Representative Publications

Aldosterone and cardiac hypertrophy: Effects of eplerenone on left ventricular function and hypertrophic remodeling in left ventricular pressure overload. Hasan F, Weinberg EO, Delyani J, Frierdich G, Converso K, Douglas PS, Lorell BH. Circulation, 1999:100; 1-565. 14. Collaboration with David Silverman at University of Connecticut: Improvement in LV Systolic Function after Cardioversion is Related to Recovery of Atrial Mechanical Function; Abstract Poster Presentations Laennec Society.

Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition. Linder AE, Weber DS, Whitesall SE, D'Alecy LG, Webb RC. J Cardiovasc Pharmacol. 2005 Oct; 46(4):438-44.

Cardiac-directed parvalbumin transgene expression in mice shows marked heart rate dependence of delayed Ca2+ buffering action. Day SM, Coutu P, Wang W, Herron T, Turner I, Shillingford M, Lacross NC, Converso KL, Piao L, Li J, Lopatin AN, Metzger JM. Physiological genomics 2008;33(3):312-22. Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0644, USA.

Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade. Michele DE, Gomez CA, Hong KE, Westfall MV, Metzger JM. Circ Res. 2002 Aug 9;91(3):255-62.

Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods.Whitesall SE, Hoff JB, Vollmer AP, D'Alecy LG. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2408-15.

Direct monitoring pressure overload predicts cardiac hypertrophy in mice. Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Mortensen RM. Physiol Meas. 2007 Nov; 28(11):1329-39.

Dystrophic heart failure blocked by membrane sealant poloxamer. Yasuda S, Townsend D, Michele DE, Favre EG, Day SM, Metzger JM. Nature. 2005 Aug 18;436(7053):1025-9.

Echocardiographic assessment of age-associated changes in systolic and diastolic function of the female F344 rat heart. Boluyt MO, Converso K, Hwang H, Mikkor A, Russell MW. Appl Physiol 2003 Oct 10. Division of Kinesiology, Laboratory of Molecular Kinesiology, The University of Michigan, Ann Arbor, MI, USA 2 Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, The University of Michigan, Ann Arbor, MI, USA.

Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes. Kellogg AP, Converso K, Wiggin T, Stevens M, Pop-Busui R. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H453-61.

Effects of hawthorn on cardiac remodeling and left ventricular dysfunction after 1 month of pressure overload-induced cardiac hypertrophy in rats. Hwang H, Bleske B, Ghannam M, Converso K, Russell M, Hunter J, Boluyt M. J Appl Physiol. 2002 Jan;92(1):288-96 Division of Kinesiology, Laboratory of Molecular Kinesiology, University of Michigan, Ann Arbor, MI, USA.

Effects of hawthorn on the progression of heart failure in a rat model of aortic constriction. Hwang HS, Boluyt MO, Converso K, Russell MW, Bleske BE. Pharmacotherapy 2009;29(6):639-48. Division of Kinesiology, Laboratory of Molecular Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.

Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosinemediated chronotropic effects. Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR. Circ Res. 2006 Mar 17; 98(5):659-66.

Flow-dependent expression of ectonucleotide tri(di) phosphohydrolase-1 and suppression of atherosclerosis. Kanthi Y, Hyman MC, Liao H, Baek AE, Visovatti SH, Sutton NR, Goonewardena SN, Neral MK, Jo H, Pinsky DJ. J Clin Invest. 2015.

Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, La Cross NC, D'Alecy LG, Ingwall JS, Metzger JM. Nat Med. 2006 Feb; 12(2):181-9.

Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Nichols R, Demers LA, Larsen BM, Robinson D, Converso K, Russell MW, Westfall MV. Peptides. 2010 Nov;31(11):2067-74.

Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC 3rd, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM. J Clin Invest. 2007 Mar; 117(3):812-22.

In vivo, Pikfyve generates PI(3.5)P₂, which serves as both a signaling lipid and the major precursor for PI5P. Zolov SN, Bridges D, Yanling Z, Lee W, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weirde T, Albin RL, Saltiel, AR, Meisler MH, Russell MW, Weisman LS. Proc Natl Acad Sci USA. 2012; 109(43):17472-17477.

Left ventricular hypertrophy worsens doxorubicin-induced cardiac toxicity. Weinberg EO, Converso K, Hasan F, Yan X, Schoen FJ, Douglas PS, Lorell BH. Circulation;1999:100; 1-117.

Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells. Min JY, Yang Y, Sullivan MF, Ke Q, Converso KL, Chen Y, Morgan JP, Xiao YF. The Journal of thoracic and cardiovascular surgery 2003;125(2):361-9. Stem Cell Research Laboratory, The Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes. Kasahara H, Ueyama T, Wakimoto H, Liu MK, Maguire CT, Converso KL, Kang PM, Manning WJ, Lawitts J, Paul DL, Berul CI, Izumo S. Journal of molecular and cellular cardiology 2003;35(3):243-56. Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, SL201, Boston, MA 02215, USA.

Non-DNA binding mutant of Csx/Nkx2.5 homeobox protein causes atrioventricular conduction abnormalities and heart failure. Kasahara H ,Wakimoto H, Converso LK, Maguire CT, Vargas MM, Usheva A, Horikoshi N, Lawitts J, Berul CI, Izumo S. Circulation 2000;102:II-35.

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein. Kasahara H, Wakimoto H, Liu M, Maguire CT, Converso KL, Shioi T, Huang WY, Manning WJ, Paul D, Lawitts J, Berul CI, Izumo S. J Clin Invest. 2001 July 15; 108(2): 189–201.

Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice. Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ, Izumo S. Circulation 2003;107:1664. From the Cardiovascular Division, Department of Medicine (T.S., J.R.M., O.T., K.C., W.J.M., S.I.) and Department of Radiology (K.C., W.J.M.), Beth Israel Deaconess Medical Center, and the Department of Cardiology (M.C.S.), Boston Children's Hospital, Boston, Mass.

Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction. Palpant NJ, Day SM, Herron TJ, Converso KL, Metzger JM. Cardiovascular research 2008;80(2):209-18. Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1301 E. Catherine Street, 7727 Medical Science II, Ann Arbor, MI 48109-0622, USA.

Transplantation of embryonic stem cells Improves cardiac function in postinracted rats. Min JY, Yang Y, Liu L, Converso KL, Morgan JP, Xiao YF. Journal of Applied Physiology 2002;92: 288-296.

Vascular dysfunction in the alpha-galactosidase A-knockout mouse is an endothelial cell plasma membrane-based defect. Park JL, Whitesall SE, D'Alecy LG, Shu L, Shayman JA. Clin Exp Pharmacol Physiol. 2008 Oct; 35(10):1156-63.

Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension. Chang L, Villacorta L, Zhang J, Garcia-Barrio MT, Yang K, Hamblin M, Whitesall SE, D'Alecy LG, Chen YE. Circulation. 2009 Apr 28; 119(16):2161-9.