Engineering next-generation CAR-X immunotherapies
through the convergence of NK/T cell biology, RNA biology, and gene therapy.
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[keywords: NK/T cell, RNA biology, Gene therapy, CAR-X therapy]
Immune cell biology (Basics)
• NK/T cell development/activation
• Mathematical modeling
• iPSC-derived Mp and NK differentiation
RNA Biology (Basics)
• mRNA metabolism
• Noncoding RNAs: miRNA, lncRNA
• RNA methylation (m6A)
• mir-150/FTO KO animal model
Gene-cell therapy (Applications)
• Gene design/RNA design
• CAR-X engineering
• Prime editing (CRISPR)/Gene delivery (LNP)
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