M, Rainey WE, Saruta T, Itoh H. Coactivation of SF-1-mediated transcription of steroidogenic enzymesby Ubc9 and PIAS1. Endocrinology 152:2266-77, 2011 PMCID: PMC3100613

Belin de Chantemèle EJ, Mintz JD, Rainey WE, Stepp DW. Impact of leptin-mediated sympatho-activation on cardiovascular function in obese mice. Hypertension 58:271-9, 2011 PMCID: PMC3141100

Nakamura Y, Satoh F, Morimoto R, Kudo M, Takase K, Gomez-Sanchez CE, Honma S, Okuyama M, Yamashita K, Rainey WE, Sasano H, Ito S. 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism. J Clin Endocrinol Metab 96:E1272-8, 2011 PMCID: PMC5393430

Nogueira E, Gerry D, Mantero F, Mariniello B, Rainey WE. The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas. Clin Endocrinol 73:22-9, 2010 PMCID:PMC4158746

Nogueira EF, Rainey WE. Regulation of Aldosterone synthase by activator transcription factor/cAMP response element-binding protein family members. Endocrinology 151:1060-70, 2010 PMCID:PMC2840695

Xing Y, Parker CR, Edward M, Rainey WE. Adrenocorticotrophic hormone is a potent regulator of gene expression in human adrenal cells. J Mol Endocrinol 45:59-68, 2010 PMCID:PMC3725639

Sirianni R, Nogueira E, Bassett MH, Carr BR, Suzuki T, Pezzi V, Andò S, Rainey WE. The AP-1 family member FOS blocks transcriptional activity of the nuclear receptor steroidogenic factor 1. J Cell Sci 123:3956-65, 2010 PMCID:PMC2972275