Publications

Dedert, C., Mishra, V., Aggarwal, G., Nguyen, A.D., Xu, F. (2022) Progranulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress. Front. Cell. Neurosci. Sec.Cellular Neuropathology. doi: 10.3389/fncel.2022.874258

Pemberton, K.,  Rosato, M., Dedert, C., DeLeon, C., Arnatt, C., Xu, F. (2022) Differential Effects of the G Protein-Coupled Estrogen Receptor (GPER) on Rat Embryonic (E18) Hippocampal and Cortical Neurons. eNeuro 4 July 2022,  ENEURO.0475-21.2022; DOI: https://doi.org/10.1523/ENEURO.0475-21.

DeLeon, C., Pemberton, K., Green, M., Kalajdzic, V., Rosato, M., Xu, F., Arnatt, C. (2022) Novel GPER Agonist, CITFA, Increases Neurite Growth in Rat Embryonic (E18) Hippocampal Neurons. ACS Chem Neurosci. 13(8):1119-1128. doi: 10.1021/acschemneuro.1c00811.PubMed PMID: 353535102021

Rosato, M., Hoelscher, B.A., Lin, Z.,  Agwu, C.,  Xu, F. (2021) Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages.  BMC Genomics 22, 637. https://doi.org/10.1186/s12864-021-07946-y

Banerjee, S., Ghoshal, S., Girardet, C., DeMars, K.M., Yang, C., Niehoff, M.L., Nguyen, A.D., Jayanth, P. *, Hoelscher, B.A. **, Xu, F., Banks, W.A., Hansen, K.M., Zhang, J., Candelario-Jalil, E., Farr, S.A., Butler, A.A. (2021) Adropin expression correlates with aging-related neurophathology in the human brain and improves neuroinflammation and cognitive function in aging mice. npj Aging and Mechanisms of Disease. https://www.nature.com/articles/s41514-021-00076-5

Selvamani, V., Ezekiel, U.R., Xu, F. Subramanian,T.,  Hoelscher, B., San, K.,  Ganapathy, A., Geerling, E., Pemberton, K.,  Tycksen, E.D.,  Pinto, A.K.,  Brien, J.D.. Beck, D.,  Chung, W.K., Gurnett, C.A.,  Chinnadurai, G. (2020) Human iPSC-derived neuronal cells from CTBP1-mutated patients reveal altered expression of neurodevelopmental gene networks. Frontiers in Neuroscience.  https://doi.org/10.3389/fnins.2020.562292

Mersman BA, Zaidi, W., Syed, N.I., Xu F. (2020) Taurine promotes neurite outgrowth and synapse development of both vertebrate and invertebrate central neurons.   Frontiers in Synaptic Neuroscience  https://doi.org/10.3389/fnsyn.2020.00029

Mersman BA, Jolly SN, Lin Z, Xu F. (2020) Gap Junction Coding Innexin in Lymnaea stagnalis: Sequence Analysis and Characterization in Tissues and the Central Nervous System  Frontiers in Synaptic Neuroscience https://doi.org/10.3389/fnsyn.2020.00001

Morley JE, Farr SA, Nguyen AD, Xu F. (2019) Editorial: What is the Physiological Function of Amyloid-Beta Protein?. J Nutr Health Aging. 23(3):225-226. doi: 10.1007/s12603-019-1162-5. PubMed PMID: 30820508.

Pemberton, K., Mersman, B., and Xu, F. (2018) Using Image J to assess neurite outgrowth in mammalian cell cultures: research data quantification exercises in undergraduate neuroscience lab. The Journal of Undergraduate Neuroscience Education (JUNE). 16(2): A186-194. http://www.funjournal.org/wp-content/uploads/2018/06/june-16-186.pdf?x9129

Imaninezhad, M., Pemberton, K. Xu, F., Kalinowski, K., Bera, R., Zustiak, S.P. (2018) Directed and enhanced neurite outgrowth following exogenous electrical stimulation on carbon nanotube-hydrogel composites. Journal of Neural Engineering. 15(5):056034. doi: 10.1088/1741-2552/aad65b. https://www.ncbi.nlm.nih.gov/pubmed/30051883

Maselli, V., Xu, F., Syed, N.I., and Di Cosmo, A. (2018) A novel approach to primary cell culture for Octopus vulgaris neurons. Frontiers in Physiology 9:220. doi: 10.3389/fphys.2018.00220. https://www.frontiersin.org/articles/10.3389/fphys.2018.00220/full

Getz, A.M., Xu, F., Visser, F., Persson, R., Syed, N.I. (2017) Tumor suppressor menin is required for subunit-specific nAChR α5 transcription and nAChR-dependent presynaptic facilitation in cultured mouse hippocampal neurons. Scientific Reports, 2017 May 11; 7(1): 1768. doi:10.1038/s41598-017-01825. https://www.ncbi.nlm.nih.gov/pubmed/28496137

Xu, F., Armstrong, R., Urrego, D., Qazzaz, M., Pehar, M., Armstrong, J.N., Shutt, T., Syed, N.I. (2016) The mitochondrial division inhibitor Mdivi-1 rescues mammalian neurons from anesthetic-induced cytotoxicity. Molecular Brain, 9(1): 35. https://www.ncbi.nlm.nih.gov/pubmed/27009068

Armstrong, R., Xu, F., Rasic, N., Syed, N.I. (2016) General anesthetics and cytotoxicity: possible implications for brain health. Drug and Chemical Toxicology, 2:1-9.http://www.tandfonline.com/doi/abs/10.1080/01480545.2016.1188306

Getz, A.M., Visser, F., Bell, E.M., Xu, F., Flynn, N.M., Zaidi, W., Syed, N.I. (2016) Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors uring synaptogenesis between Lymnaea neurons. Scientific Reports, 19;6:31779. doi: 10.1038/srep31779.https://www.nature.com/articles/srep31779

Janes, T.A., Xu, F., Syed. N.I (2015) Graded hypoxia acts through a network of distributed peripheral oxygen chemoreceptors to produce changes in respiratory behavior and plasticity.  European Journal of Neuroscience, 42 (2): 1858-71. Pubmed

Ghazavi, A., Westwich, D., Xu, F., Wijdenes, P., Syed, N.I., Dalton, C. (2015) A circular, planar electrode serves as a better substrate for neuronal stimulation than sinusoidal and spiral electrodes. Journal of Neuroscience Methods, 248: 51-58.https://www.ncbi.nlm.nih.gov/pubmed/25845480

Singh, B., Krishnan, A., Micu, I., Koshy, K., Singh, V., Martinez, J.A., Koshy, D., Xu, F., Chandrasekhar, A., Dalton, C., Syed, N., Stys P.K., Zochodne, D. W.  (2015) Peripheral neuron plasticity is enhanced by brief electrical stimulation and overrides attenuated regrowth in experimental diabetes. Neurobiology of Disease, 83: 134-151. Pubmed

Xu, F., Luk, C., Wiermsa-Meems, R., Baehre, K., Herman, C., Zaidi, W., Wong, N., and Syed, N.I.  (2014) Neuronal somata and extrasomal compartments play distinct roles during synapse formation between Lymnaea neurons. Journal of Neuroscience, 34(34): 11304-15. Pubmed

Chen, P., Jiang, H., Wen, B., Ren, S., Chen, Y., Ji, W., Hu, B., Zhang, J., Xu, F., Zhu, Z. (2014) Gastrodin suppresses amyloid β–induced increase of spontaneous discharges in entorhinal cortex of rats. Neural Plasticity (2014:320937. doi: 10.1155, Epub) Pubmed

Chen, S., Chen, P., Jiang, H., Mi, Z., Xu, F. *, Hu, B., Zhang, J., Zhu., Z. (2014) Persistent sodium currents contribute to Aβ1-42-induced hyperexcitation of hippocampal CA1 pyramidal neurons. Neuroscience Letters, 580: 62-67 (Co-corresponding author). Pubmed

Zhu, Z., Xu, F., Ji, W., Ren, S., Chen, F., Chen, P., Jiang, H., Mi, Z., Hu, B., Zhang, J., Xiong, Y. (2014) Synaptic mechanisms underlying thalamic activation-induced plasticity in the rat auditory cortex. Journal of Neurophysiology, 111(9): 1746-58. Pubmed

Ren, S., Shao, H., Ji, W., Xu, F., Chen, P., Jiang, H., Mi, Z., Wen, Bo., Zhu, G., Zhu, Z. (2014) Riluzole prevents soluble Aβ1-42 oligomers-induced perturbation of spontaneous discharges in the hippocampal CA1 region of rats. Amyloid, 4:1-9. Pubmed

Zhu, Z., Xu, F., Wu, J., Ren, S., Zhang, Y., Hu, B., Zhang, J., Han, L., Xiong, Y. (2013) Frequency-specific plasticity of the auditory cortex elicited by thalamic stimulation in the rat. Neuroscience Letters, 555: 30-35. Pubmed

Xu, F., Piett, C., Farkas, S., Qazzaz, M.., and Syed, N.I. (2013) Silver nanoparticles (AgNPs) cause degeneration of cytoskeleton and disrupt synaptic machinery of cultured cortical neurons. Molecular Brain, 6(1): 29. (Corresponding author) Pubmed

Xu, F., Farkas, S., Kortbeek, S., Zhang, F.X., Chen, L., Zamponi, G.W., and Syed, N.I. (2012) Mercury-induced toxicity of rat cortical neurons is mediated through NMDA receptors. Molecular Brain, 5(1): 30. (Corresponding author) Pubmed

Getz, A, Xu, F. and Syed N.I. (2012) Antidepressant Pharmacotherapy – Do the Benefits Outweigh the Risks? InTech book chapter – Mental Illness (ISBN: 978-953-307-779-6)

Getz, A., Xu, F., Zaidi, W., Syed, N.I.  (2011) The antidepressant Fluoxetine but not Citalopram suppresses synapse formation and synaptic transmission between Lymnaea neurons by perturbing pre- and postsynaptic machinery. European Journal of Neuroscience, 34(2): 221-234. Pubmed

Xu, F., Proft J., Gibbs, S., Winkfein, B., Johnson, J.N., Syed, N.I., and Braun J.E.A. (2010) Quercetin causes cysteine string protein dimerization and impairs synaptic transmission.  PLoS ONE, 5 (6): e11045. Pubmed

Xu, F., Luk, C., Richard, M.P, Zaidi, W., Svetlana, F., Getz, A., Lee, A., van Minnen, J., and Syed, N.I. (2010) Antidepressant Fluoxetine suppresses neuronal growth and perturbs synapse  formation between cholinergic neurons. European Journal of Neuroscience, 31(6): 994-1005.  Pubmed

Xu, F., Hennessy, D.A., Lee, T., and Syed, N.I. (2009) Trophic factor-induced intracellular calcium oscillations are required for the expression of postsynaptic acetylcholine receptors during synapse formation between Lymnaea neurons. Journal of Neuroscience 29 (7): 2167-2176. Pubmed

Xu, F., Tse, F.W., and Tse, A.. (2008) Stimulatory actions of pituitary adenylate cyclase-activating polypeptide (PACAP) in rat carotid glomus cells. Advanced Experimental Medical Biology 605:69-74. Pubmed

Xu, F., Tse, F.W. and Tse, A. (2007) Pituitary adenylate cyclase-activating polypeptide (PACAP)   stimulates the oxygen sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK-like K+ current. Journal of Neurochemistry 101(5):1284-93. Pubmed

Xu, F., Xu, J., Tse, F.W. and Tse, A. (2006) Adenosine stimulates depolarization and rise in cytoplasmic Ca2+ concentration in type I cells of rat carotid bodies. American Journal of Physiology– Cell Physiology 290(6):C1592-8. Pubmed

Xu, J., Xu, F., Tse, F.W. and Tse, A. (2005) ATP inhibits the hypoxia response in type I cells of rat carotid bodies. Journal of Neurochemistry 92:1419-1430. Pubmed