Publications

Partin AC, Zhang K, Jeong BC, Herrell E, Li S, Chiu W, & Nam Y (2020) Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. Molecular Cell. doi: 10.1016/j.molcel.2020.02.016. PMID: 32220646.

Ngo TD, Partin AC, & Nam Y (2019) RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis. Cell Reports 29(12):4024-4035 e4025. PMC6953907.

Doxtader KA & Nam Y (2019) Manipulation by Methylation: Garnishing mRNAs with m(6)Am. Molecular Cell 75(3):417-418. PMC6860360.

Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, & Sliz P (2018) Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Reports 23(10):3091-3101. PMC6511231.

Doxtader KA, Wang P, Scarborough AM, Seo D, Conrad NK, & Nam Y (2018) Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor. Molecular Cell 71(6):1001-1011 e1004. PMC6367934.

Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, & Sliz P (2017) LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation. Cell Reports 18(11):2664-2675.

Partin AC, Ngo TD, Herrell E, Jeong BC, Hon G, & Nam Y (2017) Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs. Nature Communications 8(1):1737. PMC5700927.

Wang P, Doxtader KA, & Nam Y (2016) Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Molecular Cell 63(2):306-317. PMC4958592.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferre-D'Amare AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, & Sliz P (2016) Data publication with the structural biology data grid supports live analysis. Nature Communications 7:10882. PMC4786681.

Liu H, Liang C, Kollipara RK, Matsui M, Ke X, Jeong BC, Wang Z, Yoo KS, Yadav GP, Kinch LN, Grishin NV, Nam Y, Corey DR, Kittler R, & Liu Q (2016) HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing. Molecular Cell 63(3):420-432. PMC4975613.

O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schroder GF, Brunger AT, & Sliz P (2012) A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr 68(Pt 3):261-267. PMC3282622.

Choi S, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, & Blacklow SC (2012) Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes. Structure 20(2):340-349.

Nam Y, Chen C, Gregory RI, Chou JJ, & Sliz P (2011) Molecular basis for interaction of let-7 microRNAs with Lin28. Cell 147(5):1080-1091. PMC3277843.

Lazarus MB, Nam Y, Jiang J, Sliz P, & Walker S (2011) Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature 469(7331):564-567. PMC3064491.

Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, & Pear WS (2011) Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. PLOS ONE 6(10):e25645. PMC3192765.

Zimmer J, Nam Y, & Rapoport TA (2008) Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature 455(7215):936-943. PMC7164768.

Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, & Rapoport TA (2008) A role for the two-helix finger of the SecA ATPase in protein translocation. Nature 455(7215):984-987. PMC4354775.

Nam Y, Sliz P, Pear WS, Aster JC, & Blacklow SC (2007) Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A 104(7):2103-2108. PMC1892977.

Nam Y, Sliz P, Song L, Aster JC, & Blacklow SC (2006) Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124(5):973-983.

Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, & Aster JC (2006) Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1. Molecular and Cellular Biology 26(16):6261-6271.

Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, & Aster JC (2003) Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Molecular and Cellular Biology 23(2):655-664. PMC151540.

Nam Y, Weng AP, Aster JC, & Blacklow SC (2003) Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. Journal of Biological Chemistry 278(23):21232-21239. PMID: 12644465.

Nam Y, Aster JC, & Blacklow SC (2002) Notch signaling as a therapeutic target. Current Opinion in Chemical Biology 6(4):501-509. PMID: 12133727.