Physiology Phenotyping Core

The Physiology Phenotyping Core (PPC) provides state of the art phenotyping services for animal models ranging from zebrafish all the way to large animals, with a primary focus on mouse and rodent models of disease.

The PPC seeks to build upon and expand the expert services previously provided by the Center for Integrative Genomics. In particularly, we are excited for our recent development of services providing micosurgical models of cardiovascular disease and state of the art assessment of cardiac function using miniaturized pressure-volume catheters.

While the focus of the PPC is primarily on cardiovascular phenotyping, many of the services, which are in close partnership with the U of M Cardiovascular Center Research Core, have broad applicability to numerous types of research programs including:

Cancer (e.g. ultrasound imaging of tumor volumes, cardiac complications of chemotherapeutics)

Circadian Rhythms (e.g. simultaneous telemetry monitoring of circadian blood pressure/EKG and wheel running activity)

Pharmacology and Experimental Therapeutics (e.g. osmotic pump implantation, vascular delivery)

Aging (e.g. decline in exercise capacity, aging related cardiac dysfunction)

Neuroscience (e.g neuromuscular testing, rotorod for learning)

If you have a research grant that would benefit from having direct access to PPC phenotyping services (such as a multi-PI, PPG or Center Grant), please feel free to contact the PPC Director, Daniel Michele. We would be happy to work with you on development of the research core portion of your proposal.

Acknowledgements

Kanthi, Y., Hyman, M.C., Liao, H., Baek, A.E., Visovatti, S.H., Sutton, N.R., Goonewardena, S.N., Neral, M.K., Jo, H., & Pinsky, D.J. (2015). Flow-dependent expression of ectonucleotide tri(di) phosphohydrolase-1 and suppression of atherosclerosis. J Clin Invest.

Zolov, S.N., Bridges, D., Yanling, Z., Lee, W., Riehle, E., Verma, R., Lenk, G.M., Converso-Baran, K., Weirde, T., Albin, R.L., Saltiel, A. R., Meisler, M.H., Russell, M.W., & Weisman, L.S. (2012). In vivo, Pikfyve generates PI(3.5)P₂, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci USA 109(43):17472-17477.