Journal Club

Steffanie Strathdee, PhD

Associate Dean of Global Health Sciences; Harold Simon Professor, UCSD Department of Medicine; Co-Director, Center for Innovative Phage Applications and Therapeutics; Author of The Perfect Predator

Talk: “The Perfect Predator: The Story Behind the First Dedicated Phage Therapy Program in North America”

Suggested Readings

• Comparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy

• Treat phage like living antibiotics

• Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection

Samuel Brown, PhD

Professor, Georgia Tech Biological Sciences

The Center for Microbial Dynamics and Infection (CMDI)

Talk: Can we make phage therapy both effective and evolutionarily robust?

Suggested Readings

• Building reusable phage and antibiotic treatments via exploitation of bacteria-phage coevolutionary dynamics

• Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation

Gina Suh, MD

Assistant Professor of Medicine, Mayo Clinic

Talk: "Going Viral: Phage Therapy Experience at Mayo Clinic"

Suggested Readings

• Phage Therapy for Limb-threatening Prosthetic Knee Klebsiella pneumoniae Infection: Case Report and In Vitro Characterization of Anti-biofilm Activity

• The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies

Vivek Mutalik, PhD

Staff Scientist, Environmental Genomics and Systems Biology: Comparative and Functional Genomics; Biological Systems and Engineering: Organismal Systems & Bioresilience, Biodesign at Lawrence Berkeley National Laboratory

Talk: "Pathogen mitigation through a target specific bacteriophage characterization and engineering platform"

Suggested Readings

• High-throughput mapping of the phage resistance landscape in E. coli

• The genetic basis of phage susceptibility, cross-resistance and host-range in Salmonella