How structure and chemistry govern RNA-protein interactions

The Nam lab asks how the shape of an RNA regulates its function. We study the biochemical and structural mechanisms in RNA-mediated gene regulation pathways important for normal and disease states. RNAs often exert their functionality through unique interactions with proteins. We are studying how noncoding RNAs are processed and regulated by RNA-binding proteins and chemical modifications. Using biochemistry and structural biology, we investigate the molecular mechanisms underlying specific, important RNA-protein interactions. We also apply our understanding of the molecular mechanisms to find new avenues for drug discovery.