Welcome to the Janowiak lab web pages!
The Janowiak lab uses biochemistry, microbiology, and molecular genetics to explore the relationship between microbes and their environment. We have two main focuses:
1) Gram-positive pathogenic bacteria and their response to oxidative stresses produced by the mammalian host
Our bacteria of interest include Group B Streptococcus (Streptococcus agalactiae), Enterococcus faecalis, and Streptococcus pyogenes. Our favorite oxidative stress response is glutathione, and we specifically study its synthesis, import, export, and metabolism in bacteria. To study the regulation of and the molecular mechanisms involved with glutathione metabolism, we are employing a combination of transcriptomics, metabolomics, and good old fashion biochemistry.
2) The contribution of glutathione and other antioxidants to the survival and maintenance of bacteria residing in the mouse vaginal microbiome
We are examining the effect of glutathione metabolism on the biodiversity of the vaginal microbiota. Group B Streptococcus is often found in the healthy vaginal microbiome, but can become an opportunistic pathogen and cause significant disease. Therefore, we are interested in the role antioxidants, namely glutathione, play in maintaining a healthy vaginal microbiome.
Collaborations with other SLU faculty
We are lending our biochemical expertise in oxidative stress and antioxidants to help out Dr. Jon Fisher's lab (SLU biology) in studying asorbic acid and dehydroasorbic acid. (Fisher Lab)
With Dr. Laurie Shornick (SLU biology) and Dr. Scott Sell (SLU biomedical engineering), we are using our knowledge of glutathione to study the redox state of diabetic wounds in the presence and absence of Manuka honey wound dressings. In addition, we are using our microbiome skills to compare the micrbobiota between Manuka honey-treated diabetic wounds and non-treated wounds. (Shornick Lab) (Sell Lab)
With Dr. Joyce Koenig (SLU Pediatrics and Molecular Biology and Immunology), we are using our shared interests in Group B Streptococcus and neutrophil biology to ask interesting questions at the interface between the pathogen and its host. (Koenig Lab)
For more information about our research, please feel free to contact me at bjanowia[at]slu.edu, or check out my ResearchGate, Academia.edu or LinkedIn pages.
Thanks for visiting!
Last updated: July 1, 2015
The Crew of Summer 2015
The Janowiak Lab in the Fall of 2014
The Crew of Summer 2014
The Crew of Fall 2013
The Crew of Summer 2013
A subset of "Team Strep" after presenting our work at the Biology Department Symposium