How structure and chemistry govern RNA-protein interactions 

The Nam lab asks how the shape of an RNA regulates its function. We study the biochemical and structural mechanisms in RNA-mediated gene regulation pathways important for normal and disease states. RNAs often exert their functionality through unique interactions with proteins. We are studying how noncoding RNAs are processed and regulated by RNA-binding proteins and chemical modifications. Using biochemistry and structural biology, we dissect the molecular mechanisms underlying specific, important RNA-protein interactions that contribute to diseases such as cancer. We ground our studies to biology by using cell and animal models and the validated mechanistic insights help us find novel therapeutic avenues.